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Protein

Ubiquitin-conjugating enzyme E2 J2

Gene

ube2j2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 J2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme J2
Gene namesi
Name:ube2j2
ORF Names:DDB_G0286511
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0286511

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 219CytoplasmicSequence analysisAdd BLAST219
Transmembranei220 – 240Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini241LumenalSequence analysis1

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003292841 – 241Ubiquitin-conjugating enzyme E2 J2Add BLAST241

Proteomic databases

PaxDbiQ54LP7

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ54LP7, 2 interactors
STRINGi44689.DDB0233839

Structurei

3D structure databases

ProteinModelPortaliQ54LP7
SMRiQ54LP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 195Ser-richAdd BLAST26

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0894 Eukaryota
ENOG410Z0AN LUCA
InParanoidiQ54LP7
KOiK04554
OMAiWEKWRWG
PhylomeDBiQ54LP7

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q54LP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQVCVTRL KKELLALSKN EDIKDIFIAK PSISNILEWH YVIYGPPDTP
60 70 80 90 100
YHGGYYHGQI IFPVEYPYKP PSILMTTPSG RFVCNSRICT SMSDFHPDTW
110 120 130 140 150
SPFWSNCTII LGLISFMTED ENGFGSIVKS KETRKQLASQ SMAFNLKNPV
160 170 180 190 200
FVKLFPELIS DYKKKGTFYS SSSTPSSTPP PSSTPSSSSS SSNISKRNVP
210 220 230 240
IPTTKTTPQD TNKKKEQKNN NIPYIILFIA LIIILLYLFL K
Length:241
Mass (Da):27,154
Last modified:May 24, 2005 - v1
Checksum:iF047CE7C91D620AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000087 Genomic DNA Translation: EAL64182.1
RefSeqiXP_637685.1, XM_632593.1

Genome annotation databases

EnsemblProtistsiEAL64182; EAL64182; DDB_G0286511
GeneIDi8625651
KEGGiddi:DDB_G0286511

Similar proteinsi

Entry informationi

Entry nameiUB2J2_DICDI
AccessioniPrimary (citable) accession number: Q54LP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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