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Q54N38 (UCHL5_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase isozyme L5

Short name=UCH-L5
EC=3.4.19.12
Alternative name(s):
Ubiquitin thioesterase L5
Gene names
Name:uch2
Synonyms:uchl5
ORF Names:DDB_G0285527
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the 19S (PA700) regulatory complex of the 26S proteasome By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C12 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Ubiquitin carboxyl-terminal hydrolase isozyme L5
PRO_0000331127

Sites

Active site831Nucleophile By similarity
Active site1571Proton donor By similarity
Site1721Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54N38 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: CAE23E5DB3EBE169

FASTA34339,325
        10         20         30         40         50         60 
MSENEGWCTI ESDPGVFTEL ITKIGVKDIQ VEELYTLDSS EYDRLKPVLG LIFLFKWEKE 

        70         80         90        100        110        120 
EENRTISDNE NIFFANQVIQ NACATQAILS VLLNSEGIEL GEELSNFKSF VGDFPPMMKG 

       130        140        150        160        170        180 
EAIGNSELIK ETHNSFTVQD PFIFSKKKNR KPSDAFHFIS FIPFQGKVYE LDGLKKGPYC 

       190        200        210        220        230        240 
LGDCTPDNWL EIATPFIQKR MEKYSQGEIR FNLMAVIKNR QTTLQEKILT LEKKKNDLEI 

       250        260        270        280        290        300 
KLSELNSGSG GDNKEESGGA TPTTKEDLNF MINVVNNDIE EANNEILMEQ EKFRNWKDEN 

       310        320        330        340 
IRRKHNFTPL ILNLIKGLAE KDNLQPLIQK AKDQISQKQQ QHK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000079 Genomic DNA. Translation: EAL64601.1.

3D structure databases

ProteinModelPortalQ54N38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0233072.

Protein family/group databases

MEROPSC12.005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0233072; DDB0233072; DDB_G0285527.
KEGGddi:DDB_G0285527.

Organism-specific databases

dictyBaseDDB_G0285527. uch2.

Phylogenomic databases

eggNOGNOG321645.
KOK05610.
OMADEDAFHF.
PhylomeDBQ54N38.
ProtClustDBCLSZ2430176.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
IPR017390. Ubiquitinyl_hydrolase_UCH37.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PIRSFPIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Other

PROQ54N38.

Entry information

Entry nameUCHL5_DICDI
AccessionPrimary (citable) accession number: Q54N38
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase