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Protein

Structural maintenance of chromosomes protein 4

Gene

smc4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi189 – 196ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-2299718 Condensation of Prophase Chromosomes
R-DDI-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 4
Short name:
SMC protein 4
Short name:
SMC-4
Gene namesi
Name:smc4
ORF Names:DDB_G0286403
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0286403 smc4

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003281401 – 1415Structural maintenance of chromosomes protein 4Add BLAST1415

Proteomic databases

PaxDbiQ54LV0
PRIDEiQ54LV0

Interactioni

Subunit structurei

Forms a heterodimer with smc2. Component of the condensin complex, which contains the smc2-smc4 heterodimer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0219935

Structurei

3D structure databases

ProteinModelPortaliQ54LV0
SMRiQ54LV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni683 – 852Flexible hingeBy similarityAdd BLAST170

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili361 – 479Sequence analysisAdd BLAST119
Coiled coili533 – 675Sequence analysisAdd BLAST143
Coiled coili855 – 1120Sequence analysisAdd BLAST266
Coiled coili1162 – 1233Sequence analysisAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 17Poly-Glu5
Compositional biasi33 – 60Poly-GluAdd BLAST28
Compositional biasi115 – 118Poly-Gln4
Compositional biasi1386 – 1391Poly-Thr6
Compositional biasi1395 – 1409Poly-GlnAdd BLAST15

Domaini

The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with smc2 forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC4 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0996 Eukaryota
COG1196 LUCA
InParanoidiQ54LV0
KOiK06675
OMAiGIYKTYN
PhylomeDBiQ54LV0

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF75553 SSF75553, 1 hit

Sequencei

Sequence statusi: Complete.

Q54LV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEDEEINDQ ISEEEEEKKK NNDSDEEMKD IDEEEEEEEE EEEEEEEEEK
60 70 80 90 100
EEEEEEEEEE TPKKPMPPPQ SKAKPSSQPP DIKKASQQSQ TQKNTPPPIQ
110 120 130 140 150
TSQSSQSSQS SQSSQQQQPK NISQTQQPKN TPPLQSSQTS QTSQKTPVSS
160 170 180 190 200
NNGIEKRLMI TKMVMENFKS YAGAQEVGPF HKCFSSVVGP NGSGKSNVID
210 220 230 240 250
AMLFVFGYRA KQIRLNKISE LIHNSENHKN LTNGRVSVHF QEIIDLPGED
260 270 280 290 300
NYEVVKGSEF VVTRTAQKTG NNKDGVSKYY LNDKVVKLDD LKTILKDKGI
310 320 330 340 350
DLDNNRFLIL QGEVEQIAMM KPKGVHPGEE GLLEYLEDII GSKKYLPDIE
360 370 380 390 400
ATSKLIEDIG DKRTSSNNRM KVVEKEKDAL QQERDNALEY IDKELKLIHC
410 420 430 440 450
KSIHYQIGRS KPEREKNEIA AKQEMVEKQL EQELVTQKAS NDKLLEFEKN
460 470 480 490 500
LKQQNKQLDE LNKQMAKCKN ELLTTEKKGV KYKEETKHLK TKVKKNNSVI
510 520 530 540 550
EEETKKQAEF ERSTIIHKQD IVRFEKEYVE LPKELIVEEK KLESMLNSLK
560 570 580 590 600
GEVTELQREM EEKQKQLLPW SKKHSEAKAV VDLKTSELAV LSKDFNGATQ
610 620 630 640 650
NLDDAIKALE DAKTISSTRK NNITKSKKEL ESVKAIIVDL EKRLASGKVT
660 670 680 690 700
EENLYRNTMD AKRQLEQIKT NLSENSSRNT ILDRLLKIKE SGQISGIHGR
710 720 730 740 750
LGDLGAIDQK YDVAISTAAF SQMDNIIVET TAAAEACVEL LRKENLGRAT
760 770 780 790 800
FMILENLEYQ RQNLGPVQTP NNTPRLFDLI KMKDEKKYAT AFFTAVGHTL
810 820 830 840 850
VADTLDEATK IAYGAKRHRV VTLDGSLIDT SGAMSGGGLK PRVGAMNSKL
860 870 880 890 900
KGDPKEDKKK LIELQDNLSQ LDSDLRQCRD ELVEIENQIQ QAQNRRSELE
910 920 930 940 950
LELPKMDMDI KAAITKCEEL TKVIPQLKNK AKLSTEKKEQ IDSIKESLIV
960 970 980 990 1000
DQKSLDKVQE KVNKLESEVQ EIQNSILNVG GPQLKMQKNK VESLQSRIDS
1010 1020 1030 1040 1050
NQTNTTKANV QIKSLAKSME KSIKILNENT KEKDENEAAL AEILEKYKSL
1060 1070 1080 1090 1100
EKENLKATEA MEAVSEQLRE KEEETKEIRK EHEKAKKVIE KIKVSNSKLE
1110 1120 1130 1140 1150
TQIEEFKTLI NEKQAEIADC LSKFANQAKK AKIYKDYVDE SLINQVSAIL
1160 1170 1180 1190 1200
TPEEIEQYME ATEQQNLIAK IHELTTQIQK ISKENNVNIE VVKDFQKKEQ
1210 1220 1230 1240 1250
EYHSRKAEFD EIEKERDNLS KRYESLRKNR LDEFMAGFTI ITMKLKEIYQ
1260 1270 1280 1290 1300
MITLGGDAEL EIIDREDPFQ EGISFSVRPP KKSWKNISNL SGGEKTLSSL
1310 1320 1330 1340 1350
ALVFALHHYK PNALYVMDEI DAALDFKNVS IIANYIKERT KNAQFIIISL
1360 1370 1380 1390 1400
RNYMFELADR LVGIYKTDNC TKSVTINPNS FTSLSTTTTT TNNSQQQQQQ
1410
KQQQKQQQQN STSQK
Length:1,415
Mass (Da):161,555
Last modified:May 24, 2005 - v1
Checksum:i75444BC92B3FD95D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000085 Genomic DNA Translation: EAL64226.1
RefSeqiXP_637730.1, XM_632638.1

Genome annotation databases

EnsemblProtistsiEAL64226; EAL64226; DDB_G0286403
GeneIDi8625595
KEGGiddi:DDB_G0286403

Entry informationi

Entry nameiSMC4_DICDI
AccessioniPrimary (citable) accession number: Q54LV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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