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Protein

Mitochondrial substrate carrier family protein B

Gene

mcfB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi53 – 64121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi90 – 101122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein B
Gene namesi
Name:mcfB
ORF Names:DDB_G0285599
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285599. mcfB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 141141Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei142 – 15918Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini160 – 20344Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei204 – 22421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini225 – 24420Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei245 – 26521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini266 – 29328Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei294 – 31421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini315 – 33824Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei339 – 35921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini360 – 40243Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei403 – 42321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini424 – 43411Mitochondrial intermembraneBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Mitochondrial substrate carrier family protein BPRO_0000385518Add
BLAST

Proteomic databases

PaxDbiQ54MZ4.
PRIDEiQ54MZ4.

Structurei

3D structure databases

ProteinModelPortaliQ54MZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 7536EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini77 – 11236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Repeati136 – 22994Solcar 1Add
BLAST
Repeati239 – 32587Solcar 2Add
BLAST
Repeati333 – 42290Solcar 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 2826Poly-AsnAdd
BLAST
Compositional biasi31 – 355Poly-Asn

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
InParanoidiQ54MZ4.
KOiK14684.
OMAiYSAIQFL.
PhylomeDBiQ54MZ4.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54MZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNNNNNNN NNNNNNNNNN NNNNNNNNDK NNNNNIDSSI KEKKLKEWFD
60 70 80 90 100
KFDVDKDGSL DSNELKKGFK LHANIDMKDE QITKMMERAD SNKNHRIEWD
110 120 130 140 150
EFLKVASDSS SPEIEDIAEH WLQYSTKPIV HAPADVPSWK LLLSGGVAGA
160 170 180 190 200
VSRTCTSPLE RLKILNQVGH MNLEQNAPKY KGRGIIQSLK TMYTTEGFIG
210 220 230 240 250
FFKGNGTNVI RIAPYSAIQF LSYEKYKNFL LNNNDQTHLT TYENLFVGGA
260 270 280 290 300
AGVTSLLCTY PLDLIRSRLT VQVFGNKYNG IADTCKMIIR EEGVAGLYKG
310 320 330 340 350
LFASALGVAP YVAINFTTYE NLKKTFIPKD TTPTVVQSLT FGAISGATAQ
360 370 380 390 400
TLTYPIDLIR RRLQVQGIGG KDILYNGTFD AFRKIIRDEG VLGLYNGMIP
410 420 430
CYLKVIPAIS ISFCVYEVMK KILKIDSKKI SYQS
Length:434
Mass (Da):48,684
Last modified:May 24, 2005 - v1
Checksum:i40E6C46F905314A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA. Translation: EAL64637.1.
RefSeqiXP_638149.1. XM_633057.1.

Genome annotation databases

EnsemblProtistsiDDB0237602; DDB0237602; DDB_G0285599.
GeneIDi8625197.
KEGGiddi:DDB_G0285599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA. Translation: EAL64637.1.
RefSeqiXP_638149.1. XM_633057.1.

3D structure databases

ProteinModelPortaliQ54MZ4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ54MZ4.
PRIDEiQ54MZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0237602; DDB0237602; DDB_G0285599.
GeneIDi8625197.
KEGGiddi:DDB_G0285599.

Organism-specific databases

dictyBaseiDDB_G0285599. mcfB.

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
InParanoidiQ54MZ4.
KOiK14684.
OMAiYSAIQFL.
PhylomeDBiQ54MZ4.

Miscellaneous databases

PROiQ54MZ4.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Mitochondrial carrier family: repertoire and peculiarities of the cellular slime mould Dictyostelium discoideum."
    Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G., Klein G.
    Biochimie 89:1058-1069(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiMCFB_DICDI
AccessioniPrimary (citable) accession number: Q54MZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 24, 2005
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.