Reviewed, UniProtKB/Swiss-Prot Q54K91 (ACH1_DICDI)

Names and origin

Protein names

Recommended name:
    Acetyl-CoA hydrolase
    EC=3.1.2.1
Alternative name(s):
    Acetyl-CoA deacylase
      Short name=Acetyl-CoA acylase

Gene names

Name:	ach1
ORF Names:	DDB_G0287519

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 532	532	Acetyl-CoA hydrolase		PRO_0000330918

Sequences

	Sequence		Length	Mass (Da)
	Q54K91-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: BA70191A19871714	FASTA	532	58,894
	10 20 30 40 50 60 MHKIVQQGSK SLIESRIKRK SLLSKVVTDV SQLIPYFQNG HYVSMGGFAG TGYPKVVPIA 70 80 90 100 110 120 LADHVEKNGL QGKLKMNLFV GASVGPETED RWAMLDMIDK RYPHQNGHHI RNGINSGRIR 130 140 150 160 170 180 FADQHLSTFA SDLLAGYYTL DKPHGSKRTM DIAIVEATEI TEDGCIVPGA SVGITPEILQ 190 200 210 220 230 240 MADKIIIEIN TSLPSFKGLH DMVKIALPPF SKPYQITRVD DRIGLEAFPV DPEKIIAIVE 250 260 270 280 290 300 SQLPDNTSVG APEDETSSAI ANNIVQFFIH EIEQGRFPKN LLPLQSGIGS IANAVIGGLS 310 320 330 340 350 360 KGPFDNLSVW TEVIQDTFLD FFDNGKLKFA SATSLRFSPP GFNRLFNNWE NYKSKIILRN 370 380 390 400 410 420 QAISNAAELI SRVGCIALNT PCEVDIYGHV NSTNTMGSKM LNGLGGSGEF LRNSRISIVH 430 440 450 460 470 480 TPSTRPTKTD PHGISCIVPF ASHIDHTEHD IDIIVTEQGL ADIRGLAPYE RAKVIIQNCA 490 500 510 520 530 HPIYKPILME YLETSRQICL KNHMGHEPHQ LDKAFKFYTN LSEKGTMKID KW

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000102 Genomic DNA. Translation: EAL63659.1.
RefSeq	XP_637164.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54K91.
Genome annotation databases
GeneID	3388763.
GenomeReviews	Gene locus ach1 in contig CM000154_GR.
KEGG	ddi:DDB_0233380.
Organism-specific databases
dictyBase	DDB_G0287519. ach1.
Phylogenomic databases
OMA	DEALSWH.
Family and domain databases
InterPro	IPR003702. ActCoA_hydro. [Graphical view]
PANTHER	PTHR21432. ActCoA_hydro. 1 hit.
Pfam	PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_DICDI

Accession

Primary (citable) accession number: Q54K91

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)