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Q54NU9

- TPSB_DICDI

UniProt

Q54NU9 - TPSB_DICDI

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] B

Gene

tpsB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Synthesizes trehalose 6-phosphate, the precursor for the production of trehalose, the main carbohydrate storage reserve of the dormant spore. Trehalose accumulates in both prestalk and prespore cells and then is rapidly metabolized during terminal differentiation of stalk cells, while being stored in spores, where it serves as the principal energy and carbon source for germination.1 Publication

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. trehalose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] B (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase B
    UDP-glucose-glucosephosphate glucosyltransferase B
    Gene namesi
    Name:tpsB
    ORF Names:DDB_G0284975
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0284975. tpsB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 790790Alpha,alpha-trehalose-phosphate synthase [UDP-forming] BPRO_0000328411Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231987.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54NU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
    In the C-terminal section; belongs to the trehalose phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    KOiK16055.
    OMAiCAKNEAT.
    PhylomeDBiQ54NU9.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR003337. Trehalose_PPase.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    PF02358. Trehalose_PPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
    TIGR00685. T6PP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54NU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIIQRSTSL NNIINEKLGK IIVASNTLPI TVTKFNETPL FGSPLSASRE    50
    SITSSFGMSE PSRDRESKIQ IQINGHPFPT QSALETLKAK DEIEDWLWIG 100
    WSHCEVNEDE EPMLNQAIKE FSPHFEHVFL NPRQFENYYK GYCKNGLWLL 150
    LHYQMNFIRM QSEWWEEYVG VNQMFAEKIA SVWRPSDIIW IHDYHLMLVP 200
    QMLRQLLPPE ASIGFFFHAP FPSYELFRIL PNRKELLKGI LSSNLIGFQS 250
    FEYVRHFKSS CARLLDLEVH PKGLEIFEDG STHFTKLQVY PIGVDYNDFA 300
    KNLNLPEVSS RVESLRKIFK GKKVVVARDR LDQIEGVPRK LEVFEQLLND 350
    HPEYIGKLVF IQIYEPTVEE GDETDEQKIL HKTVNEMVGR INGKFGKLSF 400
    NPIEYINKKI SYEELSALYK LADIALITPI RDGMNLTSHE YVVCQKDNFG 450
    VLILSEFAGA ARCLGGSIIV NPFSKKEIME AIIEALNMSM HDRKLKHQIN 500
    YNYVLANTSS FWGKRFLCDL NEATQKEIME TSVPRANFQE IEDSYKKAKV 550
    RVFFLDYDGT LTPLVRLPSQ AMPSKQLIDV LSKLTEDRRN EVYVISGRDR 600
    SSLEKWLGHL PIGMSCEHGV FTRQPGENQP WTESPNAEVQ WKDTVLSIMQ 650
    DFEDRTPGSM TETKQVNITW HYRNADPDFG QFQAKELIAQ LRSVANKYPL 700
    DILSGKKAIE VKPIGINKGE IVKMILQKID ADFILCIGDD KTDEDMFKAL 750
    YNVPSFTIRV CGDLEESTKA RGVVESSSEV LTLLNRLSLS 790
    Length:790
    Mass (Da):90,775
    Last modified:May 24, 2005 - v1
    Checksum:iEA8E23A53F6DADB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000073 Genomic DNA. Translation: EAL64951.1.
    RefSeqiXP_639968.1. XM_634876.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231987; DDB0231987; DDB_G0284975.
    GeneIDi8624879.
    KEGGiddi:DDB_G0284975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000073 Genomic DNA. Translation: EAL64951.1 .
    RefSeqi XP_639968.1. XM_634876.1.

    3D structure databases

    ProteinModelPortali Q54NU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231987 ; DDB0231987 ; DDB_G0284975 .
    GeneIDi 8624879.
    KEGGi ddi:DDB_G0284975.

    Organism-specific databases

    dictyBasei DDB_G0284975. tpsB.

    Phylogenomic databases

    eggNOGi COG0380.
    KOi K16055.
    OMAi CAKNEAT.
    PhylomeDBi Q54NU9.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR003337. Trehalose_PPase.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    PF02358. Trehalose_PPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    TIGR00685. T6PP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "Trehalose 6-phosphate synthase from Dictyostelium discoideum: partial purification and characterization of the enzyme from young sorocarps."
      Killick K.A.
      Arch. Biochem. Biophys. 196:121-133(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTPSB_DICDI
    AccessioniPrimary (citable) accession number: Q54NU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3