Q54KM9 (RB11B_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-11B

Gene names

Name:	rab11B
ORF Names:	DDB_G0287211

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Developmental stage	Expressed at uniform levels throughout growth and development. Ref.1
Disruption phenotype	Mutants exhibit normal growth and development, and endocytosis and the structure of membrane-bound organelles is unaffected. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Ras-related protein Rab-11B		PRO_0000312421
Regions
	Nucleotide binding	18 – 25	8	GTP By similarity
	Nucleotide binding	66 – 70	5	GTP By similarity
	Nucleotide binding	124 – 127	4	GTP By similarity
	Motif	40 – 48	9	Effector region By similarity
	Compositional bias	159 – 195	37	Asn-rich
Amino acid modifications
	Lipidation	219	1	S-geranylgeranyl cysteine By similarity
	Lipidation	220	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54KM9 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: CCE7B54CAA06D04E	FASTA	220	25,335
	10 20 30 40 50 60 MVLKTIEYDY LCKIVVIGDS GVGKSNLLSR YNKNEFSVGK LSTIGVEFST KTLKIDNKLI 70 80 90 100 110 120 KLQLWDTAGQ EKYNSITESY YKGAIGALIV YNIADRNSFN NLEKWLKKFR ENAHQDYGIM 130 140 150 160 170 180 LVGNKSDLKE YREVSTLEGK QFAEKHYMQF IETSALDSNN VETAFNNLFN FIYYSLFKNK 190 200 210 220 TMTLDINNNG NNNSNIMVGD CEPIQFDQRY TINKPVYDCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a Dictyostelium gene encoding a small GTPase of the Rab11 family." Dragoi I.A., O'Halloran T.J. J. Cell. Biochem. 70:29-37(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE. Strain: AX3 / DH1.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF037357 Genomic DNA. Translation: AAB92559.1. AAFI02000099 Genomic DNA. Translation: EAL63807.1.
RefSeq	XP_637328.1. XM_632236.1.
3D structure databases
HSSP	HSSP built from PDB template 2F9L based on UniProtKB Q15907.
ProteinModelPortal	Q54KM9.
SMR	Q54KM9. Positions 8-173.
ModBase	Search...
Proteomic databases
PRIDE	Q54KM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0191421; DDB0191421; DDB_G0287211.
GeneID	8626026.
KEGG	ddi:DDB_G0287211.
Organism-specific databases
dictyBase	DDB_G0287211. rab11B.
Phylogenomic databases
eggNOG	COG1100.
KO	K07976.
OMA	ISRRSTF.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RB11B_DICDI

Accession

Primary (citable) accession number: Q54KM9
Secondary accession number(s): O43991

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)