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Q54N83

- SYLC_DICDI

UniProt

Q54N83 - SYLC_DICDI

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Protein

Leucine--tRNA ligase, cytoplasmic

Gene
leuS, DDB_G0285451
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei714 – 7141ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. leucine-tRNA ligase activity Source: dictyBase

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
ORF Names:DDB_G0285451
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285451. leuS.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10581058Leucine--tRNA ligase, cytoplasmicPRO_0000328291Add
BLAST

Proteomic databases

PRIDEiQ54N83.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231253.

Structurei

3D structure databases

ProteinModelPortaliQ54N83.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" region By similarityAdd
BLAST
Motifi711 – 7155"KMSKS" region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiFDENVAN.
PhylomeDBiQ54N83.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54N83-1 [UniParc]FASTAAdd to Basket

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MSTAKLDFVR AYEKEVQNKW ESDKQFEIDA LDAPDAEHPK YLATFPYPYM     50
NGRLHVGHVF TITKAEFMCQ FQRLMGKRVL FPFAFHCTGM PIKACADKLK 100
KEIEQFGCPP VFPVIEEKPI QEVTTAVKED PLSFKSKKTK AVAKSGGAVY 150
QWKIMQSLGI SDEEIPMFAD SAYWLNYFPP HCESDLKLLG VGVDWRRSFI 200
TTDVNGYYDS FVRWQFESLK ALGKVKYGKR YSIWSTIDDQ QCADHERAQG 250
EGVGPQNYTL IKLEVVEPIP ECLKEIHSQG KKIYLVPGTL RPETMYGQTN 300
CWILPTGKYG AFEMANGDIF VCTERSARNM SYQQMTTGKG EYKCLAKFEG 350
SDILGAALKA PLAINPIVYV LPMLTIDENK GTGVVTSVPS DSPDDYASLQ 400
DLKAKAPLRA KFSIKDEWVL PFEVVPIIDI PGYSNESAVR AYKDLGIKSQ 450
NDRALLDQAK DLCYQKGFND GVMSVGPYAG RKVSEVKKII KDEMVASGQA 500
VDYSEPTSKV VSRSGDECVV ALSDQWYINY GDDDIEWKNQ TIKQLESMEF 550
YSAETKKKFE IALGWMNQWA CSRSFGLGTH LPWDEKFLIE SLSDSTIYMA 600
FYTVAHLLQG DVNGSKPGSA GITPKQMTSA CWDYVLMGKP YPEGCEVSEE 650
KLKELKKEFT YWYPVDIRVS GADLIQNHLT FFLYTHAAIF EKKFQPKSIR 700
ANGFVNLNGE KMSKSTGNFL TLVDSVAKFS ADGTRVALAD AGDSIEDANF 750
VDQTAVTSLL KLHTQIQWVQ ETLDSIDKFR SGPLDRIQDT IFESEINNII 800
VESEKAYQKT NFRDALHLVF FDLQNARDHY KVTTLDQMHK DLVLRFIEVQ 850
ALLIYPIAPH FAQKLFNMLG KGNILSAGWP KAGAIDYEAL KKNNYVQQTI 900
YNFRMKLQVY QKAKLKGKPA GTKAIPDQST IIVSKSYPKW QQDVLEYLAT 950
IYNEDSKSFT KDNNAIAEEL LSREEMKPHK KNLMGFVASA IQNVKESGKD 1000
ALQTSLSFDE TSTLTDNIDY ICKTLELTSF DVKDFNEIPQ ASQSKIQPIP 1050
GKPQFQFV 1058
Length:1,058
Mass (Da):119,529
Last modified:May 24, 2005 - v1
Checksum:i62D8D2139322198E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000079 Genomic DNA. Translation: EAL64563.1.
RefSeqiXP_638060.1. XM_632968.1.

Genome annotation databases

EnsemblProtistsiDDB0231253; DDB0231253; DDB_G0285451.
GeneIDi8625106.
KEGGiddi:DDB_G0285451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000079 Genomic DNA. Translation: EAL64563.1 .
RefSeqi XP_638060.1. XM_632968.1.

3D structure databases

ProteinModelPortali Q54N83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231253.

Proteomic databases

PRIDEi Q54N83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231253 ; DDB0231253 ; DDB_G0285451 .
GeneIDi 8625106.
KEGGi ddi:DDB_G0285451.

Organism-specific databases

dictyBasei DDB_G0285451. leuS.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi FDENVAN.
PhylomeDBi Q54N83.

Miscellaneous databases

PROi Q54N83.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSYLC_DICDI
AccessioniPrimary (citable) accession number: Q54N83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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