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Protein

Probable beta-galactosidase 2

Gene

glb2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei195Proton donorSequence analysis1
Active sitei267NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase 2 (EC:3.2.1.23)
Short name:
Lactase 2
Gene namesi
Name:glb2
ORF Names:DDB_G0285637
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285637. glb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000032806324 – 761Probable beta-galactosidase 2Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1
Glycosylationi405N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi501N-linked (GlcNAc...)Sequence analysis1
Glycosylationi552N-linked (GlcNAc...)Sequence analysis1
Glycosylationi553N-linked (GlcNAc...)Sequence analysis1
Glycosylationi577N-linked (GlcNAc...)Sequence analysis1
Glycosylationi592N-linked (GlcNAc...)Sequence analysis1
Glycosylationi642N-linked (GlcNAc...)Sequence analysis1
Glycosylationi690N-linked (GlcNAc...)Sequence analysis1
Glycosylationi696N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ54MV6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0266381.

Structurei

3D structure databases

ProteinModelPortaliQ54MV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 35Poly-Asn9
Compositional biasi466 – 474Poly-Gly9
Compositional biasi623 – 630Poly-Ser8
Compositional biasi739 – 742Poly-Ile4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
InParanoidiQ54MV6.
OMAiINITRDV.
PhylomeDBiQ54MV6.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54MV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTIKNNFQL LWLILLIVVL VNGKSINKNN NNNKNEIINV TYDGRSLIIN
60 70 80 90 100
GERKLLFSGS IHYPRTSEEM WPIILKQSKD AGIDIIDTYI FWNIHQPNSP
110 120 130 140 150
SEYYFDGNAN ITKFLDLCKE FDLYVNLRIG PYVCAEWTYG GFPIWLKEIP
160 170 180 190 200
NIVYRDYNQQ WMNEMSIWME FVVKYLDNYF APNGGPIILA QVENEYGWLE
210 220 230 240 250
QEYGINGTEY AKWSIDFAKS LNIGIPWIMC QQNDIESAIN TCNGYYCHDW
260 270 280 290 300
ISSHWEQFPN QPSFWTENWI GWFENWGQAK PKRPVQDILY SNARFIAYGG
310 320 330 340 350
SLINYYMWFG GTNFGRTSGG PWIITSYDYD APLDEFGQPN EPKFSLSSKF
360 370 380 390 400
HQVLHAIESD LLNNQPPKSP TFLSQFIEVH QYGINLSFIT NYGTSTTPKI
410 420 430 440 450
IQWMNQTYTI QPWSVLIIYN NEILFDTSFI PPNTLFNNNT INNFKPINQN
460 470 480 490 500
IIQSIFQISD FNLNSGGGGG DGDGNSVNSV SPIEQLLITK DTSDYCWYST
510 520 530 540 550
NVTTTSLSYN EKGNIFLTIT EFYDYVHIFI DNEYQGSAFS PSLCQLQLNP
560 570 580 590 600
INNSTTFQLQ ILSMTIGLEN YASHMENYTR GILGSILIGS QNLTNNQWLM
610 620 630 640 650
KSGLIGENIK IFNNDNTINW QTSPSSSSSS LIQKPLTWYK LNISLVGLPI
660 670 680 690 700
DISSTVYALD MSSMNKGMIW VNGYSIGRYW LIEATQSICN QSAIENYSYI
710 720 730 740 750
GEYDPSNYRI DCNKPSQSIY SVPIDWLFNN NYNNQYATII IIEELNGNPN
760
EIQLLSNKII N
Length:761
Mass (Da):87,415
Last modified:May 24, 2005 - v1
Checksum:i5220AD3C8EFB7627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA. Translation: EAL64656.1.
RefSeqiXP_638187.1. XM_633095.1.

Genome annotation databases

EnsemblProtistsiEAL64656; EAL64656; DDB_G0285637.
GeneIDi8625233.
KEGGiddi:DDB_G0285637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000079 Genomic DNA. Translation: EAL64656.1.
RefSeqiXP_638187.1. XM_633095.1.

3D structure databases

ProteinModelPortaliQ54MV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0266381.

Proteomic databases

PaxDbiQ54MV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL64656; EAL64656; DDB_G0285637.
GeneIDi8625233.
KEGGiddi:DDB_G0285637.

Organism-specific databases

dictyBaseiDDB_G0285637. glb2.

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
InParanoidiQ54MV6.
OMAiINITRDV.
PhylomeDBiQ54MV6.

Miscellaneous databases

PROiQ54MV6.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGAL2_DICDI
AccessioniPrimary (citable) accession number: Q54MV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.