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Q54NW6

- OPLA_DICDI

UniProt

Q54NW6 - OPLA_DICDI

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Protein
5-oxoprolinase
Gene
oplah, DDB_G0284953
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate By similarity.

Catalytic activityi

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

GO - Molecular functioni

  1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_206208. Glutathione synthesis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Pyroglutamase
Gene namesi
Name:oplah
ORF Names:DDB_G0284953
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284953. oplah.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126512655-oxoprolinase
PRO_0000328515Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0186276.

Family & Domainsi

Sequence similaritiesi

Belongs to the oxoprolinase family.

Phylogenomic databases

eggNOGiCOG0146.
KOiK01469.
OMAiVEAYMGH.
PhylomeDBiQ54NW6.

Family and domain databases

InterProiIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamiPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54NW6-1 [UniParc]FASTAAdd to Basket

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MTIDKLKKSI KFNIDRGGTF TDIYAEFPYE PYYIVEKLLS VDPENYSDAP     50
REGIRRILER IQGKSISKEN VDTYAIKSIR MGTTVGTNAL LERKGEKVLL 100
VTSKGFRDLL QIGNQSRPKI FELNITKPEL IYNSVVELDE RVQIVTNDQV 150
LNDIKLESPN SLKKGTTGDY IKVLEIPNRD KIKSELLKYF VKGIKSIAVV 200
FIHSYTFHDH ELLVGEIAKE IGFEHISLSH QLMPMIKAVP RGLTSCVDAY 250
LTPLIELYIK NFTKGFDSNI GDVDISFMMS DGGLCPVDSF RGFRSILSGP 300
AGGVVGYSKT TSTVIESHKN NNGNNEIKQQ PIIGFDMGGT STDVSRYNGT 350
LDHVFETEIS GLTIQAPQLD IHTVAAGGGS RLFFKSGLFL VGPESVGAHP 400
GPVCYKKNGQ LAITDANLLL GRLLPEYFPP IFGPNQNEPL DLEATKKAFK 450
ELTDEINQFQ QNNNLPLMTE DQVAFGFIRV ANEAMCRPIR NITEAKGFDC 500
SQHVLACFGG AGGQHSCSIA QNLGMPKVFI HRFSGILSAY GLGLADLVID 550
TQEPCSLIYN KENKSTFEKQ LNQLKENAKQ QLLNKGFPEE EIFCEGFLNL 600
RFSGTDTAMM IKTPDNHDYE AEFKSNYKRE FGFLILGRDL LIDDIRVRVH 650
ARGSDLNSLR INDSTGEPLK PETIQKCYFE SVGRIDTPIY LLKSLCGGDS 700
IDGPAIIIDN TTTIVVEPNC KANILKPSGN IEILIGGGKS KTVTTELDPI 750
MLSVFSHRFM SIAEQMGKII IRTSISTNIK ERLDFSCALF SPDGGLVANA 800
PAIPIHVGSM QNAVKYQVET LGSNWKEGEV VLSNHPQAGG SHLPDLTVMT 850
PVYHKGEIVF FVASRGHHAD IGGITPGSMP PFSKSISEEG AAIMSLKIVK 900
DGHFQEEAVR KTFEKSRNLS DNISDLKAQI AANHKGIQLM QELINHYGLD 950
VVHAYMYHIQ KNAELAVRDM LYDISISNNL KPLDTLISTD YMDDGSKIEL 1000
KLTIDREKKS AIFDWSGSGV EVYGNTNAPT SITLSATIYS LRAMVKSEIP 1050
LNQGCLAPIL TVIPPGSILN PSFDSAVVGG NVLTSQRLTD VILSAFGACA 1100
NSQGCMNNLT FGDETLGYYE TIAGGTGAGP NFNGFTAVQS HMTNTRITDV 1150
EIMEKRYPVI VKEFSVRYGS GGDGKFKGGD GVVREIQFLK NFTVSILSER 1200
RSLQPRGLMG GENAERGLNL VLKNNGKYIN IGSKNSINIE RNESIIIFTP 1250
GGGGFGQKDS MITDN 1265
Length:1,265
Mass (Da):138,977
Last modified:June 16, 2009 - v2
Checksum:i8CF76C8FB996D271
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64940.2.
RefSeqiXP_639951.2. XM_634859.2.

Genome annotation databases

EnsemblProtistsiDDB0304678; DDB0304678; DDB_G0284953.
GeneIDi8624863.
KEGGiddi:DDB_G0284953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64940.2 .
RefSeqi XP_639951.2. XM_634859.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0186276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0304678 ; DDB0304678 ; DDB_G0284953 .
GeneIDi 8624863.
KEGGi ddi:DDB_G0284953.

Organism-specific databases

dictyBasei DDB_G0284953. oplah.

Phylogenomic databases

eggNOGi COG0146.
KOi K01469.
OMAi VEAYMGH.
PhylomeDBi Q54NW6.

Enzyme and pathway databases

Reactomei REACT_206208. Glutathione synthesis and recycling.

Miscellaneous databases

PROi Q54NW6.

Family and domain databases

InterProi IPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view ]
Pfami PF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiOPLA_DICDI
AccessioniPrimary (citable) accession number: Q54NW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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