Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aldose reductase B

Gene

alrB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.By similarity

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54Proton donorBy similarity1
Binding sitei116SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 23NADPSequence analysisAdd BLAST11
Nucleotide bindingi219 – 273NADPBy similarityAdd BLAST55

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-DDI-156590 Glutathione conjugation
R-DDI-193144 Estrogen biosynthesis
R-DDI-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-DDI-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-DDI-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-DDI-196108 Pregnenolone biosynthesis
R-DDI-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-DDI-5365859 RA biosynthesis pathway
R-DDI-5652227 Fructose biosynthesis
R-DDI-5661270 Catabolism of glucuronate to xylulose-5-phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase B (EC:1.1.1.21)
Short name:
ARB
Alternative name(s):
Aldehyde reductase B
Gene namesi
Name:alrB
ORF Names:DDB_G0285053
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285053 alrB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276461 – 311Aldose reductase BAdd BLAST311

Proteomic databases

PaxDbiQ54NZ7
PRIDEiQ54NZ7

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231282

Structurei

3D structure databases

ProteinModelPortaliQ54NZ7
SMRiQ54NZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
InParanoidiQ54NZ7
KOiK00011
OMAiFNNGEKM
PhylomeDBiQ54NZ7

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q54NZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPQNTFKL NDDIHHIPMI GLGTYNGAKV GEVGDAVKVA LKSGYRHIDG
60 70 80 90 100
AAIYMNEKEI GHALKEVFAE GEIKREDIFY VSKLWNSCHH ASLVRKHCEK
110 120 130 140 150
TLEDLGLEYL DLYLIHWPIA FENADPSGTT TQPLRDSDGE PVLAAVSIRE
160 170 180 190 200
TWQEMEKLVE YGLVKSIGVS NFNVQNLVDL LTYAKIKPAI NQVEVHPYLS
210 220 230 240 250
QPNLKYFCDR YGIVLTAYSP LGQGKCDLLS NETLKSIADK HNKTVANVIF
260 270 280 290 300
KWLNQRGIVT IPKSSNPARI IENFNIFDFQ LSNEDMDKIN SLNSNLRTCT
310
PANFCKIPLF D
Length:311
Mass (Da):35,060
Last modified:May 2, 2006 - v2
Checksum:iF60EBB244639962D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000073 Genomic DNA Translation: EAL64990.2
RefSeqiXP_639920.2, XM_634828.2

Genome annotation databases

EnsemblProtistsiEAL64990; EAL64990; DDB_G0285053
GeneIDi8624832
KEGGiddi:DDB_G0285053

Similar proteinsi

Entry informationi

Entry nameiALRB_DICDI
AccessioniPrimary (citable) accession number: Q54NZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health