Probable beta-galactosidase 2 precursor - Dictyostelium discoideum (Slime mold)

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Reviewed, UniProtKB/Swiss-Prot Q54MV6 (BGAL2_DICDI)

Last modified February 9, 2010. Version 38. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Probable beta-galactosidase 2
      Short name=Lactase 2
    EC=3.2.1.23

Gene names

Name:	glb2
ORF Names:	DDB_G0285637

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	761 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.
Sequence similarities	Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	beta-galactosidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

23

Potential

Chain

738

Probable beta-galactosidase 2

PRO_0000328063

Regions

Compositional bias

9

Poly-Asn

Compositional bias

9

Poly-Gly

Compositional bias

8

Poly-Ser

Compositional bias

4

Poly-Ile

Sites

Active site

1

Proton donor Potential

Active site

1

Nucleophile Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q54MV6-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 5220AD3C8EFB7627
Show »

761

87,415

        10         20         30         40         50         60 
MGTIKNNFQL LWLILLIVVL VNGKSINKNN NNNKNEIINV TYDGRSLIIN GERKLLFSGS 

        70         80         90        100        110        120 
IHYPRTSEEM WPIILKQSKD AGIDIIDTYI FWNIHQPNSP SEYYFDGNAN ITKFLDLCKE 

       130        140        150        160        170        180 
FDLYVNLRIG PYVCAEWTYG GFPIWLKEIP NIVYRDYNQQ WMNEMSIWME FVVKYLDNYF 

       190        200        210        220        230        240 
APNGGPIILA QVENEYGWLE QEYGINGTEY AKWSIDFAKS LNIGIPWIMC QQNDIESAIN 

       250        260        270        280        290        300 
TCNGYYCHDW ISSHWEQFPN QPSFWTENWI GWFENWGQAK PKRPVQDILY SNARFIAYGG 

       310        320        330        340        350        360 
SLINYYMWFG GTNFGRTSGG PWIITSYDYD APLDEFGQPN EPKFSLSSKF HQVLHAIESD 

       370        380        390        400        410        420 
LLNNQPPKSP TFLSQFIEVH QYGINLSFIT NYGTSTTPKI IQWMNQTYTI QPWSVLIIYN 

       430        440        450        460        470        480 
NEILFDTSFI PPNTLFNNNT INNFKPINQN IIQSIFQISD FNLNSGGGGG DGDGNSVNSV 

       490        500        510        520        530        540 
SPIEQLLITK DTSDYCWYST NVTTTSLSYN EKGNIFLTIT EFYDYVHIFI DNEYQGSAFS 

       550        560        570        580        590        600 
PSLCQLQLNP INNSTTFQLQ ILSMTIGLEN YASHMENYTR GILGSILIGS QNLTNNQWLM 

       610        620        630        640        650        660 
KSGLIGENIK IFNNDNTINW QTSPSSSSSS LIQKPLTWYK LNISLVGLPI DISSTVYALD 

       670        680        690        700        710        720 
MSSMNKGMIW VNGYSIGRYW LIEATQSICN QSAIENYSYI GEYDPSNYRI DCNKPSQSIY 

       730        740        750        760 
SVPIDWLFNN NYNNQYATII IIEELNGNPN EIQLLSNKII N

References

[1]

"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.

expand/collapse author list

Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000079 Genomic DNA. Translation: EAL64656.1.
RefSeq	XP_638187.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	8625233.
KEGG	ddi:DDBDRAFT_0186630.
Organism-specific databases
dictyBase	DDB_G0285637. glb2.
Phylogenomic databases
eggNOG	KOG0496.
HOGENOM	HBG318019.
OMA	LNEGRRD.
PhylomeDB	Q54MV6.
Enzyme and pathway databases
BRENDA	3.2.1.23. 424.
Family and domain databases
InterPro	IPR019801. Glyco_hydro_35_CS. IPR017853. Glyco_hydro_catalytic_core. IPR013781. Glyco_hydro_sg_catalytic. IPR001944. Glycoside_Hdrlase_35. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PANTHER	PTHR23421. Glyco_hydro_35. 1 hit.
Pfam	PF01301. Glyco_hydro_35. 1 hit. [Graphical view]
PRINTS	PR00742. GLHYDRLASE35.
PROSITE	PS01182. GLYCOSYL_HYDROL_F35. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BGAL2_DICDI

Accession

Primary (citable) accession number: Q54MV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents