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Protein

Aldose reductase B

Gene

alrB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.By similarity

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54Proton donorBy similarity1
Binding sitei116SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 23NADPSequence analysisAdd BLAST11
Nucleotide bindingi219 – 273NADPBy similarityAdd BLAST55

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-DDI-156590. Glutathione conjugation.
R-DDI-193144. Estrogen biosynthesis.
R-DDI-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-DDI-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-DDI-193807. Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
R-DDI-196108. Pregnenolone biosynthesis.
R-DDI-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-DDI-5365859. RA biosynthesis pathway.
R-DDI-5652227. Fructose biosynthesis.
R-DDI-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase B (EC:1.1.1.21)
Short name:
ARB
Alternative name(s):
Aldehyde reductase B
Gene namesi
Name:alrB
ORF Names:DDB_G0285053
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285053. alrB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276461 – 311Aldose reductase BAdd BLAST311

Proteomic databases

PaxDbiQ54NZ7.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231282.

Structurei

3D structure databases

ProteinModelPortaliQ54NZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
InParanoidiQ54NZ7.
KOiK00011.
PhylomeDBiQ54NZ7.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54NZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPQNTFKL NDDIHHIPMI GLGTYNGAKV GEVGDAVKVA LKSGYRHIDG
60 70 80 90 100
AAIYMNEKEI GHALKEVFAE GEIKREDIFY VSKLWNSCHH ASLVRKHCEK
110 120 130 140 150
TLEDLGLEYL DLYLIHWPIA FENADPSGTT TQPLRDSDGE PVLAAVSIRE
160 170 180 190 200
TWQEMEKLVE YGLVKSIGVS NFNVQNLVDL LTYAKIKPAI NQVEVHPYLS
210 220 230 240 250
QPNLKYFCDR YGIVLTAYSP LGQGKCDLLS NETLKSIADK HNKTVANVIF
260 270 280 290 300
KWLNQRGIVT IPKSSNPARI IENFNIFDFQ LSNEDMDKIN SLNSNLRTCT
310
PANFCKIPLF D
Length:311
Mass (Da):35,060
Last modified:May 2, 2006 - v2
Checksum:iF60EBB244639962D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64990.2.
RefSeqiXP_639920.2. XM_634828.2.

Genome annotation databases

EnsemblProtistsiEAL64990; EAL64990; DDB_G0285053.
GeneIDi8624832.
KEGGiddi:DDB_G0285053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64990.2.
RefSeqiXP_639920.2. XM_634828.2.

3D structure databases

ProteinModelPortaliQ54NZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231282.

Proteomic databases

PaxDbiQ54NZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL64990; EAL64990; DDB_G0285053.
GeneIDi8624832.
KEGGiddi:DDB_G0285053.

Organism-specific databases

dictyBaseiDDB_G0285053. alrB.

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
InParanoidiQ54NZ7.
KOiK00011.
PhylomeDBiQ54NZ7.

Enzyme and pathway databases

ReactomeiR-DDI-156590. Glutathione conjugation.
R-DDI-193144. Estrogen biosynthesis.
R-DDI-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-DDI-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-DDI-193807. Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
R-DDI-196108. Pregnenolone biosynthesis.
R-DDI-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
R-DDI-5365859. RA biosynthesis pathway.
R-DDI-5652227. Fructose biosynthesis.
R-DDI-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Miscellaneous databases

PROiQ54NZ7.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALRB_DICDI
AccessioniPrimary (citable) accession number: Q54NZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.