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Q54M18

- ARG56_DICDI

UniProt

Q54M18 - ARG56_DICDI

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Protein

Bifunctional protein argC, mitochondrial

Gene

argC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.
ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei665 – 6651PROSITE-ProRule annotation

GO - Molecular functioni

  1. acetylglutamate kinase activity Source: dictyBase
  2. ATP binding Source: UniProtKB-KW
  3. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: dictyBase
  4. NAD binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: dictyBase
  2. ornithine biosynthetic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Oxidoreductase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, NADP, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00107.
UPA00068; UER00108.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein argC, mitochondrial
Including the following 2 domains:
N-acetyl-gamma-glutamyl-phosphate reductase (EC:1.2.1.38)
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name:
NAGSA dehydrogenase
Acetylglutamate kinase (EC:2.7.2.8)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name:
AGK
Gene namesi
Name:argC
ORF Names:DDB_G0286257
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0286257. argC.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 847Bifunctional protein argC, mitochondrialPRO_0000332966
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PRIDEiQ54M18.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231462.

Structurei

3D structure databases

ProteinModelPortaliQ54M18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini352 – 508157N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni100 – 331232Acetylglutamate kinaseAdd
BLAST
Regioni531 – 846316N-acetyl-gamma-glutamyl-phosphate reductaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 386Poly-Ser
Compositional biasi66 – 694Poly-Ser
Compositional biasi426 – 4294Poly-Phe

Sequence similaritiesi

In the N-terminal section; belongs to the acetylglutamate kinase family.Curated
In the C-terminal section; belongs to the NAGSA dehydrogenase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0548.
InParanoidiQ54M18.
KOiK12659.
OMAiDENRAWH.
PhylomeDBiQ54M18.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR004662. AcgluKinase.
IPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR006855. DUF619.
IPR016040. NAD(P)-bd_dom.
IPR011241. NAGK_NAGSA.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF04768. DUF619. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF036440. ARG5-6. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.
TIGR01850. argC. 1 hit.
PROSITEiPS01224. ARGC. 1 hit.
PS51731. GNAT_NAGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54M18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRNSNKLIK SVIKNESTLL KCKNNNQRVV NYSSSSTSIT SGNGIYSQIK
60 70 80 90 100
KIEEFVSKKP SVTKVSSSSA TINFNTSKSG STNTTAVDYS KSVKIKDQKQ
110 120 130 140 150
IVLVKIGGGV IESDISSLIG SLNFLKKIGL FPIVVHGGGP QLNAELAAAG
160 170 180 190 200
EPAEYVEGLR VTPPSVLAIA QRVFLRENLK IVEALESSGT KARPVTQGVY
210 220 230 240 250
QATPLDPKLY GFVGNVTKIH TDALASCITN DYVPVISSLA MTPEGQVLNI
260 270 280 290 300
NADVAALELA KSINPLKILF INTTAGMKDG DGKVMQHIKL DEQYADLMKQ
310 320 330 340 350
PWVKHGTKLK LKEFKSCLDV LPPSTSITIT SPDLLMKELF AKDGSGTTVE
360 370 380 390 400
RGEVMHSHES PSFDETKFFA LIEKSTGTKG GRIDYQQLKT DLSKGVVKAF
410 420 430 440 450
VNSHYTAGIL VRPLSSGSSV SYVDQFFFFN NSIQSTEDSE SVFKKMFENS
460 470 480 490 500
SYIWKESSNN QLNNEWFKKI ATGFITGATN NIFWTNIDTN KIENSIKECL
510 520 530 540 550
SQSSTYLSGI TKAASSKSAS EKLLQDKNHK FRVGLIGARG FTGGNLVRLI
560 570 580 590 600
DGHPNLELAI ASSSTNFGKP ITTEFPQLKS NLKFDNVKPE NIDIFTRDHG
610 620 630 640 650
IDGWFMALPD KISSPYIQTL ENSSESPVLV DLSSDHRFNE KWTYGQPETN
660 670 680 690 700
RAAIKESKLI ANPGCYATGM FLTLKPFVND LVTPPSCFGI SGYSGAGSKP
710 720 730 740 750
SEKNDPTRLS DNILPYKLVQ HTHELEVSHQ LGSPIYFMPH VGQFFQGITL
760 770 780 790 800
TISMELKYPM TKEQVVERYQ KFYQNEPLIK IDKDGIPEVK SNSGKHTVTI
810 820 830 840
GGFAVNGNHL VVVTTLDNLL KGAATQALQN MNICLGLDEL ASIKNEL
Length:847
Mass (Da):92,818
Last modified:May 24, 2005 - v1
Checksum:i94C780A710C5B3FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000085 Genomic DNA. Translation: EAL64304.1.
RefSeqiXP_637813.1. XM_632721.1.

Genome annotation databases

EnsemblProtistsiDDB0231462; DDB0231462; DDB_G0286257.
GeneIDi8625527.
KEGGiddi:DDB_G0286257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000085 Genomic DNA. Translation: EAL64304.1 .
RefSeqi XP_637813.1. XM_632721.1.

3D structure databases

ProteinModelPortali Q54M18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231462.

Proteomic databases

PRIDEi Q54M18.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231462 ; DDB0231462 ; DDB_G0286257 .
GeneIDi 8625527.
KEGGi ddi:DDB_G0286257.

Organism-specific databases

dictyBasei DDB_G0286257. argC.

Phylogenomic databases

eggNOGi COG0548.
InParanoidi Q54M18.
KOi K12659.
OMAi DENRAWH.
PhylomeDBi Q54M18.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00107 .
UPA00068 ; UER00108 .

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR004662. AcgluKinase.
IPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR006855. DUF619.
IPR016040. NAD(P)-bd_dom.
IPR011241. NAGK_NAGSA.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
PF04768. DUF619. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF036440. ARG5-6. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR00761. argB. 1 hit.
TIGR01850. argC. 1 hit.
PROSITEi PS01224. ARGC. 1 hit.
PS51731. GNAT_NAGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. Bienvenut W.V., Ura S., Insall R.H.
    Submitted (JUL-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 65-78; 161-172 AND 209-218, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: AX2.

Entry informationi

Entry nameiARG56_DICDI
AccessioniPrimary (citable) accession number: Q54M18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Multifunctional enzyme, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3