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Protein

Leucine--tRNA ligase, cytoplasmic

Gene

leuS

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei714ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
ORF Names:DDB_G0285451
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285451 leuS

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003282911 – 1058Leucine--tRNA ligase, cytoplasmicAdd BLAST1058

Proteomic databases

PaxDbiQ54N83
PRIDEiQ54N83

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231253

Structurei

3D structure databases

ProteinModelPortaliQ54N83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 58"HIGH" regionBy similarityAdd BLAST11
Motifi711 – 715"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0437 Eukaryota
COG0495 LUCA
InParanoidiQ54N83
KOiK01869
OMAiHVTGTPI
PhylomeDBiQ54N83

Family and domain databases

InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q54N83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAKLDFVR AYEKEVQNKW ESDKQFEIDA LDAPDAEHPK YLATFPYPYM
60 70 80 90 100
NGRLHVGHVF TITKAEFMCQ FQRLMGKRVL FPFAFHCTGM PIKACADKLK
110 120 130 140 150
KEIEQFGCPP VFPVIEEKPI QEVTTAVKED PLSFKSKKTK AVAKSGGAVY
160 170 180 190 200
QWKIMQSLGI SDEEIPMFAD SAYWLNYFPP HCESDLKLLG VGVDWRRSFI
210 220 230 240 250
TTDVNGYYDS FVRWQFESLK ALGKVKYGKR YSIWSTIDDQ QCADHERAQG
260 270 280 290 300
EGVGPQNYTL IKLEVVEPIP ECLKEIHSQG KKIYLVPGTL RPETMYGQTN
310 320 330 340 350
CWILPTGKYG AFEMANGDIF VCTERSARNM SYQQMTTGKG EYKCLAKFEG
360 370 380 390 400
SDILGAALKA PLAINPIVYV LPMLTIDENK GTGVVTSVPS DSPDDYASLQ
410 420 430 440 450
DLKAKAPLRA KFSIKDEWVL PFEVVPIIDI PGYSNESAVR AYKDLGIKSQ
460 470 480 490 500
NDRALLDQAK DLCYQKGFND GVMSVGPYAG RKVSEVKKII KDEMVASGQA
510 520 530 540 550
VDYSEPTSKV VSRSGDECVV ALSDQWYINY GDDDIEWKNQ TIKQLESMEF
560 570 580 590 600
YSAETKKKFE IALGWMNQWA CSRSFGLGTH LPWDEKFLIE SLSDSTIYMA
610 620 630 640 650
FYTVAHLLQG DVNGSKPGSA GITPKQMTSA CWDYVLMGKP YPEGCEVSEE
660 670 680 690 700
KLKELKKEFT YWYPVDIRVS GADLIQNHLT FFLYTHAAIF EKKFQPKSIR
710 720 730 740 750
ANGFVNLNGE KMSKSTGNFL TLVDSVAKFS ADGTRVALAD AGDSIEDANF
760 770 780 790 800
VDQTAVTSLL KLHTQIQWVQ ETLDSIDKFR SGPLDRIQDT IFESEINNII
810 820 830 840 850
VESEKAYQKT NFRDALHLVF FDLQNARDHY KVTTLDQMHK DLVLRFIEVQ
860 870 880 890 900
ALLIYPIAPH FAQKLFNMLG KGNILSAGWP KAGAIDYEAL KKNNYVQQTI
910 920 930 940 950
YNFRMKLQVY QKAKLKGKPA GTKAIPDQST IIVSKSYPKW QQDVLEYLAT
960 970 980 990 1000
IYNEDSKSFT KDNNAIAEEL LSREEMKPHK KNLMGFVASA IQNVKESGKD
1010 1020 1030 1040 1050
ALQTSLSFDE TSTLTDNIDY ICKTLELTSF DVKDFNEIPQ ASQSKIQPIP

GKPQFQFV
Length:1,058
Mass (Da):119,529
Last modified:May 24, 2005 - v1
Checksum:i62D8D2139322198E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA Translation: EAL64563.1
RefSeqiXP_638060.1, XM_632968.1

Genome annotation databases

EnsemblProtistsiEAL64563; EAL64563; DDB_G0285451
GeneIDi8625106
KEGGiddi:DDB_G0285451

Similar proteinsi

Entry informationi

Entry nameiSYLC_DICDI
AccessioniPrimary (citable) accession number: Q54N83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families

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