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Q54NG9 (SCPDH_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

EC=1.5.1.10
Alternative name(s):
Saccharopine reductase
Gene names
Name:sdh
ORF Names:DDB_G0285267
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.

Developmental stage

Up-regulated in aspidocytes, environmentally resistant cell types. Ref.2

Induction

Down-regulated by phagocytic stimuli.

Sequence similarities

Belongs to the saccharopine dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Probable saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
PRO_0000365593

Sequences

Sequence LengthMass (Da)Tools
Q54NG9 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 10EE7E6746F7F894

FASTA48053,359
        10         20         30         40         50         60 
MKNILLLGSG FVAKPALDYL LKREDYFVTI VSLFQNELDS ITKGHDTSKF KTIQLDVMNK 

        70         80         90        100        110        120 
LNELEEYFPK SDCVISLIPA TLHSTVAKLC IKHKTHLVTA SYISDDMKAL SEEAKEAGVL 

       130        140        150        160        170        180 
LLNELGLDPG IDHMSSMKII DHAKENGGKV TSFVSWCGAL PSTECADNPF GYKFSWSPRG 

       190        200        210        220        230        240 
VLSSATLSAN FLWEGHNEEV PANIKWAVLQ PIVVEDSNGV KMEFDGVPNR NSFPYIEQYN 

       250        260        270        280        290        300 
LNAKDVTTMF RGTLRWKGGF GIMIRALVAV GLFSTEVDAR LAVEGGISWR NYLVQLLGCN 

       310        320        330        340        350        360 
DNDSDLLYCV ESTIKEYFEK LKTERDGLQF HFPIIPRDIE KDVQHAVEGF KWLGLLSADE 

       370        380        390        400        410        420 
KVVNKNTPID SLCALLEKKL SYKAGERDVV VLEHNFVVQY ADRTEKEVSS LICYGIPNGS 

       430        440        450        460        470        480 
SATSLTVGVP VGIATELIAD GKTTTRGVVG PVTPEFYLPI LEKLKSENIE MIETKQEIKK 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"A new environmentally resistant cell type from Dictyostelium."
Serafimidis I., Bloomfield G., Skelton J., Ivens A., Kay R.R.
Microbiology 153:619-630(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[3]"Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium."
Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B., Skelton J., Ivens A., Bozzaro S.
BMC Genomics 9:291-291(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000077 Genomic DNA. Translation: EAL64797.1.

3D structure databases

ProteinModelPortalQ54NG9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0186419.

Proteomic databases

PRIDEQ54NG9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0238270; DDB0238270; DDB_G0285267.
KEGGddi:DDB_G0285267.

Organism-specific databases

dictyBaseDDB_G0285267. sdh.

Phylogenomic databases

eggNOGCOG1748.
KOK00293.
OMAYAVKTIE.
PhylomeDBQ54NG9.

Enzyme and pathway databases

UniPathwayUPA00033; UER00033.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR016040. NAD(P)-bd_dom.
IPR005097. Saccharopine_DH/HSpermid_syn.
[Graphical view]
PfamPF03435. Saccharop_dh. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSCPDH_DICDI
AccessionPrimary (citable) accession number: Q54NG9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase