Q54NZ7 (ALRB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldose reductase B
Short name=ARB
EC=1.1.1.21

Alternative name(s):
Aldehyde reductase B

Gene names

Name:	alrB
ORF Names:	DDB_G0285053

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies By similarity.
Catalytic activity	Alditol + NAD(P)+ = aldose + NAD(P)H.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	alditol:NADP+ 1-oxidoreductase activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Aldose reductase B		PRO_0000327646
Regions
	Nucleotide binding	13 – 23	11	NADP Potential
	Nucleotide binding	219 – 273	55	NADP By similarity
Sites
	Active site	54	1	Proton donor By similarity
	Binding site	116	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54NZ7 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: F60EBB244639962D	FASTA	311	35,060
	10 20 30 40 50 60 MSQPQNTFKL NDDIHHIPMI GLGTYNGAKV GEVGDAVKVA LKSGYRHIDG AAIYMNEKEI 70 80 90 100 110 120 GHALKEVFAE GEIKREDIFY VSKLWNSCHH ASLVRKHCEK TLEDLGLEYL DLYLIHWPIA 130 140 150 160 170 180 FENADPSGTT TQPLRDSDGE PVLAAVSIRE TWQEMEKLVE YGLVKSIGVS NFNVQNLVDL 190 200 210 220 230 240 LTYAKIKPAI NQVEVHPYLS QPNLKYFCDR YGIVLTAYSP LGQGKCDLLS NETLKSIADK 250 260 270 280 290 300 HNKTVANVIF KWLNQRGIVT IPKSSNPARI IENFNIFDFQ LSNEDMDKIN SLNSNLRTCT 310 PANFCKIPLF D

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000073 Genomic DNA. Translation: EAL64990.2.
RefSeq	XP_639920.2. XM_634828.2.
3D structure databases
HSSP	HSSP built from PDB template 2ALR based on UniProtKB P14550.
ProteinModelPortal	Q54NZ7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231282; DDB0231282; DDB_G0285053.
GeneID	8624832.
GenomeReviews	Gene locus alrB in contig CM000153_GR.
KEGG	ddi:DDB_G0285053.
Organism-specific databases
dictyBase	DDB_G0285053. alrB.
Phylogenomic databases
eggNOG	KOG1577.
GeneTree	EPrGT00050000003304.
HOGENOM	HBG605727.
OMA	KEIGHAL.
PhylomeDB	Q54NZ7.
ProtClustDB	CLSZ2429209.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALRB_DICDI

Accession

Primary (citable) accession number: Q54NZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	September 21, 2011
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)