Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q54NW6

- OPLA_DICDI

UniProt

Q54NW6 - OPLA_DICDI

Protein

5-oxoprolinase

Gene

oplah

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.By similarity

    Catalytic activityi

    ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

    GO - Molecular functioni

    1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_206208. Glutathione synthesis and recycling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-oxoprolinase (EC:3.5.2.9)
    Alternative name(s):
    5-oxo-L-prolinase
    Short name:
    5-OPase
    Pyroglutamase
    Gene namesi
    Name:oplah
    ORF Names:DDB_G0284953
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0284953. oplah.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 126512655-oxoprolinasePRO_0000328515Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0186276.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the oxoprolinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0146.
    KOiK01469.
    OMAiVEAYMGH.
    PhylomeDBiQ54NW6.

    Family and domain databases

    InterProiIPR008040. Hydant_A_N.
    IPR002821. Hydantoinase_A.
    IPR003692. Hydantoinase_B.
    [Graphical view]
    PfamiPF05378. Hydant_A_N. 1 hit.
    PF01968. Hydantoinase_A. 1 hit.
    PF02538. Hydantoinase_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54NW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIDKLKKSI KFNIDRGGTF TDIYAEFPYE PYYIVEKLLS VDPENYSDAP     50
    REGIRRILER IQGKSISKEN VDTYAIKSIR MGTTVGTNAL LERKGEKVLL 100
    VTSKGFRDLL QIGNQSRPKI FELNITKPEL IYNSVVELDE RVQIVTNDQV 150
    LNDIKLESPN SLKKGTTGDY IKVLEIPNRD KIKSELLKYF VKGIKSIAVV 200
    FIHSYTFHDH ELLVGEIAKE IGFEHISLSH QLMPMIKAVP RGLTSCVDAY 250
    LTPLIELYIK NFTKGFDSNI GDVDISFMMS DGGLCPVDSF RGFRSILSGP 300
    AGGVVGYSKT TSTVIESHKN NNGNNEIKQQ PIIGFDMGGT STDVSRYNGT 350
    LDHVFETEIS GLTIQAPQLD IHTVAAGGGS RLFFKSGLFL VGPESVGAHP 400
    GPVCYKKNGQ LAITDANLLL GRLLPEYFPP IFGPNQNEPL DLEATKKAFK 450
    ELTDEINQFQ QNNNLPLMTE DQVAFGFIRV ANEAMCRPIR NITEAKGFDC 500
    SQHVLACFGG AGGQHSCSIA QNLGMPKVFI HRFSGILSAY GLGLADLVID 550
    TQEPCSLIYN KENKSTFEKQ LNQLKENAKQ QLLNKGFPEE EIFCEGFLNL 600
    RFSGTDTAMM IKTPDNHDYE AEFKSNYKRE FGFLILGRDL LIDDIRVRVH 650
    ARGSDLNSLR INDSTGEPLK PETIQKCYFE SVGRIDTPIY LLKSLCGGDS 700
    IDGPAIIIDN TTTIVVEPNC KANILKPSGN IEILIGGGKS KTVTTELDPI 750
    MLSVFSHRFM SIAEQMGKII IRTSISTNIK ERLDFSCALF SPDGGLVANA 800
    PAIPIHVGSM QNAVKYQVET LGSNWKEGEV VLSNHPQAGG SHLPDLTVMT 850
    PVYHKGEIVF FVASRGHHAD IGGITPGSMP PFSKSISEEG AAIMSLKIVK 900
    DGHFQEEAVR KTFEKSRNLS DNISDLKAQI AANHKGIQLM QELINHYGLD 950
    VVHAYMYHIQ KNAELAVRDM LYDISISNNL KPLDTLISTD YMDDGSKIEL 1000
    KLTIDREKKS AIFDWSGSGV EVYGNTNAPT SITLSATIYS LRAMVKSEIP 1050
    LNQGCLAPIL TVIPPGSILN PSFDSAVVGG NVLTSQRLTD VILSAFGACA 1100
    NSQGCMNNLT FGDETLGYYE TIAGGTGAGP NFNGFTAVQS HMTNTRITDV 1150
    EIMEKRYPVI VKEFSVRYGS GGDGKFKGGD GVVREIQFLK NFTVSILSER 1200
    RSLQPRGLMG GENAERGLNL VLKNNGKYIN IGSKNSINIE RNESIIIFTP 1250
    GGGGFGQKDS MITDN 1265
    Length:1,265
    Mass (Da):138,977
    Last modified:June 16, 2009 - v2
    Checksum:i8CF76C8FB996D271
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000073 Genomic DNA. Translation: EAL64940.2.
    RefSeqiXP_639951.2. XM_634859.2.

    Genome annotation databases

    EnsemblProtistsiDDB0304678; DDB0304678; DDB_G0284953.
    GeneIDi8624863.
    KEGGiddi:DDB_G0284953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000073 Genomic DNA. Translation: EAL64940.2 .
    RefSeqi XP_639951.2. XM_634859.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0186276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0304678 ; DDB0304678 ; DDB_G0284953 .
    GeneIDi 8624863.
    KEGGi ddi:DDB_G0284953.

    Organism-specific databases

    dictyBasei DDB_G0284953. oplah.

    Phylogenomic databases

    eggNOGi COG0146.
    KOi K01469.
    OMAi VEAYMGH.
    PhylomeDBi Q54NW6.

    Enzyme and pathway databases

    Reactomei REACT_206208. Glutathione synthesis and recycling.

    Miscellaneous databases

    PROi Q54NW6.

    Family and domain databases

    InterProi IPR008040. Hydant_A_N.
    IPR002821. Hydantoinase_A.
    IPR003692. Hydantoinase_B.
    [Graphical view ]
    Pfami PF05378. Hydant_A_N. 1 hit.
    PF01968. Hydantoinase_A. 1 hit.
    PF02538. Hydantoinase_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiOPLA_DICDI
    AccessioniPrimary (citable) accession number: Q54NW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3