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Q54KM7

- GCSP_DICDI

UniProt

Q54KM7 - GCSP_DICDI

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Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

gcvP

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).By similarity

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
ORF Names:DDB_G0287255
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287255. gcvP.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionSequence AnalysisAdd
BLAST
Chaini22 – 994973Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000327611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei742 – 7421N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ54KM7.

Interactioni

Subunit structurei

Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0231130.

Structurei

3D structure databases

ProteinModelPortaliQ54KM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
InParanoidiQ54KM7.
KOiK00281.
OMAiERRDICL.
PhylomeDBiQ54KM7.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54KM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKLLRNNGI NKLKSNLIRN YSTKQSIFQA LDTFPKRHIG PNENEINEML
60 70 80 90 100
KSINTSKLSK KNPNSLEQLI EYTIPKDIRL NRELNIEENK VIGENQLLKD
110 120 130 140 150
LKKIAEKNKV YRSFIGMGYY GTITPHVIQR NILENPGWYT PYTPYQAEIS
160 170 180 190 200
QGRLESLLNF QTMVSEFTGL PMSNASLLDE ATAAAEAMQM CVNISKSKGP
210 220 230 240 250
FAFLVDKYCH PQTIDTIKTR AEPKGIRIEV VDSKDFKFTE DVVGCIVQYP
260 270 280 290 300
SSNGVITDYK EMADRAHQAN ALVVAATDLL SLALLKPPGE WGADIALGNS
310 320 330 340 350
QRFGVPLGFG GPHAAFFSTK DKYARLLPGR IIGVSKDKQG NSAFRMALQT
360 370 380 390 400
REQHIRREKA TSNICTSQAL LANMSAMYAV YHGQQGIKDI ANAVHRKAII
410 420 430 440 450
LAEGIKRLGY TVLDRPFFDT VLIITGDKTD MMIKELESRQ INVRQYCSKS
460 470 480 490 500
ISISLDETVT SADISALLNG FSAHASKPLG LSSPEQLEKE TSTISVISEE
510 520 530 540 550
FARQTPFLTH PIFNRYHSEH ELLRYIHKLQ KKDLGLTTAM IPLGSCTMKL
560 570 580 590 600
NATTEMYPVS WPEFNSIHPF VPANQSLGYK EMFESISNML CEVTGFDGCS
610 620 630 640 650
LQPNAGSQGE YAGLMVIRSY LTSIGQSQRN VCLIPVSAHG TNPASAAMVG
660 670 680 690 700
MKVVVVDCDT NGNIDVADLK AKAEKHKDTL AALMITYPST HGVFEEGAND
710 720 730 740 750
ICDIIHANGG QVYMDGANMN AQVGLCRPGD IGADVCHLNL HKTFCIPHGG
760 770 780 790 800
GGPGMGPICV KSHLAPFLPG HSVVKGVGGE RAMSAVSAGP WGSSSILPIT
810 820 830 840 850
YVYLKLMGGQ GLKKATQVAI LNANYMASRL KDHYKILYTG SHGLVAHEFI
860 870 880 890 900
IDLRMFKESA GIEAEDVAKR LQDMNFHGPT MSWPVPNTLM IEPTESESKY
910 920 930 940 950
ELDRLCDALI LIREEIREIE TGKADRKNNV LVNSPHTEKV IVADNWNYPY
960 970 980 990
SRSKAAFPTP ATVASKFWPT VGRIDNVHGD KNLVCSCPPL SDYQ
Length:994
Mass (Da):109,578
Last modified:May 24, 2005 - v1
Checksum:i920A98C4A51F90D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000099 Genomic DNA. Translation: EAL63829.1.
RefSeqiXP_637330.1. XM_632238.1.

Genome annotation databases

EnsemblProtistsiDDB0231130; DDB0231130; DDB_G0287255.
GeneIDi8626028.
KEGGiddi:DDB_G0287255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000099 Genomic DNA. Translation: EAL63829.1 .
RefSeqi XP_637330.1. XM_632238.1.

3D structure databases

ProteinModelPortali Q54KM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231130.

Proteomic databases

PRIDEi Q54KM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231130 ; DDB0231130 ; DDB_G0287255 .
GeneIDi 8626028.
KEGGi ddi:DDB_G0287255.

Organism-specific databases

dictyBasei DDB_G0287255. gcvP.

Phylogenomic databases

eggNOGi COG1003.
InParanoidi Q54KM7.
KOi K00281.
OMAi ERRDICL.
PhylomeDBi Q54KM7.

Miscellaneous databases

PROi Q54KM7.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGCSP_DICDI
AccessioniPrimary (citable) accession number: Q54KM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3