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Q54MV6 (BGAL2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase 2

Short name=Lactase 2
EC=3.2.1.23
Gene names
Name:glb2
ORF Names:DDB_G0285637
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length761 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 761738Probable beta-galactosidase 2
PRO_0000328063

Regions

Compositional bias27 – 359Poly-Asn
Compositional bias466 – 4749Poly-Gly
Compositional bias623 – 6308Poly-Ser
Compositional bias739 – 7424Poly-Ile

Sites

Active site1951Proton donor Potential
Active site2671Nucleophile Potential

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation3851N-linked (GlcNAc...) Potential
Glycosylation4051N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation5011N-linked (GlcNAc...) Potential
Glycosylation5521N-linked (GlcNAc...) Potential
Glycosylation5531N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Potential
Glycosylation5921N-linked (GlcNAc...) Potential
Glycosylation6421N-linked (GlcNAc...) Potential
Glycosylation6901N-linked (GlcNAc...) Potential
Glycosylation6961N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q54MV6 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 5220AD3C8EFB7627

FASTA76187,415
        10         20         30         40         50         60 
MGTIKNNFQL LWLILLIVVL VNGKSINKNN NNNKNEIINV TYDGRSLIIN GERKLLFSGS 

        70         80         90        100        110        120 
IHYPRTSEEM WPIILKQSKD AGIDIIDTYI FWNIHQPNSP SEYYFDGNAN ITKFLDLCKE 

       130        140        150        160        170        180 
FDLYVNLRIG PYVCAEWTYG GFPIWLKEIP NIVYRDYNQQ WMNEMSIWME FVVKYLDNYF 

       190        200        210        220        230        240 
APNGGPIILA QVENEYGWLE QEYGINGTEY AKWSIDFAKS LNIGIPWIMC QQNDIESAIN 

       250        260        270        280        290        300 
TCNGYYCHDW ISSHWEQFPN QPSFWTENWI GWFENWGQAK PKRPVQDILY SNARFIAYGG 

       310        320        330        340        350        360 
SLINYYMWFG GTNFGRTSGG PWIITSYDYD APLDEFGQPN EPKFSLSSKF HQVLHAIESD 

       370        380        390        400        410        420 
LLNNQPPKSP TFLSQFIEVH QYGINLSFIT NYGTSTTPKI IQWMNQTYTI QPWSVLIIYN 

       430        440        450        460        470        480 
NEILFDTSFI PPNTLFNNNT INNFKPINQN IIQSIFQISD FNLNSGGGGG DGDGNSVNSV 

       490        500        510        520        530        540 
SPIEQLLITK DTSDYCWYST NVTTTSLSYN EKGNIFLTIT EFYDYVHIFI DNEYQGSAFS 

       550        560        570        580        590        600 
PSLCQLQLNP INNSTTFQLQ ILSMTIGLEN YASHMENYTR GILGSILIGS QNLTNNQWLM 

       610        620        630        640        650        660 
KSGLIGENIK IFNNDNTINW QTSPSSSSSS LIQKPLTWYK LNISLVGLPI DISSTVYALD 

       670        680        690        700        710        720 
MSSMNKGMIW VNGYSIGRYW LIEATQSICN QSAIENYSYI GEYDPSNYRI DCNKPSQSIY 

       730        740        750        760 
SVPIDWLFNN NYNNQYATII IIEELNGNPN EIQLLSNKII N 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000079 Genomic DNA. Translation: EAL64656.1.
RefSeqXP_638187.1. XM_633095.1.

3D structure databases

ProteinModelPortalQ54MV6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0186630.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0266381; DDB0266381; DDB_G0285637.
GeneID8625233.
KEGGddi:DDB_G0285637.

Organism-specific databases

dictyBaseDDB_G0285637. glb2.

Phylogenomic databases

eggNOGCOG1874.
OMANQGTHYE.
PhylomeDBQ54MV6.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGAL2_DICDI
AccessionPrimary (citable) accession number: Q54MV6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase