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Q54N73 (7TMK1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Seven transmembrane domain-containing tyrosine-protein kinase 1

EC=2.7.10.1
Gene names
Name:7tmk1
ORF Names:DDB_G0285463
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length691 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Tyr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 691691Seven transmembrane domain-containing tyrosine-protein kinase 1
PRO_0000355144

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 5421Helical; Name=1; Potential
Topological domain55 – 12672Cytoplasmic Potential
Transmembrane127 – 14418Helical; Name=2; Potential
Topological domain145 – 1539Extracellular Potential
Transmembrane154 – 17623Helical; Name=3; Potential
Topological domain177 – 18610Cytoplasmic Potential
Transmembrane187 – 20721Helical; Name=4; Potential
Topological domain208 – 22720Extracellular Potential
Transmembrane228 – 24821Helical; Name=5; Potential
Topological domain249 – 25810Cytoplasmic Potential
Transmembrane259 – 27921Helical; Name=6; Potential
Topological domain280 – 2845Extracellular Potential
Transmembrane285 – 30521Helical; Name=7; Potential
Topological domain306 – 691386Cytoplasmic Potential
Domain363 – 634272Protein kinase
Nucleotide binding369 – 3779ATP By similarity
Compositional bias68 – 7710Poly-Asn
Compositional bias647 – 6548Poly-Asn

Sites

Active site4931Proton acceptor By similarity
Binding site3901ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54N73 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 9F6ED2E94AAA1706

FASTA69177,496
        10         20         30         40         50         60 
MDTSCVSINQ CGFCTYLFNR SIPLAGEGDG AIMFNTMVDS MALGYIFSAL YLLFRLQRSY 

        70         80         90        100        110        120 
TYLQKSSNNN NGNGNGNGSS NNDIISINSS NGLNRSGVKI SQDTLWDKNF GISIDHPRII 

       130        140        150        160        170        180 
NSTYFKYTLF VSLWLAFEGL LLLFLPPNSL AYPAFVIIVG TGHIVTDNWV LVFLYGKEDD 

       190        200        210        220        230        240 
RFSARRSFYS CTLLYLIICC TTLASFFDDQ TMCKKNDCQT FMFQDEYTSL AITVASLVVY 

       250        260        270        280        290        300 
TIVLGMTIKR SFLRPTGRIW LLFLMGYNCI SSVGALLNIL DVDAGYCFLG IAAIIYSFSY 

       310        320        330        340        350        360 
GPLLFRTCGN DTNLLRARGE FLPLLTNFQE YTSLFGRESI STSGEGATTA LQLSAFYIRF 

       370        380        390        400        410        420 
NEFKFGQVIG EGYFGEVRKA VWKGAVVAVK ILHRNSFRNT DGNKEENVFL KEVAILSILR 

       430        440        450        460        470        480 
HPNVLQFLGV CSETNLNGIV TEYMGGGSLD RLLTDRYFLI KQNPILAWNM AISIARGMFY 

       490        500        510        520        530        540 
LHDWKPNPIL HRDLSTKNIL LDESLTIAKV ADFGLSKEQG FEMTSTVGHL CYQAPEVFIG 

       550        560        570        580        590        600 
ELYTPKADVY SFGLLVWCII TGEQPNQNLQ PLKMAHLAAY ENYRPPMPQP MDPMWENLGK 

       610        620        630        640        650        660 
LIEMCWKKSP EERPSFSFIL DFLEANVPIS NTYVPPLKCI SDNSVSNNFN NNNNTLNNGS 

       670        680        690 
TNNLGLLTLS FSTLNLQKQG GGAEEFHYID G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000079 Genomic DNA. Translation: EAL64569.1.
RefSeqXP_638070.1. XM_632978.1.

3D structure databases

HSSPHSSP built from PDB template 1UWJ based on UniProtKB P15056.
ProteinModelPortalQ54N73.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0229939; DDB0229939; DDB_G0285463.
GeneID8625116.
GenomeReviewsGene locus 7tmk1 in contig CM000153_GR.
KEGGddi:DDB_G0285463.

Organism-specific databases

dictyBaseDDB_G0285463.

Phylogenomic databases

eggNOGKOG0192.
GeneTreeEPrGT00050000000319.
PhylomeDBQ54N73.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name7TMK1_DICDI
AccessionPrimary (citable) accession number: Q54N73
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 24, 2005
Last modified: September 21, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families