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Protein

Probable phosphoglycerate mutase

Gene

gpmA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.By similarity
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10Tele-phosphohistidine intermediateBy similarity1
Binding sitei61SubstrateBy similarity1
Active sitei88Proton donor/acceptorBy similarity1
Binding sitei99SubstrateBy similarity1
Sitei183Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Isomerase
Biological processGlycolysis

Enzyme and pathway databases

BRENDAi3.1.3.80 1939
ReactomeiR-DDI-6798695 Neutrophil degranulation
R-DDI-70171 Glycolysis
R-DDI-70263 Gluconeogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglycerate mutase (EC:5.4.2.11By similarity, EC:5.4.2.4By similarity)
Alternative name(s):
BPG-dependent PGAM
Short name:
dPGM
Gene namesi
Name:gpmA
Synonyms:pgam
ORF Names:DDB_G0285311
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285311 gpmA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003280741 – 249Probable phosphoglycerate mutaseAdd BLAST249

Proteomic databases

PaxDbiQ54NE6
PRIDEiQ54NE6

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231354

Structurei

3D structure databases

ProteinModelPortaliQ54NE6
SMRiQ54NE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 16Substrate bindingBy similarity8
Regioni22 – 23Substrate bindingBy similarity2
Regioni88 – 91Substrate bindingBy similarity4
Regioni115 – 116Substrate bindingBy similarity2
Regioni184 – 185Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0235 Eukaryota
COG0588 LUCA
InParanoidiQ54NE6
KOiK01834
OMAiRMLPYWY
PhylomeDBiQ54NE6

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.12401 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q54NE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYKLVLIRH GESTWNKENK FTGWTDVDLS EKGVQEAHEA GKRLLKAGFT
60 70 80 90 100
FDIAYTSVLK RAIRTLWILL EELNLYWIPV SRQWRLNERM YGSLQGLNKS
110 120 130 140 150
ETAAKYGEDQ VLIWRRSYDI PPPALEESDE RYPGNDPRYA KLDKSDLPKT
160 170 180 190 200
ECLKDTVERF LPLWNDTIAP TIKSGQKVLI AAHGNSIRAL VKYLDNIADD
210 220 230 240
KIVSMDIPTG IPLVYELDEN LKPIKHYYLA DESELNAAIQ AVANQGKAK
Length:249
Mass (Da):28,480
Last modified:May 24, 2005 - v1
Checksum:iA1C3FA1FA891F37E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000078 Genomic DNA Translation: EAL64785.1
RefSeqiXP_638289.1, XM_633197.1

Genome annotation databases

EnsemblProtistsiEAL64785; EAL64785; DDB_G0285311
GeneIDi8625042
KEGGiddi:DDB_G0285311

Similar proteinsi

Entry informationi

Entry nameiPGAM_DICDI
AccessioniPrimary (citable) accession number: Q54NE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome