Q54MH8 (DLPB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynamin-like protein B
EC=3.6.5.5

Gene names

Name:	dlpB
ORF Names:	DDB_G0285931

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	808 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in cytokinesis. May hydrolyze GTP. Ref.2
Catalytic activity	GTP + H2O = GDP + phosphate.
Subcellular location	Cytoplasm Potential.
Developmental stage	Expression begins during cell cycle progression, between 12 and 24 hours after germination. Reach a maximum around mid-log phase and disappear during the stationary phase. Ref.2
Disruption phenotype	Produced cells are larger and a large amount of them contains more than 2 nuclei. Ref.2
Sequence similarities	Belongs to the dynamin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from mutant phenotype Ref.2. Source: dictyBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 808	808	Dynamin-like protein B		PRO_0000371338
Regions
	Nucleotide binding	53 – 60	8	GTP Potential
	Nucleotide binding	150 – 154	5	GTP Potential
	Nucleotide binding	239 – 242	4	GTP Potential
	Compositional bias	536 – 593	58	Ser-rich
	Compositional bias	667 – 670	4	Poly-Asn
	Compositional bias	677 – 694	18	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q54MH8 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 4F0410125AA5ED09	FASTA	808	92,714
	10 20 30 40 50 60 MDRQSVVKST AIPFPLNFDN EKYDDMYKAY NKIMVLARDL NAFIETPEFV FIGKDGNGKS 70 80 90 100 110 120 ALIESFIGFP MMIGEGSSLR PLHITLMNNA RCEEPIVTFK RDRSLDSYEF DRQIELSMVS 130 140 150 160 170 180 SEISKRNQKT SIPIEITIEY RYYLNMLLIE PPSVSIQPTN AITIQGQSMT SPANQLANKI 190 200 210 220 230 240 AKLSIGNEMG EMITQYTKSN NRTLVFVETS TNGGTNSSEM LELAKKLDYK LDRSIFVFNK 250 260 270 280 290 300 FHSLLTGDQP FTNGRDANRF LGSPSIGAPT FFTTLPSTAQ RSQCNSKDQL SQLCDQLQQT 310 320 330 340 350 360 DLNILEQLQF DKKYERNVGL SAFRHWISEF TWRKYLDSVP EVLKRLNSFR TTSEDQLYQI 370 380 390 400 410 420 RQQLERTNAV TLRQIANSYV SIEFIQCIEK LVTRTLEGNP SLNGQTLEEE KSQDETGDWY 430 440 450 460 470 480 DHNGKPILLL NDEKLVTFYD NKLYGGQQFE RLLTEFKCIT EVIQLEELSI SEVACAIGSN 490 500 510 520 530 540 RPSNASVIAW AASDLAQKKI KEALLPLVDQ LFKRATYILR RLVDIVDRMI ENKKKSSFRR 550 560 570 580 590 600 HGNSTSLFQD NSSPSSQSQS QSSSISQSAS LSSENMIYGI QSINGSDSVS RPSHENTIVN 610 620 630 640 650 660 VEDHPYFIYS VKEMYFKYVD QIAADCKNKC MDEFYTTRLI YWDLQSNKDL KKFCTDSPCV 670 680 690 700 710 720 SLNNSLNNNN KSTTPGNNNN NNNNNSNNNY NNSNHILNPK ETHTMVTELA SKLFQDIRNR 730 740 750 760 770 780 MSKNIMLKCY NYFLIPMQMD LKLNIQDNIT KLSDAMLEEI FEIQTTKERL REDEQHLAQI 790 800 CNQFIQQEEN YKKYSQSFSH PFPSAVRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Evolutionary linkage between eukaryotic cytokinesis and chloroplast division by dynamin proteins." Miyagishima S.Y., Kuwayama H., Urushihara H., Nakanishi H. Proc. Natl. Acad. Sci. U.S.A. 105:15202-15207(2008) [PubMed: 18809930] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000082 Genomic DNA. Translation: EAL64500.1.
RefSeq	XP_638012.1. XM_632920.1.
3D structure databases
ProteinModelPortal	Q54MH8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0302371; DDB0302371; DDB_G0285931.
GeneID	8625363.
GenomeReviews	Gene locus dlpB in contig CM000153_GR.
KEGG	ddi:DDB_G0285931.
Organism-specific databases
dictyBase	DDB_G0285931. dlpB.
Phylogenomic databases
eggNOG	KOG0446.
GeneTree	EPrGT00060000009519.
HOGENOM	HBG464489.
ProtClustDB	CLSZ2430155.
Family and domain databases
InterPro	IPR001401. Dynamin_GTPase. [Graphical view]
Pfam	PF00350. Dynamin_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLPB_DICDI

Accession

Primary (citable) accession number: Q54MH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)