Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q54NG9

- SCPDH_DICDI

UniProt

Q54NG9 - SCPDH_DICDI

Protein

Probable saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

Gene

sdh

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Source: dictyBase
    2. saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00033; UER00033.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable saccharopine dehydrogenase [NADP(+), L-glutamate-forming] (EC:1.5.1.10)
    Alternative name(s):
    Saccharopine reductase
    Gene namesi
    Name:sdh
    ORF Names:DDB_G0285267
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0285267. sdh.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Probable saccharopine dehydrogenase [NADP(+), L-glutamate-forming]PRO_0000365593Add
    BLAST

    Proteomic databases

    PRIDEiQ54NG9.

    Expressioni

    Developmental stagei

    Up-regulated in aspidocytes, environmentally resistant cell types.1 Publication

    Inductioni

    Down-regulated by phagocytic stimuli.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0186419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54NG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the saccharopine dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1748.
    KOiK00293.
    OMAiYAVKTIE.
    PhylomeDBiQ54NG9.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR005097. Saccharopine_DH/HSpermid_syn.
    [Graphical view]
    PfamiPF03435. Saccharop_dh. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54NG9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNILLLGSG FVAKPALDYL LKREDYFVTI VSLFQNELDS ITKGHDTSKF    50
    KTIQLDVMNK LNELEEYFPK SDCVISLIPA TLHSTVAKLC IKHKTHLVTA 100
    SYISDDMKAL SEEAKEAGVL LLNELGLDPG IDHMSSMKII DHAKENGGKV 150
    TSFVSWCGAL PSTECADNPF GYKFSWSPRG VLSSATLSAN FLWEGHNEEV 200
    PANIKWAVLQ PIVVEDSNGV KMEFDGVPNR NSFPYIEQYN LNAKDVTTMF 250
    RGTLRWKGGF GIMIRALVAV GLFSTEVDAR LAVEGGISWR NYLVQLLGCN 300
    DNDSDLLYCV ESTIKEYFEK LKTERDGLQF HFPIIPRDIE KDVQHAVEGF 350
    KWLGLLSADE KVVNKNTPID SLCALLEKKL SYKAGERDVV VLEHNFVVQY 400
    ADRTEKEVSS LICYGIPNGS SATSLTVGVP VGIATELIAD GKTTTRGVVG 450
    PVTPEFYLPI LEKLKSENIE MIETKQEIKK 480
    Length:480
    Mass (Da):53,359
    Last modified:May 24, 2005 - v1
    Checksum:i10EE7E6746F7F894
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000077 Genomic DNA. Translation: EAL64797.1.
    RefSeqiXP_638300.1. XM_633208.1.

    Genome annotation databases

    EnsemblProtistsiDDB0238270; DDB0238270; DDB_G0285267.
    GeneIDi8625017.
    KEGGiddi:DDB_G0285267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000077 Genomic DNA. Translation: EAL64797.1 .
    RefSeqi XP_638300.1. XM_633208.1.

    3D structure databases

    ProteinModelPortali Q54NG9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0186419.

    Proteomic databases

    PRIDEi Q54NG9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0238270 ; DDB0238270 ; DDB_G0285267 .
    GeneIDi 8625017.
    KEGGi ddi:DDB_G0285267.

    Organism-specific databases

    dictyBasei DDB_G0285267. sdh.

    Phylogenomic databases

    eggNOGi COG1748.
    KOi K00293.
    OMAi YAVKTIE.
    PhylomeDBi Q54NG9.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00033 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR005097. Saccharopine_DH/HSpermid_syn.
    [Graphical view ]
    Pfami PF03435. Saccharop_dh. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "A new environmentally resistant cell type from Dictyostelium."
      Serafimidis I., Bloomfield G., Skelton J., Ivens A., Kay R.R.
      Microbiology 153:619-630(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    3. "Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium."
      Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B., Skelton J., Ivens A., Bozzaro S.
      BMC Genomics 9:291-291(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSCPDH_DICDI
    AccessioniPrimary (citable) accession number: Q54NG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3