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Protein

WD repeat-containing protein 5 homolog

Gene

wdr5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DDI-3214841 PKMTs methylate histone lysines
R-DDI-3214858 RMTs methylate histone arginines
R-DDI-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 5 homolog
Gene namesi
Name:wdr5
ORF Names:DDB_G0287273
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287273 wdr5

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276081 – 335WD repeat-containing protein 5 homologAdd BLAST335

Proteomic databases

PaxDbiQ54KL5
PRIDEiQ54KL5

Interactioni

Subunit structurei

May interact with the histone-lysine N-methyltransferase complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0232948

Structurei

3D structure databases

ProteinModelPortaliQ54KL5
SMRiQ54KL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 83WD 1Add BLAST40
Repeati86 – 127WD 2Add BLAST42
Repeati129 – 167WD 3Add BLAST39
Repeati170 – 209WD 4Add BLAST40
Repeati213 – 252WD 5Add BLAST40
Repeati256 – 298WD 6Add BLAST43
Repeati301 – 335WD 7Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 13Poly-Ser7
Compositional biasi17 – 26Poly-Gln10

Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
InParanoidiQ54KL5
KOiK14963
OMAiDNPICSH
PhylomeDBiQ54KL5

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037834 WDR5
PANTHERiPTHR22847:SF560 PTHR22847:SF560, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q54KL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGPASMSS SSSYLYQEQQ QQQPQQTESI PQTPNYILKY TLKGHLKSIS
60 70 80 90 100
SVKFSPDGKW LASASADKTI KIWGAYDGKF ERTLEGHKEG ISDIAWSQDS
110 120 130 140 150
KLICSASDDK TIKIWDVESG KMVKTLKGHK EYVFGVSFNP QSNLIVSGSF
160 170 180 190 200
DENVRIWDVN TGECTKMISA HSDPVTGVHF NRDGTLVVSG SYDGTVRIWD
210 220 230 240 250
TTTGQLLNTI STEDGKEVSF VKFSPNGKFV LAGTLDNTLR LWSYNNNKKC
260 270 280 290 300
LKTYTGHKNE KYCIFSTFSV TCGKWIVTGS EDNLIYIYNL QTREIVQTLA
310 320 330
GHEDVVLTVA CHPTENIIAS GALEKDRSVK IWKHM
Length:335
Mass (Da):37,370
Last modified:May 24, 2005 - v1
Checksum:iA32D14454FFF76AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000099 Genomic DNA Translation: EAL63798.1
RefSeqiXP_637302.1, XM_632210.1

Genome annotation databases

EnsemblProtistsiEAL63798; EAL63798; DDB_G0287273
GeneIDi8626039
KEGGiddi:DDB_G0287273

Similar proteinsi

Entry informationi

Entry nameiWDR5_DICDI
AccessioniPrimary (citable) accession number: Q54KL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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