Reviewed, UniProtKB/Swiss-Prot Q54LQ6 (ITPA_DICDI)

Names and origin

Protein names

Recommended name:
    Probable inosine triphosphate pyrophosphatase
      Short name=ITPase
      Short name=Inosine triphosphatase
    EC=3.6.1.19

Gene names

Name:	itpa
ORF Names:	DDB_G0286495

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes ITP and dITP to their respective monophosphate derivatives By similarity.
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Probable inosine triphosphate pyrophosphatase		PRO_0000328399
Sites
	Metal binding	39	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54LQ6-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: B8A4AB1217C26D0E	FASTA	194	21,730
	10 20 30 40 50 60 MSISKKIVFV TGNAKKLEEA LQILGTSFPI ESKKVDLPEL QGDPIDISIE KCKIAAREVG 70 80 90 100 110 120 GPVLVEDTCL CFNALKGLPG PYVKWFLDKL EPEGLYKLLD AWEDKSAYAL CNFAFSEGPD 130 140 150 160 170 180 SEPIVFAGKT DGIIVQPRGP RNFGWDPVFQ PDGYKETYAE MDKSIKNTIS HRTRSLQKVK 190 EFLKSKGYEN CKFE

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000086 Genomic DNA. Translation: EAL64198.1.
RefSeq	XP_637700.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3389275.
KEGG	ddi:DDB_0238062.
Organism-specific databases
dictyBase	DDB_G0286495. itpa.
Phylogenomic databases
OMA	Q54LQ6. NAISHRR.
Enzyme and pathway databases
BRENDA	3.6.1.19. 424.
Family and domain databases
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ITPA_DICDI

Accession

Primary (citable) accession number: Q54LQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)