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Protein

Probable alanine aminotransferase, mitochondrial

Gene

gpt

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pathwayi: L-alanine degradation via transaminase pathway

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable alanine aminotransferase, mitochondrial (gpt)
This subpathway is part of the pathway L-alanine degradation via transaminase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from L-alanine, the pathway L-alanine degradation via transaminase pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-70614 Amino acid synthesis and interconversion (transamination)
UniPathwayiUPA00528; UER00586

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alanine aminotransferase, mitochondrial (EC:2.6.1.2)
Short name:
ALT
Alternative name(s):
Glutamate pyruvate transaminase
Short name:
GPT
Glutamic--alanine transaminase
Glutamic--pyruvic transaminase
Gene namesi
Name:gpt
ORF Names:DDB_G0285899
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285899

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000032838419 – 534Probable alanine aminotransferase, mitochondrialAdd BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei352N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ54MJ7

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232139

Structurei

3D structure databases

ProteinModelPortaliQ54MJ7
SMRiQ54MJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 35Poly-Thr5
Compositional biasi38 – 41Poly-Asn4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0258 Eukaryota
COG0436 LUCA
InParanoidiQ54MJ7
KOiK00814
OMAiAPGTEWV
PhylomeDBiQ54MJ7

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54MJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRSLKVLL SNPPINRVKP SSTIIQPLSN TTTTTIINNN NITNFEKMTH
60 70 80 90 100
KKSMTIDNIC QNVRNAQYAV RGELVIRAEA ISHQLQKQKT EGTKTLPFEE
110 120 130 140 150
IVYCNIGNPQ QLKQKPLTYF RQVVSLVECP DLLDNPYVEK IYPADVISRA
160 170 180 190 200
KEILGSINNT TGAYSNSQGI GLVLRSVADF IERRDGHKSD PSEIFLTDGA
210 220 230 240 250
SVGVQRILKL LIKDRSDGIL IPIPQYPLYS ATIELYNGSQ LGYLLNEEKG
260 270 280 290 300
WSLEISQLEH SYNDAVSKGI NPRALVIINP GNPTGQCLDR ANMEEIVKFC
310 320 330 340 350
LEKNVVLLAD EVYQENVYVK ESKPFISFKK VVKDMGGDYA DLEMVSFHSV
360 370 380 390 400
SKGFVGECGK RGGYMELNGV TQDVKAEIYK LASIGLCPNV IGQLVVDLMV
410 420 430 440 450
RPPVAGEQSH DLYLKERDNI YESLKKRANL LTNALNNLEG VTCNPSEGAM
460 470 480 490 500
YAFPQIRLPA KAVEYANSIG KAPDAYYCIQ LLEATGICVV PGSGFGQKDG
510 520 530
TWHFRTTFLP SEEAIEGVCK RIADFHQSFM NKYK
Length:534
Mass (Da):59,495
Last modified:May 24, 2005 - v1
Checksum:i3C75A9FA6ACDA4C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000082 Genomic DNA Translation: EAL64484.1
RefSeqiXP_637993.1, XM_632901.1

Genome annotation databases

EnsemblProtistsiEAL64484; EAL64484; DDB_G0285899
GeneIDi8625344
KEGGiddi:DDB_G0285899

Similar proteinsi

Entry informationi

Entry nameiALAM_DICDI
AccessioniPrimary (citable) accession number: Q54MJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health