Reviewed, UniProtKB/Swiss-Prot Q54P00 (ABKD_DICDI)

Names and origin

Protein names

Recommended name:
    Probable serine/threonine-protein kinase abkD
    EC=2.7.11.-

Gene names

Name:	abkD
Synonyms:	adckB2
ORF Names:	DDB_G0284897

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Coiled coil Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 695	695	Probable serine/threonine-protein kinase abkD		PRO_0000367579
Regions
	Transmembrane	177 – 193	17	Potential
	Domain	317 – 695	379	Protein kinase
	Nucleotide binding	323 – 331	9	ATP By similarity
	Coiled coil	118 – 150	33	Potential
	Compositional bias	52 – 63	12	Poly-Asn
	Compositional bias	120 – 139	20	Poly-Gln
Sites
	Active site	477	1	Proton acceptor By similarity
	Binding site	345	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54P00-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: A3A6B0E561A137F8	FASTA	695	80,336
	10 20 30 40 50 60 MKILKFSLLS KLKHKDFIVT SFRNNIINSI KNNNTNNNGL LKFSNNKYNF LNNNNNNNNN 70 80 90 100 110 120 NVNKINNVYY INNNFKNVME NKIKPSSIQF FSSLSNKYNL NSFTTTKPQP CQAKPPSSKQ 130 140 150 160 170 180 QQQQQQQQQQ QQQQQQQQQS KKKTSKDRLR DILKKTVITP QEFLNVLQRF AKNYKKTIAS 190 200 210 220 230 240 ILAAIALIIY SYETPDSYFG SMMNVIVRFY RAMKCATKIM INYKILSYTP EKSSEYLEKS 250 260 270 280 290 300 KICHQESADL ILDLCLTNGG LYIKAGQYIA SLNHILPIQY TKTLSVLQDQ APWRDFYEVE 310 320 330 340 350 360 SVFLKDLGNA PNHYFSDFDR LPIAAASLAQ VHRAITKEGE EVAVKVQYVD LQRNFDGDIF 370 380 390 400 410 420 THNVLLTLVN MAFPDFEFNW MAEEMKNVLI KELDFSQEAD NAERAAQDLS SNNNAYIPKV 430 440 450 460 470 480 FRPYSSKRIL TTEFIHGCKI NNVQAIRSMG LSEKTVSQRF MEIMCEQIFI HAFVHVDPHA 490 500 510 520 530 540 GNVLVRQHPN HPNQPQIVLL DHGLYREYDE EFRLNFCNLY KNLVLCNNKK VEKYSKALGV 550 560 570 580 590 600 QNWKLFSTMI LMRNFEGSSV GLSNSISSEE LEKLLSGAIE RLKDINLLMK AMPRHLLLIL 610 620 630 640 650 660 RNNNLLRSIN MELGSPVNRF SIMARYAAKG LNSNSSKNSG IIRLVKSVEE KVSLEVMLKG 670 680 690 YELYYYFVNR ILSILIRLHI INPEKLIKDQ MKKLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The dictyostelium kinome -- analysis of the protein kinases from a simple model organism." Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L. PLoS Genet. 2:E38-E38(2006) [PubMed: 16596165] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[3]	"Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains." Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R., Ivens A., Martinez J.L., Escalante R. BMC Microbiol. 8:109-109(2008) [PubMed: 18590548] [Abstract] Cited for: INDUCTION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000073 Genomic DNA. Translation: EAL64912.1.
RefSeq	XP_639917.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3390995.
GenomeReviews	Gene locus abkD in contig CM000153_GR.
KEGG	ddi:DDB_0216431.
Organism-specific databases
dictyBase	DDB_G0284897. abkD.
Family and domain databases
InterPro	IPR004147. ABC_1. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABKD_DICDI

Accession

Primary (citable) accession number: Q54P00

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 24, 2005
Last modified:	November 24, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)