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Q54M18 (ARG56_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional protein argC, mitochondrial

Including the following 2 domains:

  1. N-acetyl-gamma-glutamyl-phosphate reductase
    EC=1.2.1.38
    Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
    Short name=NAGSA dehydrogenase
  2. Acetylglutamate kinase
    EC=2.7.2.8
    Alternative name(s):
    N-acetyl-L-glutamate 5-phosphotransferase
    NAG kinase
    Short name=AGK
Gene names
Name:argC
ORF Names:DDB_G0286257
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length847 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

In the N-terminal section; belongs to the acetylglutamate kinase family.

In the C-terminal section; belongs to the NAGSA dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 847Bifunctional protein argC, mitochondrialPRO_0000332966

Regions

Region100 – 331232Acetylglutamate kinase
Region531 – 846316N-acetyl-gamma-glutamyl-phosphate reductase
Compositional bias33 – 386Poly-Ser
Compositional bias66 – 694Poly-Ser
Compositional bias426 – 4294Poly-Phe

Sites

Active site6651 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54M18 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 94C780A710C5B3FB

FASTA84792,818
        10         20         30         40         50         60 
MLRNSNKLIK SVIKNESTLL KCKNNNQRVV NYSSSSTSIT SGNGIYSQIK KIEEFVSKKP 

        70         80         90        100        110        120 
SVTKVSSSSA TINFNTSKSG STNTTAVDYS KSVKIKDQKQ IVLVKIGGGV IESDISSLIG 

       130        140        150        160        170        180 
SLNFLKKIGL FPIVVHGGGP QLNAELAAAG EPAEYVEGLR VTPPSVLAIA QRVFLRENLK 

       190        200        210        220        230        240 
IVEALESSGT KARPVTQGVY QATPLDPKLY GFVGNVTKIH TDALASCITN DYVPVISSLA 

       250        260        270        280        290        300 
MTPEGQVLNI NADVAALELA KSINPLKILF INTTAGMKDG DGKVMQHIKL DEQYADLMKQ 

       310        320        330        340        350        360 
PWVKHGTKLK LKEFKSCLDV LPPSTSITIT SPDLLMKELF AKDGSGTTVE RGEVMHSHES 

       370        380        390        400        410        420 
PSFDETKFFA LIEKSTGTKG GRIDYQQLKT DLSKGVVKAF VNSHYTAGIL VRPLSSGSSV 

       430        440        450        460        470        480 
SYVDQFFFFN NSIQSTEDSE SVFKKMFENS SYIWKESSNN QLNNEWFKKI ATGFITGATN 

       490        500        510        520        530        540 
NIFWTNIDTN KIENSIKECL SQSSTYLSGI TKAASSKSAS EKLLQDKNHK FRVGLIGARG 

       550        560        570        580        590        600 
FTGGNLVRLI DGHPNLELAI ASSSTNFGKP ITTEFPQLKS NLKFDNVKPE NIDIFTRDHG 

       610        620        630        640        650        660 
IDGWFMALPD KISSPYIQTL ENSSESPVLV DLSSDHRFNE KWTYGQPETN RAAIKESKLI 

       670        680        690        700        710        720 
ANPGCYATGM FLTLKPFVND LVTPPSCFGI SGYSGAGSKP SEKNDPTRLS DNILPYKLVQ 

       730        740        750        760        770        780 
HTHELEVSHQ LGSPIYFMPH VGQFFQGITL TISMELKYPM TKEQVVERYQ KFYQNEPLIK 

       790        800        810        820        830        840 
IDKDGIPEVK SNSGKHTVTI GGFAVNGNHL VVVTTLDNLL KGAATQALQN MNICLGLDEL 


ASIKNEL 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]Bienvenut W.V., Ura S., Insall R.H.
Submitted (JUL-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 65-78; 161-172 AND 209-218, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: AX2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000085 Genomic DNA. Translation: EAL64304.1.

3D structure databases

ProteinModelPortalQ54M18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231462.

Proteomic databases

PRIDEQ54M18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231462; DDB0231462; DDB_G0286257.
KEGGddi:DDB_G0286257.

Organism-specific databases

dictyBaseDDB_G0286257. argC.

Phylogenomic databases

eggNOGCOG0548.
KOK12659.
OMADENRAWH.
PhylomeDBQ54M18.

Enzyme and pathway databases

UniPathwayUPA00068; UER00107.
UPA00068; UER00108.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR004662. AcgluKinase.
IPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR006855. DUF619.
IPR016040. NAD(P)-bd_dom.
IPR011241. NAGK_NAGSA.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
PF04768. DUF619. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF036440. ARG5-6. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMSSF53633. SSF53633. 1 hit.
TIGRFAMsTIGR00761. argB. 1 hit.
TIGR01850. argC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARG56_DICDI
AccessionPrimary (citable) accession number: Q54M18
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase