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Q54NW6 (OPLA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-oxoprolinase

EC=3.5.2.9
Alternative name(s):
5-oxo-L-prolinase
Short name=5-OPase
Pyroglutamase
Gene names
Name:oplah
ORF Names:DDB_G0284953
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate By similarity.

Catalytic activity

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the oxoprolinase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_function5-oxoprolinase (ATP-hydrolyzing) activity

Inferred from electronic annotation. Source: UniProtKB-EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 126512655-oxoprolinase
PRO_0000328515

Sequences

Sequence LengthMass (Da)Tools
Q54NW6 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: 8CF76C8FB996D271

FASTA1,265138,977
        10         20         30         40         50         60 
MTIDKLKKSI KFNIDRGGTF TDIYAEFPYE PYYIVEKLLS VDPENYSDAP REGIRRILER 

        70         80         90        100        110        120 
IQGKSISKEN VDTYAIKSIR MGTTVGTNAL LERKGEKVLL VTSKGFRDLL QIGNQSRPKI 

       130        140        150        160        170        180 
FELNITKPEL IYNSVVELDE RVQIVTNDQV LNDIKLESPN SLKKGTTGDY IKVLEIPNRD 

       190        200        210        220        230        240 
KIKSELLKYF VKGIKSIAVV FIHSYTFHDH ELLVGEIAKE IGFEHISLSH QLMPMIKAVP 

       250        260        270        280        290        300 
RGLTSCVDAY LTPLIELYIK NFTKGFDSNI GDVDISFMMS DGGLCPVDSF RGFRSILSGP 

       310        320        330        340        350        360 
AGGVVGYSKT TSTVIESHKN NNGNNEIKQQ PIIGFDMGGT STDVSRYNGT LDHVFETEIS 

       370        380        390        400        410        420 
GLTIQAPQLD IHTVAAGGGS RLFFKSGLFL VGPESVGAHP GPVCYKKNGQ LAITDANLLL 

       430        440        450        460        470        480 
GRLLPEYFPP IFGPNQNEPL DLEATKKAFK ELTDEINQFQ QNNNLPLMTE DQVAFGFIRV 

       490        500        510        520        530        540 
ANEAMCRPIR NITEAKGFDC SQHVLACFGG AGGQHSCSIA QNLGMPKVFI HRFSGILSAY 

       550        560        570        580        590        600 
GLGLADLVID TQEPCSLIYN KENKSTFEKQ LNQLKENAKQ QLLNKGFPEE EIFCEGFLNL 

       610        620        630        640        650        660 
RFSGTDTAMM IKTPDNHDYE AEFKSNYKRE FGFLILGRDL LIDDIRVRVH ARGSDLNSLR 

       670        680        690        700        710        720 
INDSTGEPLK PETIQKCYFE SVGRIDTPIY LLKSLCGGDS IDGPAIIIDN TTTIVVEPNC 

       730        740        750        760        770        780 
KANILKPSGN IEILIGGGKS KTVTTELDPI MLSVFSHRFM SIAEQMGKII IRTSISTNIK 

       790        800        810        820        830        840 
ERLDFSCALF SPDGGLVANA PAIPIHVGSM QNAVKYQVET LGSNWKEGEV VLSNHPQAGG 

       850        860        870        880        890        900 
SHLPDLTVMT PVYHKGEIVF FVASRGHHAD IGGITPGSMP PFSKSISEEG AAIMSLKIVK 

       910        920        930        940        950        960 
DGHFQEEAVR KTFEKSRNLS DNISDLKAQI AANHKGIQLM QELINHYGLD VVHAYMYHIQ 

       970        980        990       1000       1010       1020 
KNAELAVRDM LYDISISNNL KPLDTLISTD YMDDGSKIEL KLTIDREKKS AIFDWSGSGV 

      1030       1040       1050       1060       1070       1080 
EVYGNTNAPT SITLSATIYS LRAMVKSEIP LNQGCLAPIL TVIPPGSILN PSFDSAVVGG 

      1090       1100       1110       1120       1130       1140 
NVLTSQRLTD VILSAFGACA NSQGCMNNLT FGDETLGYYE TIAGGTGAGP NFNGFTAVQS 

      1150       1160       1170       1180       1190       1200 
HMTNTRITDV EIMEKRYPVI VKEFSVRYGS GGDGKFKGGD GVVREIQFLK NFTVSILSER 

      1210       1220       1230       1240       1250       1260 
RSLQPRGLMG GENAERGLNL VLKNNGKYIN IGSKNSINIE RNESIIIFTP GGGGFGQKDS 


MITDN 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000073 Genomic DNA. Translation: EAL64940.2.
RefSeqXP_639951.2. XM_634859.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0186276.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0304678; DDB0304678; DDB_G0284953.
GeneID8624863.
KEGGddi:DDB_G0284953.

Organism-specific databases

dictyBaseDDB_G0284953. oplah.

Phylogenomic databases

eggNOGCOG0146.
OMAVEAYMGH.
PhylomeDBQ54NW6.

Family and domain databases

InterProIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54NW6.

Entry information

Entry nameOPLA_DICDI
AccessionPrimary (citable) accession number: Q54NW6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase