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Protein

Kynurenine--oxoglutarate transaminase

Gene

ccbl

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity).By similarity

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
L-glutamine + phenylpyruvate = 2-oxoglutaramate + L-phenylalanine.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.

Cofactori

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes kynurenate from L-kynurenine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Kynurenine--oxoglutarate transaminase (ccbl)
  2. no protein annotated in this organism
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes kynurenate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46Substrate; via amide nitrogenBy similarity1
Binding sitei198SubstrateBy similarity1
Binding sitei413SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Lyase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-70614 Amino acid synthesis and interconversion (transamination)
R-DDI-71182 Phenylalanine and tyrosine catabolism
R-DDI-71240 Tryptophan catabolism
UniPathwayiUPA00334; UER00726

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase (EC:2.6.1.7)
Alternative name(s):
Glutamine transaminase K (EC:4.4.1.13)
Glutamine--phenylpyruvate transaminase (EC:2.6.1.64)
Kynurenine aminotransferase
Gene namesi
Name:ccbl
Synonyms:kat
ORF Names:DDB_G0287269
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287269 ccbl

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277251 – 435Kynurenine--oxoglutarate transaminaseAdd BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ54KM6

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231138

Structurei

3D structure databases

ProteinModelPortaliQ54KM6
SMRiQ54KM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0257 Eukaryota
COG0436 LUCA
InParanoidiQ54KM6
KOiK00816
OMAiTIFAEMS
PhylomeDBiQ54KM6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q54KM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNTVKRLM TYTFKPSKQT SSFGPSVWLE FSPLAIKYNA VNLGQGFPNF
60 70 80 90 100
EPPKFVKDAM IKTIEVGGFN QYTRSPGHIR LVKALSSVYS PYFGRELNAM
110 120 130 140 150
TEIMVGVGAS ESLFAAISSI VNEGDEVILI EPFFDIYIGP ILMAGGIPKF
160 170 180 190 200
VTLKEEESSQ AGSSDKKRSS KHWKINKEEL AAAFTDKTKL IILNNPHNPV
210 220 230 240 250
GKVYSKEELQ EIADVVAKHG PNTTVISDEV YEWMTFDGEE HHRFATLPGM
260 270 280 290 300
WERTITIGSA GKTFSITGWK VGWCIGPSNI IGAIANTHQY VPFSVPTPTQ
310 320 330 340 350
EAVAIALEQP NIKDYFKELA TMYQNKRDTL LNSLTQAGLD PVIPQGTYFI
360 370 380 390 400
MGDTSSIHLQ GDQGKDTSIT GMGLHLRDWN IARYLTTEYG VTTIPPSAFY
410 420 430
CDDHQKIPEN FVRFTFCKDD LTLQKAHDNL LKLKK
Length:435
Mass (Da):48,553
Last modified:May 24, 2005 - v1
Checksum:i5E86530007DCB3F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000099 Genomic DNA Translation: EAL63836.1
RefSeqiXP_637331.1, XM_632239.1

Genome annotation databases

EnsemblProtistsiEAL63836; EAL63836; DDB_G0287269
GeneIDi8626029
KEGGiddi:DDB_G0287269

Similar proteinsi

Entry informationi

Entry nameiKAT_DICDI
AccessioniPrimary (citable) accession number: Q54KM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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