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Protein

Acetyl-CoA hydrolase

Gene

ach1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3125-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei402Coenzyme ABy similarity1
Binding sitei406Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ach1
ORF Names:DDB_G0287519
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287519

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003309181 – 532Acetyl-CoA hydrolaseAdd BLAST532

Proteomic databases

PaxDbiQ54K91

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0233380

Structurei

3D structure databases

ProteinModelPortaliQ54K91
SMRiQ54K91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni287 – 291Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2828 Eukaryota
COG0427 LUCA
InParanoidiQ54K91
KOiK01067
OMAiDEALSWH
PhylomeDBiQ54K91

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
InterProiView protein in InterPro
IPR026888 AcetylCoA_hyd_C
IPR038460 AcetylCoA_hyd_C_sf
IPR003702 ActCoA_hydro
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF13336 AcetylCoA_hyd_C, 1 hit
PF02550 AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits

Sequencei

Sequence statusi: Complete.

Q54K91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKIVQQGSK SLIESRIKRK SLLSKVVTDV SQLIPYFQNG HYVSMGGFAG
60 70 80 90 100
TGYPKVVPIA LADHVEKNGL QGKLKMNLFV GASVGPETED RWAMLDMIDK
110 120 130 140 150
RYPHQNGHHI RNGINSGRIR FADQHLSTFA SDLLAGYYTL DKPHGSKRTM
160 170 180 190 200
DIAIVEATEI TEDGCIVPGA SVGITPEILQ MADKIIIEIN TSLPSFKGLH
210 220 230 240 250
DMVKIALPPF SKPYQITRVD DRIGLEAFPV DPEKIIAIVE SQLPDNTSVG
260 270 280 290 300
APEDETSSAI ANNIVQFFIH EIEQGRFPKN LLPLQSGIGS IANAVIGGLS
310 320 330 340 350
KGPFDNLSVW TEVIQDTFLD FFDNGKLKFA SATSLRFSPP GFNRLFNNWE
360 370 380 390 400
NYKSKIILRN QAISNAAELI SRVGCIALNT PCEVDIYGHV NSTNTMGSKM
410 420 430 440 450
LNGLGGSGEF LRNSRISIVH TPSTRPTKTD PHGISCIVPF ASHIDHTEHD
460 470 480 490 500
IDIIVTEQGL ADIRGLAPYE RAKVIIQNCA HPIYKPILME YLETSRQICL
510 520 530
KNHMGHEPHQ LDKAFKFYTN LSEKGTMKID KW
Length:532
Mass (Da):58,894
Last modified:May 24, 2005 - v1
Checksum:iBA70191A19871714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA Translation: EAL63659.1
RefSeqiXP_637164.1, XM_632072.1

Genome annotation databases

EnsemblProtistsiEAL63659; EAL63659; DDB_G0287519
GeneIDi8626165
KEGGiddi:DDB_G0287519

Similar proteinsi

Entry informationi

Entry nameiACH1_DICDI
AccessioniPrimary (citable) accession number: Q54K91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health