Reviewed, UniProtKB/Swiss-Prot Q54LE6 (ABCC5_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter C family member 5
Alternative name(s):
    ABC transporter ABCC.5

Gene names

Name:	abcC5
ORF Names:	DDB_G0286559

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1460 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1460	1460	ABC transporter C family member 5		PRO_0000363850
Regions
	Transmembrane	196 – 216	21	Potential
	Transmembrane	238 – 258	21	Potential
	Transmembrane	320 – 340	21	Potential
	Transmembrane	425 – 445	21	Potential
	Transmembrane	456 – 476	21	Potential
	Transmembrane	842 – 862	21	Potential
	Transmembrane	922 – 942	21	Potential
	Transmembrane	1014 – 1034	21	Potential
	Transmembrane	1108 – 1128	21	Potential
	Domain	196 – 482	287	ABC transmembrane type-1 1
	Domain	560 – 783	224	ABC transporter 1
	Domain	853 – 1166	314	ABC transmembrane type-1 2
	Domain	1210 – 1444	235	ABC transporter 2
	Nucleotide binding	593 – 600	8	ATP Potential
	Nucleotide binding	1244 – 1251	8	ATP Potential
	Compositional bias	15 – 20	6	Poly-Asn
	Compositional bias	38 – 41	4	Poly-Asn
	Compositional bias	44 – 53	10	Poly-Asn
	Compositional bias	543 – 546	4	Poly-Pro
Experimental info
	Sequence conflict	613 – 615	3	ENN → REY in AAL85708. Ref.2
	Sequence conflict	839	1	K → N in AAL85708. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q54LE6-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 496690ABE21E2F24	FASTA	1,460	165,282
	10 20 30 40 50 60 MKYNNLENDD SDIHNNNNNN ESEGDSLIEL EEINLEGNNN NDINNNNNIN NNNDSLDYEN 70 80 90 100 110 120 NKGSKKKNNK KYVILNEEED INDKKVENGE NETSSFTYGH DNEFKDLPLP KKGFGGLKSL 130 140 150 160 170 180 EENANFLSSM TYLWADKFVL YCFKNILQLD EIWELASYDK SSYLFDIMDK NWQNELKNSK 190 200 210 220 230 240 KPNFMKAAFK SFGKHFALSW VHFGLNVISQ FIGPIFLKKI VSFVIQYREN PGSVDPNLGY 250 260 270 280 290 300 YYALILFVNS MLGSIFLYQS NMITSRTGNR LKSLIVLYVY KKSLKLTNSS RSKKSNGEIV 310 320 330 340 350 360 NLMSNDAQRL LELFQMVNTL IFAVPMIIVS MILLYDCVGW PSFVALLVMG ISLPYSLNRG 370 380 390 400 410 420 SQLSIYRRKL VGFTDQRIKV VNEMFQAIKT IKLYAWEDYF SQKMMSKRGE EIKFLTQFVR 430 440 450 460 470 480 FRYSLIVVVQ SIPTIISIFM FTVYYLVNSK LPADKIFAAV AYLNIIRVPF TFLPYGYNIY 490 500 510 520 530 540 IQFKVSIERV VNFLNMDEIN QGDDKNNEIN VNVCDQQKQQ QTDIGIYMDN TTFSWAIKPQ 550 560 570 580 590 600 TNPPPPRTTP SNDKSSPSGN NSNNEKKEVQ VSFSLKNTSC QVKEKGSLLM VIGPVGSGKS 610 620 630 640 650 660 SFCQALLGEM ELENNGSLRV VGSIAYVSQS AWIMNASLKD NILFGKEYNK ERYEMVLNCC 670 680 690 700 710 720 ALLPDLALFP QGDLIEIGER GINLSGGQKQ RVAIARAVYS DSDIYILDDI LSAVDAHVGK 730 740 750 760 770 780 HLFYNCIKGI LKEKIVVLAT NQLNYCPYST QTLILKTGGE VEQYDTFENI ISTINSAYGN 790 800 810 820 830 840 SSLFSELLKQ YAHMAGDSDK DSDEIVDDEM IKSKENNNDL YDGKLTTIEE REEGSVSFKH 850 860 870 880 890 900 YMYYVTAGGG FLFLIALLGY CIDTSTSTFT NWWLSNWSSK HTSTGINNNN SSSSNSISSS 910 920 930 940 950 960 SSYIIDSLSS LNINEDGDIE NAGEFLGVFI AIGVLTVLLI IVRTIVFFEY SIRATTEIHK 970 980 990 1000 1010 1020 RLFWSILRAP MWFFDTVPLG RILNRFTRDT DIVDMLLTNS LNQFLNFSTN CIAILVIISI 1030 1040 1050 1060 1070 1080 ATPWLLLPMT PIIILFYFIQ YFYRRTSIQI QRIESITRSP IFSHFAETLN GVITLRAFRK 1090 1100 1110 1120 1130 1140 MGENVLKNQA LLDDNNKCYL TLQAMNQWLG LRLSVLGNLI TLLSCIFITV DRSSIAIASV 1150 1160 1170 1180 1190 1200 GLSISYTLSL TTNLNKATQQ LAELETKMNS IERISYYTEN VPQEPDQIIE SNRPPMGWPS 1210 1220 1230 1240 1250 1260 LTNSNHTPPI IFENVVMSYR QGLPAVLKGI SFEIKAGEKI GICGRTGSGK SSLLLALFRI 1270 1280 1290 1300 1310 1320 VELSSGRIII DGLDISKIGL KDLRSQLAII PQEPVMFTGT LRSNLDSLSE HTDSELWDVL 1330 1340 1350 1360 1370 1380 KEIQLYEHVK KVSVADEGLD LRVNDNWSQG QKQLIGLGRA LLKKPKILVC DEATASVDSL 1390 1400 1410 1420 1430 1440 SDELIQRIIR EKFKDAIILT IAHRLNTIVE SDRIMVLDSG SIVEFNKPSI LAQNENSLFN 1450 1460 WLIDETGTQN SQYLRSLIKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 613-1460, NOMENCLATURE. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000089 Genomic DNA. Translation: EAL64035.1. AF474337 Genomic DNA. Translation: AAL85708.1.
RefSeq	XP_637615.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ModBase	Search...
Genome annotation databases
GeneID	3389197.
GenomeReviews	Gene locus abcC5 in contig CM000153_GR.
KEGG	ddi:DDB_0220025.
Organism-specific databases
dictyBase	DDB_G0286559. abcC5.
Phylogenomic databases
OMA	GEMELEN
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCC5_DICDI

Accession

Primary (citable) accession number: Q54LE6
Secondary accession number(s): Q8T6H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	November 24, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)