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Q54K91

- ACH1_DICDI

UniProt

Q54K91 - ACH1_DICDI

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Protein

Acetyl-CoA hydrolase

Gene

ach1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei312 – 31215-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei402 – 4021Coenzyme ABy similarity
Binding sitei406 – 4061Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetyl-CoA hydrolase activity Source: dictyBase

GO - Biological processi

  1. acetyl-CoA metabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ach1
ORF Names:DDB_G0287519
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287519.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Acetyl-CoA hydrolasePRO_0000330918Add
BLAST

Proteomic databases

PRIDEiQ54K91.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0233380.

Structurei

3D structure databases

ProteinModelPortaliQ54K91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni287 – 2915Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
InParanoidiQ54K91.
KOiK01067.
OMAiPRFFENM.
PhylomeDBiQ54K91.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54K91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKIVQQGSK SLIESRIKRK SLLSKVVTDV SQLIPYFQNG HYVSMGGFAG
60 70 80 90 100
TGYPKVVPIA LADHVEKNGL QGKLKMNLFV GASVGPETED RWAMLDMIDK
110 120 130 140 150
RYPHQNGHHI RNGINSGRIR FADQHLSTFA SDLLAGYYTL DKPHGSKRTM
160 170 180 190 200
DIAIVEATEI TEDGCIVPGA SVGITPEILQ MADKIIIEIN TSLPSFKGLH
210 220 230 240 250
DMVKIALPPF SKPYQITRVD DRIGLEAFPV DPEKIIAIVE SQLPDNTSVG
260 270 280 290 300
APEDETSSAI ANNIVQFFIH EIEQGRFPKN LLPLQSGIGS IANAVIGGLS
310 320 330 340 350
KGPFDNLSVW TEVIQDTFLD FFDNGKLKFA SATSLRFSPP GFNRLFNNWE
360 370 380 390 400
NYKSKIILRN QAISNAAELI SRVGCIALNT PCEVDIYGHV NSTNTMGSKM
410 420 430 440 450
LNGLGGSGEF LRNSRISIVH TPSTRPTKTD PHGISCIVPF ASHIDHTEHD
460 470 480 490 500
IDIIVTEQGL ADIRGLAPYE RAKVIIQNCA HPIYKPILME YLETSRQICL
510 520 530
KNHMGHEPHQ LDKAFKFYTN LSEKGTMKID KW
Length:532
Mass (Da):58,894
Last modified:May 24, 2005 - v1
Checksum:iBA70191A19871714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63659.1.
RefSeqiXP_637164.1. XM_632072.1.

Genome annotation databases

EnsemblProtistsiDDB0233380; DDB0233380; DDB_G0287519.
GeneIDi8626165.
KEGGiddi:DDB_G0287519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63659.1 .
RefSeqi XP_637164.1. XM_632072.1.

3D structure databases

ProteinModelPortali Q54K91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233380.

Proteomic databases

PRIDEi Q54K91.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233380 ; DDB0233380 ; DDB_G0287519 .
GeneIDi 8626165.
KEGGi ddi:DDB_G0287519.

Organism-specific databases

dictyBasei DDB_G0287519.

Phylogenomic databases

eggNOGi COG0427.
InParanoidi Q54K91.
KOi K01067.
OMAi PRFFENM.
PhylomeDBi Q54K91.

Miscellaneous databases

PROi Q54K91.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiACH1_DICDI
AccessioniPrimary (citable) accession number: Q54K91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3