Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q54NZ7 (ALRB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose reductase B

Short name=ARB
EC=1.1.1.21
Alternative name(s):
Aldehyde reductase B
Gene names
Name:alrB
ORF Names:DDB_G0285053
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies By similarity.

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionalditol:NADP+ 1-oxidoreductase activity

Inferred from sequence or structural similarity. Source: dictyBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Aldose reductase B
PRO_0000327646

Regions

Nucleotide binding13 – 2311NADP Potential
Nucleotide binding219 – 27355NADP By similarity

Sites

Active site541Proton donor By similarity
Binding site1161Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54NZ7 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: F60EBB244639962D

FASTA31135,060
        10         20         30         40         50         60 
MSQPQNTFKL NDDIHHIPMI GLGTYNGAKV GEVGDAVKVA LKSGYRHIDG AAIYMNEKEI 

        70         80         90        100        110        120 
GHALKEVFAE GEIKREDIFY VSKLWNSCHH ASLVRKHCEK TLEDLGLEYL DLYLIHWPIA 

       130        140        150        160        170        180 
FENADPSGTT TQPLRDSDGE PVLAAVSIRE TWQEMEKLVE YGLVKSIGVS NFNVQNLVDL 

       190        200        210        220        230        240 
LTYAKIKPAI NQVEVHPYLS QPNLKYFCDR YGIVLTAYSP LGQGKCDLLS NETLKSIADK 

       250        260        270        280        290        300 
HNKTVANVIF KWLNQRGIVT IPKSSNPARI IENFNIFDFQ LSNEDMDKIN SLNSNLRTCT 

       310 
PANFCKIPLF D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000073 Genomic DNA. Translation: EAL64990.2.

3D structure databases

ProteinModelPortalQ54NZ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231282.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231282; DDB0231282; DDB_G0285053.
KEGGddi:DDB_G0285053.

Organism-specific databases

dictyBaseDDB_G0285053. alrB.

Phylogenomic databases

eggNOGCOG0656.
OMANSCHHAS.
PhylomeDBQ54NZ7.
ProtClustDBCLSZ2429209.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALRB_DICDI
AccessionPrimary (citable) accession number: Q54NZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase