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Q54NW6

- OPLA_DICDI

UniProt

Q54NW6 - OPLA_DICDI

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Protein

5-oxoprolinase

Gene

oplah

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.By similarity

Catalytic activityi

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

GO - Molecular functioni

  1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_206208. Glutathione synthesis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Pyroglutamase
Gene namesi
Name:oplah
ORF Names:DDB_G0284953
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284953. oplah.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126512655-oxoprolinasePRO_0000328515Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0186276.

Family & Domainsi

Sequence similaritiesi

Belongs to the oxoprolinase family.Curated

Phylogenomic databases

eggNOGiCOG0146.
InParanoidiQ54NW6.
KOiK01469.
OMAiVEAYMGH.
PhylomeDBiQ54NW6.

Family and domain databases

InterProiIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamiPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54NW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIDKLKKSI KFNIDRGGTF TDIYAEFPYE PYYIVEKLLS VDPENYSDAP
60 70 80 90 100
REGIRRILER IQGKSISKEN VDTYAIKSIR MGTTVGTNAL LERKGEKVLL
110 120 130 140 150
VTSKGFRDLL QIGNQSRPKI FELNITKPEL IYNSVVELDE RVQIVTNDQV
160 170 180 190 200
LNDIKLESPN SLKKGTTGDY IKVLEIPNRD KIKSELLKYF VKGIKSIAVV
210 220 230 240 250
FIHSYTFHDH ELLVGEIAKE IGFEHISLSH QLMPMIKAVP RGLTSCVDAY
260 270 280 290 300
LTPLIELYIK NFTKGFDSNI GDVDISFMMS DGGLCPVDSF RGFRSILSGP
310 320 330 340 350
AGGVVGYSKT TSTVIESHKN NNGNNEIKQQ PIIGFDMGGT STDVSRYNGT
360 370 380 390 400
LDHVFETEIS GLTIQAPQLD IHTVAAGGGS RLFFKSGLFL VGPESVGAHP
410 420 430 440 450
GPVCYKKNGQ LAITDANLLL GRLLPEYFPP IFGPNQNEPL DLEATKKAFK
460 470 480 490 500
ELTDEINQFQ QNNNLPLMTE DQVAFGFIRV ANEAMCRPIR NITEAKGFDC
510 520 530 540 550
SQHVLACFGG AGGQHSCSIA QNLGMPKVFI HRFSGILSAY GLGLADLVID
560 570 580 590 600
TQEPCSLIYN KENKSTFEKQ LNQLKENAKQ QLLNKGFPEE EIFCEGFLNL
610 620 630 640 650
RFSGTDTAMM IKTPDNHDYE AEFKSNYKRE FGFLILGRDL LIDDIRVRVH
660 670 680 690 700
ARGSDLNSLR INDSTGEPLK PETIQKCYFE SVGRIDTPIY LLKSLCGGDS
710 720 730 740 750
IDGPAIIIDN TTTIVVEPNC KANILKPSGN IEILIGGGKS KTVTTELDPI
760 770 780 790 800
MLSVFSHRFM SIAEQMGKII IRTSISTNIK ERLDFSCALF SPDGGLVANA
810 820 830 840 850
PAIPIHVGSM QNAVKYQVET LGSNWKEGEV VLSNHPQAGG SHLPDLTVMT
860 870 880 890 900
PVYHKGEIVF FVASRGHHAD IGGITPGSMP PFSKSISEEG AAIMSLKIVK
910 920 930 940 950
DGHFQEEAVR KTFEKSRNLS DNISDLKAQI AANHKGIQLM QELINHYGLD
960 970 980 990 1000
VVHAYMYHIQ KNAELAVRDM LYDISISNNL KPLDTLISTD YMDDGSKIEL
1010 1020 1030 1040 1050
KLTIDREKKS AIFDWSGSGV EVYGNTNAPT SITLSATIYS LRAMVKSEIP
1060 1070 1080 1090 1100
LNQGCLAPIL TVIPPGSILN PSFDSAVVGG NVLTSQRLTD VILSAFGACA
1110 1120 1130 1140 1150
NSQGCMNNLT FGDETLGYYE TIAGGTGAGP NFNGFTAVQS HMTNTRITDV
1160 1170 1180 1190 1200
EIMEKRYPVI VKEFSVRYGS GGDGKFKGGD GVVREIQFLK NFTVSILSER
1210 1220 1230 1240 1250
RSLQPRGLMG GENAERGLNL VLKNNGKYIN IGSKNSINIE RNESIIIFTP
1260
GGGGFGQKDS MITDN
Length:1,265
Mass (Da):138,977
Last modified:June 16, 2009 - v2
Checksum:i8CF76C8FB996D271
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64940.2.
RefSeqiXP_639951.2. XM_634859.2.

Genome annotation databases

EnsemblProtistsiDDB0304678; DDB0304678; DDB_G0284953.
GeneIDi8624863.
KEGGiddi:DDB_G0284953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64940.2 .
RefSeqi XP_639951.2. XM_634859.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0186276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0304678 ; DDB0304678 ; DDB_G0284953 .
GeneIDi 8624863.
KEGGi ddi:DDB_G0284953.

Organism-specific databases

dictyBasei DDB_G0284953. oplah.

Phylogenomic databases

eggNOGi COG0146.
InParanoidi Q54NW6.
KOi K01469.
OMAi VEAYMGH.
PhylomeDBi Q54NW6.

Enzyme and pathway databases

Reactomei REACT_206208. Glutathione synthesis and recycling.

Miscellaneous databases

PROi Q54NW6.

Family and domain databases

InterProi IPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view ]
Pfami PF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiOPLA_DICDI
AccessioniPrimary (citable) accession number: Q54NW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3