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Q54NU9

- TPSB_DICDI

UniProt

Q54NU9 - TPSB_DICDI

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Protein
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] B
Gene
tpsB, DDB_G0284975
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Synthesizes trehalose 6-phosphate, the precursor for the production of trehalose, the main carbohydrate storage reserve of the dormant spore. Trehalose accumulates in both prestalk and prespore cells and then is rapidly metabolized during terminal differentiation of stalk cells, while being stored in spores, where it serves as the principal energy and carbon source for germination.1 Publication

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] B (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase B
UDP-glucose-glucosephosphate glucosyltransferase B
Gene namesi
Name:tpsB
ORF Names:DDB_G0284975
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0284975. tpsB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Alpha,alpha-trehalose-phosphate synthase [UDP-forming] B
PRO_0000328411Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231987.

Structurei

3D structure databases

ProteinModelPortaliQ54NU9.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.
In the C-terminal section; belongs to the trehalose phosphatase family.

Phylogenomic databases

eggNOGiCOG0380.
KOiK16055.
OMAiCAKNEAT.
PhylomeDBiQ54NU9.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR003337. Trehalose_PPase.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
TIGR00685. T6PP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54NU9-1 [UniParc]FASTAAdd to Basket

« Hide

MTIIQRSTSL NNIINEKLGK IIVASNTLPI TVTKFNETPL FGSPLSASRE    50
SITSSFGMSE PSRDRESKIQ IQINGHPFPT QSALETLKAK DEIEDWLWIG 100
WSHCEVNEDE EPMLNQAIKE FSPHFEHVFL NPRQFENYYK GYCKNGLWLL 150
LHYQMNFIRM QSEWWEEYVG VNQMFAEKIA SVWRPSDIIW IHDYHLMLVP 200
QMLRQLLPPE ASIGFFFHAP FPSYELFRIL PNRKELLKGI LSSNLIGFQS 250
FEYVRHFKSS CARLLDLEVH PKGLEIFEDG STHFTKLQVY PIGVDYNDFA 300
KNLNLPEVSS RVESLRKIFK GKKVVVARDR LDQIEGVPRK LEVFEQLLND 350
HPEYIGKLVF IQIYEPTVEE GDETDEQKIL HKTVNEMVGR INGKFGKLSF 400
NPIEYINKKI SYEELSALYK LADIALITPI RDGMNLTSHE YVVCQKDNFG 450
VLILSEFAGA ARCLGGSIIV NPFSKKEIME AIIEALNMSM HDRKLKHQIN 500
YNYVLANTSS FWGKRFLCDL NEATQKEIME TSVPRANFQE IEDSYKKAKV 550
RVFFLDYDGT LTPLVRLPSQ AMPSKQLIDV LSKLTEDRRN EVYVISGRDR 600
SSLEKWLGHL PIGMSCEHGV FTRQPGENQP WTESPNAEVQ WKDTVLSIMQ 650
DFEDRTPGSM TETKQVNITW HYRNADPDFG QFQAKELIAQ LRSVANKYPL 700
DILSGKKAIE VKPIGINKGE IVKMILQKID ADFILCIGDD KTDEDMFKAL 750
YNVPSFTIRV CGDLEESTKA RGVVESSSEV LTLLNRLSLS 790
Length:790
Mass (Da):90,775
Last modified:May 24, 2005 - v1
Checksum:iEA8E23A53F6DADB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64951.1.
RefSeqiXP_639968.1. XM_634876.1.

Genome annotation databases

EnsemblProtistsiDDB0231987; DDB0231987; DDB_G0284975.
GeneIDi8624879.
KEGGiddi:DDB_G0284975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000073 Genomic DNA. Translation: EAL64951.1 .
RefSeqi XP_639968.1. XM_634876.1.

3D structure databases

ProteinModelPortali Q54NU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231987 ; DDB0231987 ; DDB_G0284975 .
GeneIDi 8624879.
KEGGi ddi:DDB_G0284975.

Organism-specific databases

dictyBasei DDB_G0284975. tpsB.

Phylogenomic databases

eggNOGi COG0380.
KOi K16055.
OMAi CAKNEAT.
PhylomeDBi Q54NU9.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR003337. Trehalose_PPase.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
TIGR00685. T6PP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Trehalose 6-phosphate synthase from Dictyostelium discoideum: partial purification and characterization of the enzyme from young sorocarps."
    Killick K.A.
    Arch. Biochem. Biophys. 196:121-133(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTPSB_DICDI
AccessioniPrimary (citable) accession number: Q54NU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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