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Q54K91

- ACH1_DICDI

UniProt

Q54K91 - ACH1_DICDI

Protein

Acetyl-CoA hydrolase

Gene

ach1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O = CoA + acetate.

    GO - Molecular functioni

    1. acetyl-CoA hydrolase activity Source: dictyBase

    GO - Biological processi

    1. acetyl-CoA metabolic process Source: dictyBase

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA hydrolase (EC:3.1.2.1)
    Alternative name(s):
    Acetyl-CoA deacylase
    Short name:
    Acetyl-CoA acylase
    Gene namesi
    Name:ach1
    ORF Names:DDB_G0287519
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0287519.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Acetyl-CoA hydrolasePRO_0000330918Add
    BLAST

    Proteomic databases

    PRIDEiQ54K91.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0233380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54K91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0427.
    KOiK01067.
    OMAiPRFFENM.
    PhylomeDBiQ54K91.

    Family and domain databases

    InterProiIPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view]
    PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54K91-1 [UniParc]FASTAAdd to Basket

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    MHKIVQQGSK SLIESRIKRK SLLSKVVTDV SQLIPYFQNG HYVSMGGFAG    50
    TGYPKVVPIA LADHVEKNGL QGKLKMNLFV GASVGPETED RWAMLDMIDK 100
    RYPHQNGHHI RNGINSGRIR FADQHLSTFA SDLLAGYYTL DKPHGSKRTM 150
    DIAIVEATEI TEDGCIVPGA SVGITPEILQ MADKIIIEIN TSLPSFKGLH 200
    DMVKIALPPF SKPYQITRVD DRIGLEAFPV DPEKIIAIVE SQLPDNTSVG 250
    APEDETSSAI ANNIVQFFIH EIEQGRFPKN LLPLQSGIGS IANAVIGGLS 300
    KGPFDNLSVW TEVIQDTFLD FFDNGKLKFA SATSLRFSPP GFNRLFNNWE 350
    NYKSKIILRN QAISNAAELI SRVGCIALNT PCEVDIYGHV NSTNTMGSKM 400
    LNGLGGSGEF LRNSRISIVH TPSTRPTKTD PHGISCIVPF ASHIDHTEHD 450
    IDIIVTEQGL ADIRGLAPYE RAKVIIQNCA HPIYKPILME YLETSRQICL 500
    KNHMGHEPHQ LDKAFKFYTN LSEKGTMKID KW 532
    Length:532
    Mass (Da):58,894
    Last modified:May 24, 2005 - v1
    Checksum:iBA70191A19871714
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000102 Genomic DNA. Translation: EAL63659.1.
    RefSeqiXP_637164.1. XM_632072.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233380; DDB0233380; DDB_G0287519.
    GeneIDi8626165.
    KEGGiddi:DDB_G0287519.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000102 Genomic DNA. Translation: EAL63659.1 .
    RefSeqi XP_637164.1. XM_632072.1.

    3D structure databases

    ProteinModelPortali Q54K91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0233380.

    Proteomic databases

    PRIDEi Q54K91.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233380 ; DDB0233380 ; DDB_G0287519 .
    GeneIDi 8626165.
    KEGGi ddi:DDB_G0287519.

    Organism-specific databases

    dictyBasei DDB_G0287519.

    Phylogenomic databases

    eggNOGi COG0427.
    KOi K01067.
    OMAi PRFFENM.
    PhylomeDBi Q54K91.

    Miscellaneous databases

    PROi Q54K91.

    Family and domain databases

    InterProi IPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view ]
    Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiACH1_DICDI
    AccessioniPrimary (citable) accession number: Q54K91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3