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Protein

WD repeat-containing protein 5 homolog

Gene

wdr5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 5 homolog
Gene namesi
Name:wdr5
ORF Names:DDB_G0287273
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287273. wdr5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335WD repeat-containing protein 5 homologPRO_0000327608Add
BLAST

Proteomic databases

PaxDbiQ54KL5.
PRIDEiQ54KL5.

Interactioni

Subunit structurei

May interact with the histone-lysine N-methyltransferase complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0232948.

Structurei

3D structure databases

ProteinModelPortaliQ54KL5.
SMRiQ54KL5. Positions 20-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 8340WD 1Add
BLAST
Repeati86 – 12742WD 2Add
BLAST
Repeati129 – 16739WD 3Add
BLAST
Repeati170 – 20940WD 4Add
BLAST
Repeati213 – 25240WD 5Add
BLAST
Repeati256 – 29843WD 6Add
BLAST
Repeati301 – 33535WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 137Poly-Ser
Compositional biasi17 – 2610Poly-Gln

Sequence similaritiesi

Belongs to the WD repeat WDR5/wds family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
InParanoidiQ54KL5.
KOiK14963.
OMAiCIKTLPA.
PhylomeDBiQ54KL5.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54KL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGPASMSS SSSYLYQEQQ QQQPQQTESI PQTPNYILKY TLKGHLKSIS
60 70 80 90 100
SVKFSPDGKW LASASADKTI KIWGAYDGKF ERTLEGHKEG ISDIAWSQDS
110 120 130 140 150
KLICSASDDK TIKIWDVESG KMVKTLKGHK EYVFGVSFNP QSNLIVSGSF
160 170 180 190 200
DENVRIWDVN TGECTKMISA HSDPVTGVHF NRDGTLVVSG SYDGTVRIWD
210 220 230 240 250
TTTGQLLNTI STEDGKEVSF VKFSPNGKFV LAGTLDNTLR LWSYNNNKKC
260 270 280 290 300
LKTYTGHKNE KYCIFSTFSV TCGKWIVTGS EDNLIYIYNL QTREIVQTLA
310 320 330
GHEDVVLTVA CHPTENIIAS GALEKDRSVK IWKHM
Length:335
Mass (Da):37,370
Last modified:May 24, 2005 - v1
Checksum:iA32D14454FFF76AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000099 Genomic DNA. Translation: EAL63798.1.
RefSeqiXP_637302.1. XM_632210.1.

Genome annotation databases

EnsemblProtistsiDDB0232948; DDB0232948; DDB_G0287273.
GeneIDi8626039.
KEGGiddi:DDB_G0287273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000099 Genomic DNA. Translation: EAL63798.1.
RefSeqiXP_637302.1. XM_632210.1.

3D structure databases

ProteinModelPortaliQ54KL5.
SMRiQ54KL5. Positions 20-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232948.

Proteomic databases

PaxDbiQ54KL5.
PRIDEiQ54KL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0232948; DDB0232948; DDB_G0287273.
GeneIDi8626039.
KEGGiddi:DDB_G0287273.

Organism-specific databases

dictyBaseiDDB_G0287273. wdr5.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
InParanoidiQ54KL5.
KOiK14963.
OMAiCIKTLPA.
PhylomeDBiQ54KL5.

Miscellaneous databases

PROiQ54KL5.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiWDR5_DICDI
AccessioniPrimary (citable) accession number: Q54KL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: December 9, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.