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Q54M18

- ARG56_DICDI

UniProt

Q54M18 - ARG56_DICDI

Protein

Bifunctional protein argC, mitochondrial

Gene

argC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.
    ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei665 – 6651PROSITE-ProRule annotation

    GO - Molecular functioni

    1. acetylglutamate kinase activity Source: dictyBase
    2. ATP binding Source: UniProtKB-KW
    3. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: dictyBase
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: dictyBase
    2. ornithine biosynthetic process Source: dictyBase

    Keywords - Molecular functioni

    Kinase, Oxidoreductase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, NADP, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00107.
    UPA00068; UER00108.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein argC, mitochondrial
    Including the following 2 domains:
    N-acetyl-gamma-glutamyl-phosphate reductase (EC:1.2.1.38)
    Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
    Short name:
    NAGSA dehydrogenase
    Acetylglutamate kinase (EC:2.7.2.8)
    Alternative name(s):
    N-acetyl-L-glutamate 5-phosphotransferase
    NAG kinase
    Short name:
    AGK
    Gene namesi
    Name:argC
    ORF Names:DDB_G0286257
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0286257. argC.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 847Bifunctional protein argC, mitochondrialPRO_0000332966
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PRIDEiQ54M18.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231462.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54M18.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni100 – 331232Acetylglutamate kinaseAdd
    BLAST
    Regioni531 – 846316N-acetyl-gamma-glutamyl-phosphate reductaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 386Poly-Ser
    Compositional biasi66 – 694Poly-Ser
    Compositional biasi426 – 4294Poly-Phe

    Sequence similaritiesi

    In the N-terminal section; belongs to the acetylglutamate kinase family.Curated
    In the C-terminal section; belongs to the NAGSA dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0548.
    KOiK12659.
    OMAiDENRAWH.
    PhylomeDBiQ54M18.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR004662. AcgluKinase.
    IPR023013. AGPR_AS.
    IPR000706. AGPR_type-1.
    IPR001048. Asp/Glu/Uridylate_kinase.
    IPR006855. DUF619.
    IPR016040. NAD(P)-bd_dom.
    IPR011241. NAGK_NAGSA.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    PF04768. DUF619. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036440. ARG5-6. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR00761. argB. 1 hit.
    TIGR01850. argC. 1 hit.
    PROSITEiPS01224. ARGC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54M18-1 [UniParc]FASTAAdd to Basket

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    MLRNSNKLIK SVIKNESTLL KCKNNNQRVV NYSSSSTSIT SGNGIYSQIK    50
    KIEEFVSKKP SVTKVSSSSA TINFNTSKSG STNTTAVDYS KSVKIKDQKQ 100
    IVLVKIGGGV IESDISSLIG SLNFLKKIGL FPIVVHGGGP QLNAELAAAG 150
    EPAEYVEGLR VTPPSVLAIA QRVFLRENLK IVEALESSGT KARPVTQGVY 200
    QATPLDPKLY GFVGNVTKIH TDALASCITN DYVPVISSLA MTPEGQVLNI 250
    NADVAALELA KSINPLKILF INTTAGMKDG DGKVMQHIKL DEQYADLMKQ 300
    PWVKHGTKLK LKEFKSCLDV LPPSTSITIT SPDLLMKELF AKDGSGTTVE 350
    RGEVMHSHES PSFDETKFFA LIEKSTGTKG GRIDYQQLKT DLSKGVVKAF 400
    VNSHYTAGIL VRPLSSGSSV SYVDQFFFFN NSIQSTEDSE SVFKKMFENS 450
    SYIWKESSNN QLNNEWFKKI ATGFITGATN NIFWTNIDTN KIENSIKECL 500
    SQSSTYLSGI TKAASSKSAS EKLLQDKNHK FRVGLIGARG FTGGNLVRLI 550
    DGHPNLELAI ASSSTNFGKP ITTEFPQLKS NLKFDNVKPE NIDIFTRDHG 600
    IDGWFMALPD KISSPYIQTL ENSSESPVLV DLSSDHRFNE KWTYGQPETN 650
    RAAIKESKLI ANPGCYATGM FLTLKPFVND LVTPPSCFGI SGYSGAGSKP 700
    SEKNDPTRLS DNILPYKLVQ HTHELEVSHQ LGSPIYFMPH VGQFFQGITL 750
    TISMELKYPM TKEQVVERYQ KFYQNEPLIK IDKDGIPEVK SNSGKHTVTI 800
    GGFAVNGNHL VVVTTLDNLL KGAATQALQN MNICLGLDEL ASIKNEL 847
    Length:847
    Mass (Da):92,818
    Last modified:May 24, 2005 - v1
    Checksum:i94C780A710C5B3FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000085 Genomic DNA. Translation: EAL64304.1.
    RefSeqiXP_637813.1. XM_632721.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231462; DDB0231462; DDB_G0286257.
    GeneIDi8625527.
    KEGGiddi:DDB_G0286257.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000085 Genomic DNA. Translation: EAL64304.1 .
    RefSeqi XP_637813.1. XM_632721.1.

    3D structure databases

    ProteinModelPortali Q54M18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231462.

    Proteomic databases

    PRIDEi Q54M18.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231462 ; DDB0231462 ; DDB_G0286257 .
    GeneIDi 8625527.
    KEGGi ddi:DDB_G0286257.

    Organism-specific databases

    dictyBasei DDB_G0286257. argC.

    Phylogenomic databases

    eggNOGi COG0548.
    KOi K12659.
    OMAi DENRAWH.
    PhylomeDBi Q54M18.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00107 .
    UPA00068 ; UER00108 .

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR004662. AcgluKinase.
    IPR023013. AGPR_AS.
    IPR000706. AGPR_type-1.
    IPR001048. Asp/Glu/Uridylate_kinase.
    IPR006855. DUF619.
    IPR016040. NAD(P)-bd_dom.
    IPR011241. NAGK_NAGSA.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    PF04768. DUF619. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036440. ARG5-6. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR00761. argB. 1 hit.
    TIGR01850. argC. 1 hit.
    PROSITEi PS01224. ARGC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. Bienvenut W.V., Ura S., Insall R.H.
      Submitted (JUL-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 65-78; 161-172 AND 209-218, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: AX2.

    Entry informationi

    Entry nameiARG56_DICDI
    AccessioniPrimary (citable) accession number: Q54M18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Multifunctional enzyme, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3