Q54KI3 (ANM5_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein arginine N-methyltransferase 5
EC=2.1.1.-
EC=2.1.1.125

Gene names

Name:	prmt5
ORF Names:	DDB_G0287327

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	642 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methylates arginine residues in proteins such as small nuclear ribonucleoproteins or histone H2A/H4 By similarity.
Catalytic activity	S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW sorocarp development Inferred from mutant phenotype. Source: dictyBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	histone-arginine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 642	642	Protein arginine N-methyltransferase 5		PRO_0000330892
Regions
	Compositional bias	590 – 600	11	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q54KI3 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: C616E64BF172BF10	FASTA	642	73,499
	10 20 30 40 50 60 MINSAQYEFS CGVELESVDI QLDIERAYDL EYQFIMTSIS HPRFNRDFTK ASIGNSFSNK 70 80 90 100 110 120 VAFTRSDTLL QSNYWRSSIV GKTSTNGIDL DSIDPTIRSN SVKTLKQEIS WAAHLSLPSI 130 140 150 160 170 180 LLPTPSFNST NYAQVVNQSL QSLSYMKVWI RIPLVSPKSQ LLNKFDYYQD HNTSGGSGNN 190 200 210 220 230 240 LVDNDNPWEW WNNFRLLCNQ HPNLSAVLEM TSDLPSKEQL QQWLGEPVKC VIIPTSVFLT 250 260 270 280 290 300 NKAGFPTLSK AHQQFLLQLF NYNIQFVVSG ASMDTLKDYK TYLKFLHTNQ NPLTQEEYFE 310 320 330 340 350 360 MPYLDFLQAP LQPLMDNLES QTYEVFEKDP IKYKQYQNAV RLALLDLDKK DSKDDPIIIM 370 380 390 400 410 420 VVGAGRGPLV NSSIQASIEA NKFVKVFAVE KNPNAIVTLR NRIIMEGWEE IVTVIDSDMR 430 440 450 460 470 480 DWNTEYRADI MVSELLGSFG DNELSPECLD GAQRYLKKDT GISIPTWYTS YIAPISSSKL 490 500 510 520 530 540 FNEVTAYGDL KHSETPYVVK PHNFHQLAES KPLFTFSHPN RDEIIDNSRY ESLEFELTIP 550 560 570 580 590 600 STTCHGFIGY FDCCLYKDVH ISINPSNFST GMFSWFPIYF PLKQPVYFSN GNLNNNNNNN 610 620 630 640 IKAKCAFWRN VSKSKVWYEW CLLSPTITPI QNVGGRSYYI GL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000100 Genomic DNA. Translation: EAL63731.1.
RefSeq	XP_637240.1. XM_632148.1.
3D structure databases
ProteinModelPortal	Q54KI3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54KI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0235403; DDB0235403; DDB_G0287327.
GeneID	8626071.
GenomeReviews	Gene locus prmt5 in contig CM000154_GR.
KEGG	ddi:DDB_G0287327.
Organism-specific databases
dictyBase	DDB_G0287327. prmt5.
Phylogenomic databases
eggNOG	KOG0822.
GeneTree	EPrGT00050000000974.
HOGENOM	HBG628479.
OMA	LCDYNKR.
PhylomeDB	Q54KI3.
ProtClustDB	CLSZ2846455.
Family and domain databases
InterPro	IPR007857. Skb1_MeTrfase. [Graphical view]
KO	K02516.
PANTHER	PTHR10738. Skb1_mtfrase. 1 hit.
Pfam	PF05185. PRMT5. 1 hit. [Graphical view]
PIRSF	PIRSF015894. Skb1_MeTrfase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ANM5_DICDI

Accession

Primary (citable) accession number: Q54KI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)