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Q54MV6

- BGAL2_DICDI

UniProt

Q54MV6 - BGAL2_DICDI

Protein

Probable beta-galactosidase 2

Gene

glb2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei195 – 1951Proton donorSequence Analysis
    Active sitei267 – 2671NucleophileSequence Analysis

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-galactosidase 2 (EC:3.2.1.23)
    Short name:
    Lactase 2
    Gene namesi
    Name:glb2
    ORF Names:DDB_G0285637
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0285637. glb2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 761738Probable beta-galactosidase 2PRO_0000328063Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi552 – 5521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi577 – 5771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi642 – 6421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0186630.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54MV6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 359Poly-Asn
    Compositional biasi466 – 4749Poly-Gly
    Compositional biasi623 – 6308Poly-Ser
    Compositional biasi739 – 7424Poly-Ile

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1874.
    OMAiNQGTHYE.
    PhylomeDBiQ54MV6.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PRINTSiPR00742. GLHYDRLASE35.
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54MV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTIKNNFQL LWLILLIVVL VNGKSINKNN NNNKNEIINV TYDGRSLIIN    50
    GERKLLFSGS IHYPRTSEEM WPIILKQSKD AGIDIIDTYI FWNIHQPNSP 100
    SEYYFDGNAN ITKFLDLCKE FDLYVNLRIG PYVCAEWTYG GFPIWLKEIP 150
    NIVYRDYNQQ WMNEMSIWME FVVKYLDNYF APNGGPIILA QVENEYGWLE 200
    QEYGINGTEY AKWSIDFAKS LNIGIPWIMC QQNDIESAIN TCNGYYCHDW 250
    ISSHWEQFPN QPSFWTENWI GWFENWGQAK PKRPVQDILY SNARFIAYGG 300
    SLINYYMWFG GTNFGRTSGG PWIITSYDYD APLDEFGQPN EPKFSLSSKF 350
    HQVLHAIESD LLNNQPPKSP TFLSQFIEVH QYGINLSFIT NYGTSTTPKI 400
    IQWMNQTYTI QPWSVLIIYN NEILFDTSFI PPNTLFNNNT INNFKPINQN 450
    IIQSIFQISD FNLNSGGGGG DGDGNSVNSV SPIEQLLITK DTSDYCWYST 500
    NVTTTSLSYN EKGNIFLTIT EFYDYVHIFI DNEYQGSAFS PSLCQLQLNP 550
    INNSTTFQLQ ILSMTIGLEN YASHMENYTR GILGSILIGS QNLTNNQWLM 600
    KSGLIGENIK IFNNDNTINW QTSPSSSSSS LIQKPLTWYK LNISLVGLPI 650
    DISSTVYALD MSSMNKGMIW VNGYSIGRYW LIEATQSICN QSAIENYSYI 700
    GEYDPSNYRI DCNKPSQSIY SVPIDWLFNN NYNNQYATII IIEELNGNPN 750
    EIQLLSNKII N 761
    Length:761
    Mass (Da):87,415
    Last modified:May 24, 2005 - v1
    Checksum:i5220AD3C8EFB7627
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000079 Genomic DNA. Translation: EAL64656.1.
    RefSeqiXP_638187.1. XM_633095.1.

    Genome annotation databases

    EnsemblProtistsiDDB0266381; DDB0266381; DDB_G0285637.
    GeneIDi8625233.
    KEGGiddi:DDB_G0285637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000079 Genomic DNA. Translation: EAL64656.1 .
    RefSeqi XP_638187.1. XM_633095.1.

    3D structure databases

    ProteinModelPortali Q54MV6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0186630.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0266381 ; DDB0266381 ; DDB_G0285637 .
    GeneIDi 8625233.
    KEGGi ddi:DDB_G0285637.

    Organism-specific databases

    dictyBasei DDB_G0285637. glb2.

    Phylogenomic databases

    eggNOGi COG1874.
    OMAi NQGTHYE.
    PhylomeDBi Q54MV6.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PRINTSi PR00742. GLHYDRLASE35.
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiBGAL2_DICDI
    AccessioniPrimary (citable) accession number: Q54MV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3