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Protein

Dolichol-phosphate mannosyltransferase subunit 1

Gene

dpm1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.By similarity

Catalytic activityi

GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-DDI-162699. Synthesis of dolichyl-phosphate mannose.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol-phosphate mannosyltransferase subunit 1 (EC:2.4.1.83)
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 1
Short name:
DPM synthase subunit 1
Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Mannose-P-dolichol synthase subunit 1
Short name:
MPD synthase subunit 1
Gene namesi
Name:dpm1
Synonyms:dgtB
ORF Names:DDB_G0286519
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0286519. dgtB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Dolichol-phosphate mannosyltransferase subunit 1PRO_0000327894Add
BLAST

Proteomic databases

PaxDbiQ54LP3.
PRIDEiQ54LP3.

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of dpm1, dpm2 and dpm3.

Protein-protein interaction databases

STRINGi44689.DDB0231708.

Structurei

3D structure databases

ProteinModelPortaliQ54LP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

eggNOGiKOG2978. Eukaryota.
COG0463. LUCA.
InParanoidiQ54LP3.
KOiK00721.
OMAiTAYIHGF.
PhylomeDBiQ54LP3.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54LP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKNRSDKS SSSSITKDKY TIILPTYKER ENLPIIIWLI STELEKCFID
60 70 80 90 100
YEVVIVEDNS PDGTLEVAQQ LQKIYGEEKI KILSRPGKMG LGSAYMDGIK
110 120 130 140 150
KSTGNWVILM DADLSHHPKF IPQFIEKQKK LNCEIVTGTR YQSGGGVFGW
160 170 180 190 200
NLYRKLTSRV ANYIASVLLT PGVSDLTGSF RLYRKDVLEK LITQNKSKGY
210 220 230 240 250
VFQVEMMVRA NQLGYQVGEV PITFVDRIFG VSNLDSGEIV GFLKSVLNLF

MNIE
Length:254
Mass (Da):28,698
Last modified:May 24, 2005 - v1
Checksum:i3A547C62A8152C0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000087 Genomic DNA. Translation: EAL64186.1.
RefSeqiXP_637689.1. XM_632597.1.

Genome annotation databases

EnsemblProtistsiDDB0231708; DDB0231708; DDB_G0286519.
GeneIDi8625655.
KEGGiddi:DDB_G0286519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000087 Genomic DNA. Translation: EAL64186.1.
RefSeqiXP_637689.1. XM_632597.1.

3D structure databases

ProteinModelPortaliQ54LP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231708.

Proteomic databases

PaxDbiQ54LP3.
PRIDEiQ54LP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231708; DDB0231708; DDB_G0286519.
GeneIDi8625655.
KEGGiddi:DDB_G0286519.

Organism-specific databases

dictyBaseiDDB_G0286519. dgtB.

Phylogenomic databases

eggNOGiKOG2978. Eukaryota.
COG0463. LUCA.
InParanoidiQ54LP3.
KOiK00721.
OMAiTAYIHGF.
PhylomeDBiQ54LP3.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-DDI-162699. Synthesis of dolichyl-phosphate mannose.

Miscellaneous databases

PROiQ54LP3.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiDPM1_DICDI
AccessioniPrimary (citable) accession number: Q54LP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.