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Protein

Tyrosine aminotransferase

Gene

tat

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Has much lower affinity and transaminase activity towards phenylalanine (By similarity).By similarity

Catalytic activityi

L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.

Cofactori

Pathwayi: L-phenylalanine degradation

This protein is involved in step 2 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (pah)
  2. Tyrosine aminotransferase (tat)
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hgd)
  5. Maleylacetoacetate isomerase (mai)
  6. Fumarylacetoacetase (fah)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-71182. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00338.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine aminotransferase (EC:2.6.1.5)
Short name:
TAT
Alternative name(s):
L-tyrosine:2-oxoglutarate aminotransferase
Gene namesi
Name:tat
ORF Names:DDB_G0287515
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287515. tat.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Tyrosine aminotransferasePRO_0000327651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ54K95.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230996.

Structurei

3D structure databases

ProteinModelPortaliQ54K95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0259. Eukaryota.
COG0436. LUCA.
InParanoidiQ54K95.
KOiK00815.
OMAiEDDQDFC.
PhylomeDBiQ54K95.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR005958. TyrNic_aminoTrfase.
IPR005957. Tyrosine_aminoTrfase.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000517. Tyr_transaminase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01264. tyr_amTase_E. 1 hit.
TIGR01265. tyr_nico_aTase. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54K95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDNVSQRKW NVESSKSANN AFNPIRRIVD KGGFKPNPNK STISLSIGDP
60 70 80 90 100
CVFGNLNILD YANDLLIENI KSSKFNGYPP STGYEIAREA VAKYVETPTS
110 120 130 140 150
KLTSKDIIVA SGASGAIELA IGVLLNEGDN ILVPKPGFPL YECTSKTKFI
160 170 180 190 200
NVKHYNLLEK QGFNVDLEHL RSLIDDKTKA ILVNNPSNPC GIVYSKQHLL
210 220 230 240 250
DIIQVAREYC LPIIADEIYS DLTFGEHKFY PMASLTDKVP ILSIGGIAKR
260 270 280 290 300
FLVPGWRLGW VAIHDRDNIF SNGRIIEGLI SLSQVILGPN SLVQSILPKL
310 320 330 340 350
LDPQNTQVKE WCSTITKTLE SHSKLTVDML SKANGLKPVC SSGTMYQMIE
360 370 380 390 400
IDCSKYEDIA DDNEFVGKLL EEQSVFLLQG TVFSLPNFFR IVFCAPIDKL
410
TEAYERIIEF CETHKKK
Length:417
Mass (Da):46,485
Last modified:May 24, 2005 - v1
Checksum:i4B59356CCB02E941
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63657.1.
RefSeqiXP_637160.1. XM_632068.1.

Genome annotation databases

EnsemblProtistsiDDB0230996; DDB0230996; DDB_G0287515.
GeneIDi8626161.
KEGGiddi:DDB_G0287515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63657.1.
RefSeqiXP_637160.1. XM_632068.1.

3D structure databases

ProteinModelPortaliQ54K95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0230996.

Proteomic databases

PaxDbiQ54K95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0230996; DDB0230996; DDB_G0287515.
GeneIDi8626161.
KEGGiddi:DDB_G0287515.

Organism-specific databases

dictyBaseiDDB_G0287515. tat.

Phylogenomic databases

eggNOGiKOG0259. Eukaryota.
COG0436. LUCA.
InParanoidiQ54K95.
KOiK00815.
OMAiEDDQDFC.
PhylomeDBiQ54K95.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00338.
ReactomeiR-DDI-71182. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

PROiQ54K95.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR005958. TyrNic_aminoTrfase.
IPR005957. Tyrosine_aminoTrfase.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000517. Tyr_transaminase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01264. tyr_amTase_E. 1 hit.
TIGR01265. tyr_nico_aTase. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATTY_DICDI
AccessioniPrimary (citable) accession number: Q54K95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: December 9, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.