Q54KG7 (ADRO_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
Short name=AR
Short name=Adrenodoxin reductase
EC=1.18.1.2

Alternative name(s):
Ferredoxin--NADP(+) reductase
Short name=Ferredoxin reductase

Gene names

Name:	fdxr
ORF Names:	DDB_G0287353

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.
Cofactor	FAD By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 1 family.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred by curator. Source: dictyBase transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from sequence or structural similarity. Source: dictyBase mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH-adrenodoxin reductase activity Inferred from sequence or structural similarity. Source: dictyBase ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 515		Probable NADPH:adrenodoxin oxidoreductase, mitochondrial		PRO_0000331233
Regions
	Nucleotide binding	191 – 194	4	NADP By similarity
	Nucleotide binding	236 – 237	2	NADP By similarity
	Nucleotide binding	426 – 428	3	FAD By similarity
	Compositional bias	453 – 458	6	Poly-Asn
Sites
	Binding site	52	1	FAD; via amide nitrogen By similarity
	Binding site	73	1	FAD By similarity
	Binding site	81	1	FAD; via amide nitrogen By similarity
	Binding site	248	1	NADP By similarity
	Binding site	419	1	FAD; via amide nitrogen By similarity
	Binding site	426	1	NADP; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54KG7 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 354F5110BB53F2D9	FASTA	515	57,701
	10 20 30 40 50 60 MINVLINKSS KLVNGVDSCI NNKTIRLFCS SSSTNQVNKT PFNLCIIGSG PAGLYTAAKV 70 80 90 100 110 120 HRQIPHANIT ILEKLPYPFG LVRSGISPDH QNEKKVKNTL EKVLLEHPHQ IQFIGNVDIE 130 140 150 160 170 180 KDIKFQYIKD NFHAVVLACG IEGDKKLGIP GELTLKNVYF AREFIGWLNG NLKDQHKQFD 190 200 210 220 230 240 LSNENLAIVG QGNVALDVAR LLLKKNSDEL KKTDITSTSF DKINKSNVKN IHIIGRRGPL 250 260 270 280 290 300 EVSFTNKEIR EILTLQNVNT FINDISTLDV SEEDVSKLER AKKRTFELFK QHLKPFDQEI 310 320 330 340 350 360 ANNGNMNLIF HFLRSPVELL DKYGSSSGSG DGMVLSKIKL EKNKLIIDEK TQQKKAIGSG 370 380 390 400 410 420 EFEIIECSSL FRSIGYTGTK QFPSVPFDFN SVSIPNKYGK VLEEPNSDKF INGLYVSGWL 430 440 450 460 470 480 KGGPSGSIPN ISANSEETAS IIHQDYESNQ FINNNNNNDG GHNSITSLLQ PNHKIINFND 490 500 510 YKKIESEEVK RGKEKGKLLE KIIVFDELKN IINNS

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000100 Genomic DNA. Translation: EAL63744.1.
RefSeq	XP_637256.1. XM_632164.1.
3D structure databases
HSSP	HSSP built from PDB template 1CJC based on UniProtKB P08165.
ProteinModelPortal	Q54KG7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54KG7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0234047; DDB0234047; DDB_G0287353.
GeneID	8626086.
GenomeReviews	Gene locus fdxr in contig CM000154_GR.
KEGG	ddi:DDB_G0287353.
Organism-specific databases
dictyBase	DDB_G0287353. fdxr.
Phylogenomic databases
eggNOG	KOG1800.
GeneTree	EPrGT00050000004774.
HOGENOM	HBG522200.
OMA	YHAVLLT.
PhylomeDB	Q54KG7.
ProtClustDB	CLSZ2430005.
Family and domain databases
InterPro	IPR021163. Adrenodoxin_Rdtase. IPR016040. NAD(P)-bd_dom. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00528.
Pfam	PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PIRSF	PIRSF000362. FNR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADRO_DICDI

Accession

Primary (citable) accession number: Q54KG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)