Reviewed, UniProtKB/Swiss-Prot Q54P13 (ABCC8_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter C family member 8
Alternative name(s):
    ABC transporter ABCC.8

Gene names

Name:	abcC8
ORF Names:	DDB_G0284867

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1593 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Coiled coil Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1593	1593	ABC transporter C family member 8		PRO_0000363853
Regions
	Transmembrane	27 – 47	21	Potential
	Transmembrane	75 – 95	21	Potential
	Transmembrane	100 – 120	21	Potential
	Transmembrane	135 – 155	21	Potential
	Transmembrane	169 – 189	21	Potential
	Transmembrane	280 – 300	21	Potential
	Transmembrane	318 – 338	21	Potential
	Transmembrane	392 – 412	21	Potential
	Transmembrane	419 – 439	21	Potential
	Transmembrane	505 – 525	21	Potential
	Transmembrane	1005 – 1025	21	Potential
	Transmembrane	1064 – 1084	21	Potential
	Transmembrane	1157 – 1177	21	Potential
	Transmembrane	1251 – 1271	21	Potential
	Transmembrane	1280 – 1300	21	Potential
	Domain	280 – 561	282	ABC transmembrane type-1 1
	Domain	594 – 818	225	ABC transporter 1
	Domain	1010 – 1308	299	ABC transmembrane type-1 2
	Domain	1344 – 1578	235	ABC transporter 2
	Nucleotide binding	627 – 634	8	ATP Potential
	Nucleotide binding	1378 – 1385	8	ATP Potential
	Coiled coil	844 – 875	32	Potential
	Compositional bias	821 – 829	9	Poly-Gln
Experimental info
	Sequence conflict	61	1	S → F in AAL85711. Ref.1
	Sequence conflict	1325	1	E → K in AAL85711. Ref.1
	Sequence conflict	1587	1	D → N in AAL85711. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q54P13-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: C1BC5D9F4A480A35	FASTA	1,593	178,339
	10 20 30 40 50 60 MGFCGDEPFT VWHNDSGDFS KCFEDSVVMT LPAIYLLIFG MKRLYYLENK KPDLFTLKQL 70 80 90 100 110 120 SQDFQTWRKT LQLEVIVSIL LVAWKILFFI VIVSIYNKPF EILYSVVTVV QWTVSLGLVY 130 140 150 160 170 180 LEMKKGQSRS WEIRLYWVFA FFVATVKLRT LTLAIAGKSI YNVGFLEYFS YFVGYCLILI 190 200 210 220 230 240 LSITSVLFFD NLESYQNLEE NEISKEVNAN LFSRLTFWWI NSVLVKGHKK ALEISDVPTL 250 260 270 280 290 300 GEIDQSILLS EKFEKAWEEQ LKKPNPSLPW ALAKAFGPHF YIAALFKIIQ DLLIFVGPTL 310 320 330 340 350 360 LKRVLGFVES RDGSQDTYDG LIYALLYFLA PVVQSLLLHQ YFHRCYRVGM WLRSAVVTAV 370 380 390 400 410 420 YKKALKTSLR EGTTIGEIVN LMSVDAQKFM DLCPYLHMIW SAPLQLAISL VLLYRILNAS 430 440 450 460 470 480 VFAGLGIMLV MIPINLAISN LAKKRQTISM KLKDRRTKAV NEVLNGIKVI KLYSWEQSFM 490 500 510 520 530 540 DHVNEIRNKE LDVMKAIKYI QGFSLLLWSM SPVFVSVSTF TVYILTGQVL SATQAFPALS 550 560 570 580 590 600 LFNVMQFPIN MLPSVVSSII EASVSVARLQ KFLLKKDLDP NVVEHHINEP GIAVKIDNAT 610 620 630 640 650 660 LEWEPNKPIL HDINLTIKKG ELVAIVGQVG SGKSSIVSSL VGDLDKTKGT VAVNGSVALV 670 680 690 700 710 720 SQQAWIQNAT LKNNILFAKE LNQDKYQSVV QACCLEPDIK ILPGGDQTEI GEKGINLSGG 730 740 750 760 770 780 QKQRVSIARA VYNNADIYIF DDPLSAVDAH VGKAIFKNVL SNQDGILCNK TRILVTHAVH 790 800 810 820 830 840 YLPYVDRIIL MKDGRIVEEG DFNTLIEAGS HFTELMSHDE QQQQLQQQQA PDKSSDSNEQ 850 860 870 880 890 900 IGGGDNKESE NNEEQNEEEE GENENLLEKV LRKSRSRSPS PSSNRNIDGD DIASGSILQT 910 920 930 940 950 960 TRTPEEDEQD ERELMEDIDI DGGENIQTPL QKGEKSSVLK QPLRLLKKLP TSINKKLNNS 970 980 990 1000 1010 1020 GSGVSLKPIT TVNAKPQDKN KIISVETKQE GKVSFKIYLS YFKAIGVLLA TCIIGFYVLT 1030 1040 1050 1060 1070 1080 QLLSILANWW ISIWTNSYGG NGNGSGSGSI SLSSSSTVED NEKAKYYLSI YVAFSCGTIA 1090 1100 1110 1120 1130 1140 ATFLRSFSMV FGSIKGSKLF HEKMFKAVIL SPMSFFDTTP IGRILNRFSK DQLTIDESIA 1150 1160 1170 1180 1190 1200 RTLGMFLNTF CQVVGSIIVI AWVSPFIILA MVPVGALFYF IQKYYLNSSR ELTRLEGVSR 1210 1220 1230 1240 1250 1260 SPIYAHFSET LAGVTTIRAF KDVARFVTEN ERLLDENQKC YYINISSNRW LAIRLEFLGA 1270 1280 1290 1300 1310 1320 CLVSCAVLYT VLARSRIEAG TAGLVITYAL AITGNMNWMV RMSCDLENSV VSIERIQEYC 1330 1340 1350 1360 1370 1380 LLPSEAPLFN DKSVPMSWPS HGKIVFKNLW LTYREGLDPV LRGINCTIEP KTKVGIVGRT 1390 1400 1410 1420 1430 1440 GAGKSSLTQA LFRLVEPLRG TIEIDGIDIT ELGLNPLRSR MAIIPQDPVL FAGSVRYNLD 1450 1460 1470 1480 1490 1500 PFDQYDDHEI WEAIENAHLL KAIKDLDGGL DAMVQDGGDN FSVGQRQLLV IGRALLKKAN 1510 1520 1530 1540 1550 1560 IIVLDEASSS IDIASDALIQ ETIRTKFADC TVLTIAHRLG TIADSDKIMV LDKGELIEYD 1570 1580 1590 SPSELLKNQD SIYYSLVKAS ESKQNIDNDD ESN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF474340 Genomic DNA. Translation: AAL85711.1. AAFI02000073 Genomic DNA. Translation: EAL64897.1.
RefSeq	XP_639904.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ModBase	Search...
Genome annotation databases
GeneID	3391105.
GenomeReviews	Gene locus abcC8 in contig CM000153_GR.
KEGG	ddi:DDB_0191225.
Organism-specific databases
dictyBase	DDB_G0284867. abcC8.
Phylogenomic databases
HOGENOM	HBG758042.
InParanoid	Q54P13.
OMA	DERELME.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCC8_DICDI

Accession

Primary (citable) accession number: Q54P13
Secondary accession number(s): Q8T6H1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	December 15, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)