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Q54KM7

- GCSP_DICDI

UniProt

Q54KM7 - GCSP_DICDI

Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

gcvP

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.By similarity

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P protein
    Glycine decarboxylase
    Glycine dehydrogenase (aminomethyl-transferring)
    Gene namesi
    Name:gcvP
    ORF Names:DDB_G0287255
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0287255. gcvP.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionSequence AnalysisAdd
    BLAST
    Chaini22 – 994973Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000327611Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei742 – 7421N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ54KM7.

    Interactioni

    Subunit structurei

    Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0231130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54KM7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiERRDICL.
    PhylomeDBiQ54KM7.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54KM7-1 [UniParc]FASTAAdd to Basket

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    MLKLLRNNGI NKLKSNLIRN YSTKQSIFQA LDTFPKRHIG PNENEINEML    50
    KSINTSKLSK KNPNSLEQLI EYTIPKDIRL NRELNIEENK VIGENQLLKD 100
    LKKIAEKNKV YRSFIGMGYY GTITPHVIQR NILENPGWYT PYTPYQAEIS 150
    QGRLESLLNF QTMVSEFTGL PMSNASLLDE ATAAAEAMQM CVNISKSKGP 200
    FAFLVDKYCH PQTIDTIKTR AEPKGIRIEV VDSKDFKFTE DVVGCIVQYP 250
    SSNGVITDYK EMADRAHQAN ALVVAATDLL SLALLKPPGE WGADIALGNS 300
    QRFGVPLGFG GPHAAFFSTK DKYARLLPGR IIGVSKDKQG NSAFRMALQT 350
    REQHIRREKA TSNICTSQAL LANMSAMYAV YHGQQGIKDI ANAVHRKAII 400
    LAEGIKRLGY TVLDRPFFDT VLIITGDKTD MMIKELESRQ INVRQYCSKS 450
    ISISLDETVT SADISALLNG FSAHASKPLG LSSPEQLEKE TSTISVISEE 500
    FARQTPFLTH PIFNRYHSEH ELLRYIHKLQ KKDLGLTTAM IPLGSCTMKL 550
    NATTEMYPVS WPEFNSIHPF VPANQSLGYK EMFESISNML CEVTGFDGCS 600
    LQPNAGSQGE YAGLMVIRSY LTSIGQSQRN VCLIPVSAHG TNPASAAMVG 650
    MKVVVVDCDT NGNIDVADLK AKAEKHKDTL AALMITYPST HGVFEEGAND 700
    ICDIIHANGG QVYMDGANMN AQVGLCRPGD IGADVCHLNL HKTFCIPHGG 750
    GGPGMGPICV KSHLAPFLPG HSVVKGVGGE RAMSAVSAGP WGSSSILPIT 800
    YVYLKLMGGQ GLKKATQVAI LNANYMASRL KDHYKILYTG SHGLVAHEFI 850
    IDLRMFKESA GIEAEDVAKR LQDMNFHGPT MSWPVPNTLM IEPTESESKY 900
    ELDRLCDALI LIREEIREIE TGKADRKNNV LVNSPHTEKV IVADNWNYPY 950
    SRSKAAFPTP ATVASKFWPT VGRIDNVHGD KNLVCSCPPL SDYQ 994
    Length:994
    Mass (Da):109,578
    Last modified:May 24, 2005 - v1
    Checksum:i920A98C4A51F90D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000099 Genomic DNA. Translation: EAL63829.1.
    RefSeqiXP_637330.1. XM_632238.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231130; DDB0231130; DDB_G0287255.
    GeneIDi8626028.
    KEGGiddi:DDB_G0287255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000099 Genomic DNA. Translation: EAL63829.1 .
    RefSeqi XP_637330.1. XM_632238.1.

    3D structure databases

    ProteinModelPortali Q54KM7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231130.

    Proteomic databases

    PRIDEi Q54KM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231130 ; DDB0231130 ; DDB_G0287255 .
    GeneIDi 8626028.
    KEGGi ddi:DDB_G0287255.

    Organism-specific databases

    dictyBasei DDB_G0287255. gcvP.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi ERRDICL.
    PhylomeDBi Q54KM7.

    Miscellaneous databases

    PROi Q54KM7.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiGCSP_DICDI
    AccessioniPrimary (citable) accession number: Q54KM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3