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Protein

Tyrosine aminotransferase

Gene

tat

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Has much lower affinity and transaminase activity towards phenylalanine (By similarity).By similarity

Catalytic activityi

L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.

Cofactori

Pathwayi: L-phenylalanine degradation

This protein is involved in step 2 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (pah)
  2. Tyrosine aminotransferase (tat)
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hgd)
  5. Maleylacetoacetate isomerase (mai)
  6. Fumarylacetoacetase (fah)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-71182 Phenylalanine and tyrosine catabolism
UniPathwayiUPA00139; UER00338

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine aminotransferase (EC:2.6.1.5)
Short name:
TAT
Alternative name(s):
L-tyrosine:2-oxoglutarate aminotransferase
Gene namesi
Name:tat
ORF Names:DDB_G0287515
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287515 tat

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276511 – 417Tyrosine aminotransferaseAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ54K95

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230996

Structurei

3D structure databases

ProteinModelPortaliQ54K95
SMRiQ54K95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0259 Eukaryota
COG0436 LUCA
InParanoidiQ54K95
KOiK00815
OMAiFRVVITV
PhylomeDBiQ54K95

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR005958 TyrNic_aminoTrfase
IPR005957 Tyrosine_aminoTrfase
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PIRSFiPIRSF000517 Tyr_transaminase, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01264 tyr_amTase_E, 1 hit
TIGR01265 tyr_nico_aTase, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q54K95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDNVSQRKW NVESSKSANN AFNPIRRIVD KGGFKPNPNK STISLSIGDP
60 70 80 90 100
CVFGNLNILD YANDLLIENI KSSKFNGYPP STGYEIAREA VAKYVETPTS
110 120 130 140 150
KLTSKDIIVA SGASGAIELA IGVLLNEGDN ILVPKPGFPL YECTSKTKFI
160 170 180 190 200
NVKHYNLLEK QGFNVDLEHL RSLIDDKTKA ILVNNPSNPC GIVYSKQHLL
210 220 230 240 250
DIIQVAREYC LPIIADEIYS DLTFGEHKFY PMASLTDKVP ILSIGGIAKR
260 270 280 290 300
FLVPGWRLGW VAIHDRDNIF SNGRIIEGLI SLSQVILGPN SLVQSILPKL
310 320 330 340 350
LDPQNTQVKE WCSTITKTLE SHSKLTVDML SKANGLKPVC SSGTMYQMIE
360 370 380 390 400
IDCSKYEDIA DDNEFVGKLL EEQSVFLLQG TVFSLPNFFR IVFCAPIDKL
410
TEAYERIIEF CETHKKK
Length:417
Mass (Da):46,485
Last modified:May 24, 2005 - v1
Checksum:i4B59356CCB02E941
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA Translation: EAL63657.1
RefSeqiXP_637160.1, XM_632068.1

Genome annotation databases

EnsemblProtistsiEAL63657; EAL63657; DDB_G0287515
GeneIDi8626161
KEGGiddi:DDB_G0287515

Similar proteinsi

Entry informationi

Entry nameiATTY_DICDI
AccessioniPrimary (citable) accession number: Q54K95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health