Q54LN9 (ACMSD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
EC=4.1.1.45

Alternative name(s):
Picolinate carboxylase

Gene names

Name:	acmsd
ORF Names:	DDB_G0286525

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS) By similarity.
Catalytic activity	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.
Pathway	Secondary metabolite metabolism; quinolate metabolism.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the ACMSD family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	quinolinate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	aminocarboxymuconate-semialdehyde decarboxylase activity Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase		PRO_0000327893
Regions
	Compositional bias	6 – 13	8	Poly-Thr
Sites
	Metal binding	29	1	Zinc By similarity
	Metal binding	31	1	Zinc By similarity
	Metal binding	197	1	Zinc By similarity
	Metal binding	314	1	Zinc By similarity
	Binding site	70	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54LN9 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 50DDD1BDEE180594	FASTA	359	40,451
	10 20 30 40 50 60 MENKETTTTT TTTNNGSDKK KRSLKIDLHT HILPKNWPNL KEKYGYGGWV SLDHHCSCKA 70 80 90 100 110 120 KMMIDGKFFR EIDSNCWDPD VRIQELNRDD VDIQVLSTVP VMFGYWAKPQ DALDLAQYLN 130 140 150 160 170 180 DHIAQVVSEN PKRFIGLGSL PMQCTESSIQ ELRRCILELG LPGIQIGSNV NGKNLDDPSL 190 200 210 220 230 240 FPIFEECEKL GAAVFIHPWE MVGKDRMPQY WLPWLVGMPA ETCLAICSMI FGGVFQRLPN 250 260 270 280 290 300 LKVCFAHGGG SFPFTIGRIE HGFNARPDLC AVVNPINPRE YIGKFWVDSL VHDEEALKFL 310 320 330 340 350 VNLMGEKKVT LGTDYPFPLG ELVPGQLIES IKEFSETTKE NLLGGNALEF LGLDPNKYL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000087 Genomic DNA. Translation: EAL64189.1.
RefSeq	XP_637693.1. XM_632601.1.
3D structure databases
ProteinModelPortal	Q54LN9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54LN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0266468; DDB0266468; DDB_G0286525.
GeneID	8625659.
GenomeReviews	Gene locus acmsd in contig CM000153_GR.
KEGG	ddi:DDB_G0286525.
Organism-specific databases
dictyBase	DDB_G0286525. acmsd.
Phylogenomic databases
eggNOG	KOG4245.
HOGENOM	HBG344784.
OMA	GSHINTW.
ProtClustDB	CLSZ2430097.
Family and domain databases
InterPro	IPR006992. Amidohydro_2. [Graphical view]
KO	K03392.
Pfam	PF04909. Amidohydro_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACMSD_DICDI

Accession

Primary (citable) accession number: Q54LN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)