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Q54KM7

- GCSP_DICDI

UniProt

Q54KM7 - GCSP_DICDI

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Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene
gcvP, DDB_G0287255
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
ORF Names:DDB_G0287255
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287255. gcvP.

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion Reviewed predictionAdd
BLAST
Chaini22 – 994973Glycine dehydrogenase (decarboxylating), mitochondrialUniRule annotationPRO_0000327611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei742 – 7421N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ54KM7.

Interactioni

Subunit structurei

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi44689.DDB_0231130.

Structurei

3D structure databases

ProteinModelPortaliQ54KM7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiERRDICL.
PhylomeDBiQ54KM7.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54KM7-1 [UniParc]FASTAAdd to Basket

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MLKLLRNNGI NKLKSNLIRN YSTKQSIFQA LDTFPKRHIG PNENEINEML    50
KSINTSKLSK KNPNSLEQLI EYTIPKDIRL NRELNIEENK VIGENQLLKD 100
LKKIAEKNKV YRSFIGMGYY GTITPHVIQR NILENPGWYT PYTPYQAEIS 150
QGRLESLLNF QTMVSEFTGL PMSNASLLDE ATAAAEAMQM CVNISKSKGP 200
FAFLVDKYCH PQTIDTIKTR AEPKGIRIEV VDSKDFKFTE DVVGCIVQYP 250
SSNGVITDYK EMADRAHQAN ALVVAATDLL SLALLKPPGE WGADIALGNS 300
QRFGVPLGFG GPHAAFFSTK DKYARLLPGR IIGVSKDKQG NSAFRMALQT 350
REQHIRREKA TSNICTSQAL LANMSAMYAV YHGQQGIKDI ANAVHRKAII 400
LAEGIKRLGY TVLDRPFFDT VLIITGDKTD MMIKELESRQ INVRQYCSKS 450
ISISLDETVT SADISALLNG FSAHASKPLG LSSPEQLEKE TSTISVISEE 500
FARQTPFLTH PIFNRYHSEH ELLRYIHKLQ KKDLGLTTAM IPLGSCTMKL 550
NATTEMYPVS WPEFNSIHPF VPANQSLGYK EMFESISNML CEVTGFDGCS 600
LQPNAGSQGE YAGLMVIRSY LTSIGQSQRN VCLIPVSAHG TNPASAAMVG 650
MKVVVVDCDT NGNIDVADLK AKAEKHKDTL AALMITYPST HGVFEEGAND 700
ICDIIHANGG QVYMDGANMN AQVGLCRPGD IGADVCHLNL HKTFCIPHGG 750
GGPGMGPICV KSHLAPFLPG HSVVKGVGGE RAMSAVSAGP WGSSSILPIT 800
YVYLKLMGGQ GLKKATQVAI LNANYMASRL KDHYKILYTG SHGLVAHEFI 850
IDLRMFKESA GIEAEDVAKR LQDMNFHGPT MSWPVPNTLM IEPTESESKY 900
ELDRLCDALI LIREEIREIE TGKADRKNNV LVNSPHTEKV IVADNWNYPY 950
SRSKAAFPTP ATVASKFWPT VGRIDNVHGD KNLVCSCPPL SDYQ 994
Length:994
Mass (Da):109,578
Last modified:May 24, 2005 - v1
Checksum:i920A98C4A51F90D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000099 Genomic DNA. Translation: EAL63829.1.
RefSeqiXP_637330.1. XM_632238.1.

Genome annotation databases

EnsemblProtistsiDDB0231130; DDB0231130; DDB_G0287255.
GeneIDi8626028.
KEGGiddi:DDB_G0287255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000099 Genomic DNA. Translation: EAL63829.1 .
RefSeqi XP_637330.1. XM_632238.1.

3D structure databases

ProteinModelPortali Q54KM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231130.

Proteomic databases

PRIDEi Q54KM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231130 ; DDB0231130 ; DDB_G0287255 .
GeneIDi 8626028.
KEGGi ddi:DDB_G0287255.

Organism-specific databases

dictyBasei DDB_G0287255. gcvP.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi ERRDICL.
PhylomeDBi Q54KM7.

Miscellaneous databases

PROi Q54KM7.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGCSP_DICDI
AccessioniPrimary (citable) accession number: Q54KM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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