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Q54N83 (SYLC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase, cytoplasmic

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
ORF Names:DDB_G0285451
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1058 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10581058Leucine--tRNA ligase, cytoplasmic
PRO_0000328291

Regions

Motif48 – 5811"HIGH" region By similarity
Motif711 – 7155"KMSKS" region By similarity

Sites

Binding site7141ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54N83 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 62D8D2139322198E

FASTA1,058119,529
        10         20         30         40         50         60 
MSTAKLDFVR AYEKEVQNKW ESDKQFEIDA LDAPDAEHPK YLATFPYPYM NGRLHVGHVF 

        70         80         90        100        110        120 
TITKAEFMCQ FQRLMGKRVL FPFAFHCTGM PIKACADKLK KEIEQFGCPP VFPVIEEKPI 

       130        140        150        160        170        180 
QEVTTAVKED PLSFKSKKTK AVAKSGGAVY QWKIMQSLGI SDEEIPMFAD SAYWLNYFPP 

       190        200        210        220        230        240 
HCESDLKLLG VGVDWRRSFI TTDVNGYYDS FVRWQFESLK ALGKVKYGKR YSIWSTIDDQ 

       250        260        270        280        290        300 
QCADHERAQG EGVGPQNYTL IKLEVVEPIP ECLKEIHSQG KKIYLVPGTL RPETMYGQTN 

       310        320        330        340        350        360 
CWILPTGKYG AFEMANGDIF VCTERSARNM SYQQMTTGKG EYKCLAKFEG SDILGAALKA 

       370        380        390        400        410        420 
PLAINPIVYV LPMLTIDENK GTGVVTSVPS DSPDDYASLQ DLKAKAPLRA KFSIKDEWVL 

       430        440        450        460        470        480 
PFEVVPIIDI PGYSNESAVR AYKDLGIKSQ NDRALLDQAK DLCYQKGFND GVMSVGPYAG 

       490        500        510        520        530        540 
RKVSEVKKII KDEMVASGQA VDYSEPTSKV VSRSGDECVV ALSDQWYINY GDDDIEWKNQ 

       550        560        570        580        590        600 
TIKQLESMEF YSAETKKKFE IALGWMNQWA CSRSFGLGTH LPWDEKFLIE SLSDSTIYMA 

       610        620        630        640        650        660 
FYTVAHLLQG DVNGSKPGSA GITPKQMTSA CWDYVLMGKP YPEGCEVSEE KLKELKKEFT 

       670        680        690        700        710        720 
YWYPVDIRVS GADLIQNHLT FFLYTHAAIF EKKFQPKSIR ANGFVNLNGE KMSKSTGNFL 

       730        740        750        760        770        780 
TLVDSVAKFS ADGTRVALAD AGDSIEDANF VDQTAVTSLL KLHTQIQWVQ ETLDSIDKFR 

       790        800        810        820        830        840 
SGPLDRIQDT IFESEINNII VESEKAYQKT NFRDALHLVF FDLQNARDHY KVTTLDQMHK 

       850        860        870        880        890        900 
DLVLRFIEVQ ALLIYPIAPH FAQKLFNMLG KGNILSAGWP KAGAIDYEAL KKNNYVQQTI 

       910        920        930        940        950        960 
YNFRMKLQVY QKAKLKGKPA GTKAIPDQST IIVSKSYPKW QQDVLEYLAT IYNEDSKSFT 

       970        980        990       1000       1010       1020 
KDNNAIAEEL LSREEMKPHK KNLMGFVASA IQNVKESGKD ALQTSLSFDE TSTLTDNIDY 

      1030       1040       1050 
ICKTLELTSF DVKDFNEIPQ ASQSKIQPIP GKPQFQFV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000079 Genomic DNA. Translation: EAL64563.1.
RefSeqXP_638060.1. XM_632968.1.

3D structure databases

ProteinModelPortalQ54N83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231253.

Proteomic databases

PRIDEQ54N83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231253; DDB0231253; DDB_G0285451.
GeneID8625106.
KEGGddi:DDB_G0285451.

Organism-specific databases

dictyBaseDDB_G0285451. leuS.

Phylogenomic databases

eggNOGCOG0495.
OMAFDENVAN.
PhylomeDBQ54N83.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54N83.

Entry information

Entry nameSYLC_DICDI
AccessionPrimary (citable) accession number: Q54N83
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries