Reviewed, UniProtKB/Swiss-Prot Q54MB5 (ADK_DICDI)

Names and origin

Protein names

Recommended name:
    Adenosine kinase
      Short name=AK
    EC=2.7.1.20
Alternative name(s):
    Adenosine 5'-phosphotransferase

Gene names

Name:	adk
ORF Names:	DDB_G0286057

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives By similarity.
Catalytic activity	ATP + adenosine = ADP + AMP.
Cofactor	Magnesium By similarity.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine 3',5'-bisphosphate: step 1/1.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.

Ontologies

Keywords
Biological process	Purine salvage
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenosine kinase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Adenosine kinase		PRO_0000330873
Sites
	Active site	293	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54MB5-1 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: DBD310470ABE8450	FASTA	340	37,095
	10 20 30 40 50 60 MSNIKILCAG NPLLDLSTHV EMAILDKYEL KLGNAILAED KHLPLYGEIK SGKVEYIPGG 70 80 90 100 110 120 AAQNTSRVCQ WMLKDKQTVC YTGCVGTDEN ATILKTATES NGVVTKYQVD SSAPTGACAV 130 140 150 160 170 180 LINHKERSMV TNLGAANNFK IAHFQTEEMK AIVNSAQFFY LVGYFLTVSP DSAVHLGKHA 190 200 210 220 230 240 AENDKPFLYG LAAPFLIDFF FDKVSELLPY VDIVFANESE AATLGRKMNW GEDLTVIAEK 250 260 270 280 290 300 LAAWEKVNTK RTRTVVFTQG PDATLVFQNG VLTKYNPIKV ATEDILDLNA AGDSFCGGFL 310 320 330 340 AAYSNGQEIA KCVEAGHYAS WEIIRQNGAT VPASEPKIQF

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000085 Genomic DNA. Translation: EAL64407.2.
RefSeq	XP_637919.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54MB5.
Genome annotation databases
GeneID	3389479.
GenomeReviews	Gene locus adk in contig CM000153_GR.
KEGG	ddi:DDB_0230174.
Organism-specific databases
dictyBase	DDB_G0286057. adk.
Family and domain databases
InterPro	IPR001805. Adenokinase. IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. [Graphical view]
PANTHER	PTHR10584:SF24. Adenokinase. 1 hit.
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PRINTS	PR00989. ADENOKINASE.
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADK_DICDI

Accession

Primary (citable) accession number: Q54MB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 2, 2006
Last modified:	September 22, 2009
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)