Q54N73 (7TMK1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Seven transmembrane domain-containing tyrosine-protein kinase 1
EC=2.7.10.1

Gene names

Name:	7tmk1
ORF Names:	DDB_G0285463

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 691	691	Seven transmembrane domain-containing tyrosine-protein kinase 1		PRO_0000355144
Regions
	Topological domain	1 – 33	33	Extracellular Potential
	Transmembrane	34 – 54	21	Helical; Name=1; Potential
	Topological domain	55 – 126	72	Cytoplasmic Potential
	Transmembrane	127 – 144	18	Helical; Name=2; Potential
	Topological domain	145 – 153	9	Extracellular Potential
	Transmembrane	154 – 176	23	Helical; Name=3; Potential
	Topological domain	177 – 186	10	Cytoplasmic Potential
	Transmembrane	187 – 207	21	Helical; Name=4; Potential
	Topological domain	208 – 227	20	Extracellular Potential
	Transmembrane	228 – 248	21	Helical; Name=5; Potential
	Topological domain	249 – 258	10	Cytoplasmic Potential
	Transmembrane	259 – 279	21	Helical; Name=6; Potential
	Topological domain	280 – 284	5	Extracellular Potential
	Transmembrane	285 – 305	21	Helical; Name=7; Potential
	Topological domain	306 – 691	386	Cytoplasmic Potential
	Domain	363 – 634	272	Protein kinase
	Nucleotide binding	369 – 377	9	ATP By similarity
	Compositional bias	68 – 77	10	Poly-Asn
	Compositional bias	647 – 654	8	Poly-Asn
Sites
	Active site	493	1	Proton acceptor By similarity
	Binding site	390	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54N73 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 9F6ED2E94AAA1706	FASTA	691	77,496
	10 20 30 40 50 60 MDTSCVSINQ CGFCTYLFNR SIPLAGEGDG AIMFNTMVDS MALGYIFSAL YLLFRLQRSY 70 80 90 100 110 120 TYLQKSSNNN NGNGNGNGSS NNDIISINSS NGLNRSGVKI SQDTLWDKNF GISIDHPRII 130 140 150 160 170 180 NSTYFKYTLF VSLWLAFEGL LLLFLPPNSL AYPAFVIIVG TGHIVTDNWV LVFLYGKEDD 190 200 210 220 230 240 RFSARRSFYS CTLLYLIICC TTLASFFDDQ TMCKKNDCQT FMFQDEYTSL AITVASLVVY 250 260 270 280 290 300 TIVLGMTIKR SFLRPTGRIW LLFLMGYNCI SSVGALLNIL DVDAGYCFLG IAAIIYSFSY 310 320 330 340 350 360 GPLLFRTCGN DTNLLRARGE FLPLLTNFQE YTSLFGRESI STSGEGATTA LQLSAFYIRF 370 380 390 400 410 420 NEFKFGQVIG EGYFGEVRKA VWKGAVVAVK ILHRNSFRNT DGNKEENVFL KEVAILSILR 430 440 450 460 470 480 HPNVLQFLGV CSETNLNGIV TEYMGGGSLD RLLTDRYFLI KQNPILAWNM AISIARGMFY 490 500 510 520 530 540 LHDWKPNPIL HRDLSTKNIL LDESLTIAKV ADFGLSKEQG FEMTSTVGHL CYQAPEVFIG 550 560 570 580 590 600 ELYTPKADVY SFGLLVWCII TGEQPNQNLQ PLKMAHLAAY ENYRPPMPQP MDPMWENLGK 610 620 630 640 650 660 LIEMCWKKSP EERPSFSFIL DFLEANVPIS NTYVPPLKCI SDNSVSNNFN NNNNTLNNGS 670 680 690 TNNLGLLTLS FSTLNLQKQG GGAEEFHYID G

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000079 Genomic DNA. Translation: EAL64569.1.
RefSeq	XP_638070.1. XM_632978.1.
3D structure databases
HSSP	HSSP built from PDB template 1UWJ based on UniProtKB P15056.
ProteinModelPortal	Q54N73.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0229939; DDB0229939; DDB_G0285463.
GeneID	8625116.
GenomeReviews	Gene locus 7tmk1 in contig CM000153_GR.
KEGG	ddi:DDB_G0285463.
Organism-specific databases
dictyBase	DDB_G0285463.
Phylogenomic databases
eggNOG	KOG0192.
GeneTree	EPrGT00050000000319.
PhylomeDB	Q54N73.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

7TMK1_DICDI

Accession

Primary (citable) accession number: Q54N73

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)