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Q54KM7 (GCSP_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
ORF Names:DDB_G0287255
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length994 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP-Rule MF_00711

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_00711.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandPyridoxal phosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglycine dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: UniProtKB-EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion Potential
Chain22 – 994973Glycine dehydrogenase (decarboxylating), mitochondrial HAMAP-Rule MF_00711
PRO_0000327611

Amino acid modifications

Modified residue7421N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54KM7 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 920A98C4A51F90D0

FASTA994109,578
        10         20         30         40         50         60 
MLKLLRNNGI NKLKSNLIRN YSTKQSIFQA LDTFPKRHIG PNENEINEML KSINTSKLSK 

        70         80         90        100        110        120 
KNPNSLEQLI EYTIPKDIRL NRELNIEENK VIGENQLLKD LKKIAEKNKV YRSFIGMGYY 

       130        140        150        160        170        180 
GTITPHVIQR NILENPGWYT PYTPYQAEIS QGRLESLLNF QTMVSEFTGL PMSNASLLDE 

       190        200        210        220        230        240 
ATAAAEAMQM CVNISKSKGP FAFLVDKYCH PQTIDTIKTR AEPKGIRIEV VDSKDFKFTE 

       250        260        270        280        290        300 
DVVGCIVQYP SSNGVITDYK EMADRAHQAN ALVVAATDLL SLALLKPPGE WGADIALGNS 

       310        320        330        340        350        360 
QRFGVPLGFG GPHAAFFSTK DKYARLLPGR IIGVSKDKQG NSAFRMALQT REQHIRREKA 

       370        380        390        400        410        420 
TSNICTSQAL LANMSAMYAV YHGQQGIKDI ANAVHRKAII LAEGIKRLGY TVLDRPFFDT 

       430        440        450        460        470        480 
VLIITGDKTD MMIKELESRQ INVRQYCSKS ISISLDETVT SADISALLNG FSAHASKPLG 

       490        500        510        520        530        540 
LSSPEQLEKE TSTISVISEE FARQTPFLTH PIFNRYHSEH ELLRYIHKLQ KKDLGLTTAM 

       550        560        570        580        590        600 
IPLGSCTMKL NATTEMYPVS WPEFNSIHPF VPANQSLGYK EMFESISNML CEVTGFDGCS 

       610        620        630        640        650        660 
LQPNAGSQGE YAGLMVIRSY LTSIGQSQRN VCLIPVSAHG TNPASAAMVG MKVVVVDCDT 

       670        680        690        700        710        720 
NGNIDVADLK AKAEKHKDTL AALMITYPST HGVFEEGAND ICDIIHANGG QVYMDGANMN 

       730        740        750        760        770        780 
AQVGLCRPGD IGADVCHLNL HKTFCIPHGG GGPGMGPICV KSHLAPFLPG HSVVKGVGGE 

       790        800        810        820        830        840 
RAMSAVSAGP WGSSSILPIT YVYLKLMGGQ GLKKATQVAI LNANYMASRL KDHYKILYTG 

       850        860        870        880        890        900 
SHGLVAHEFI IDLRMFKESA GIEAEDVAKR LQDMNFHGPT MSWPVPNTLM IEPTESESKY 

       910        920        930        940        950        960 
ELDRLCDALI LIREEIREIE TGKADRKNNV LVNSPHTEKV IVADNWNYPY SRSKAAFPTP 

       970        980        990 
ATVASKFWPT VGRIDNVHGD KNLVCSCPPL SDYQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000099 Genomic DNA. Translation: EAL63829.1.

3D structure databases

ProteinModelPortalQ54KM7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231130.

Proteomic databases

PRIDEQ54KM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231130; DDB0231130; DDB_G0287255.
KEGGddi:DDB_G0287255.

Organism-specific databases

dictyBaseDDB_G0287255. gcvP.

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAQTMVCDL.
PhylomeDBQ54KM7.
ProtClustDBCLSZ2430021.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Other

PROQ54KM7.

Entry information

Entry nameGCSP_DICDI
AccessionPrimary (citable) accession number: Q54KM7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase