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Q54K67

- MANG_DICDI

UniProt

Q54K67 - MANG_DICDI

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Protein

Alpha-mannosidase G

Gene

manG

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641ZincBy similarity
Metal bindingi266 – 2661ZincBy similarity
Active sitei376 – 3761NucleophileBy similarity
Metal bindingi376 – 3761ZincBy similarity
Metal bindingi579 – 5791ZincBy similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase G (EC:3.2.1.24)
Gene namesi
Name:manG
ORF Names:DDB_G0287577
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287577. manG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10871087Alpha-mannosidase GPRO_0000327486Add
BLAST

Proteomic databases

PRIDEiQ54K67.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231611.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi628 – 64114Poly-ThrAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Phylogenomic databases

eggNOGiCOG0383.
InParanoidiQ54K67.
KOiK01191.
OMAiKSANPRN.
PhylomeDBiQ54K67.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54K67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSGNVMLKH QDVTIERIEK FLSDTYFVRE NLYGKLISLK SSEAVKVKVS
60 70 80 90 100
PKVEGISYKD AIQLEYKDTK IGESFGPSWT NYWFKVTIDV PTDWKDKTIH
110 120 130 140 150
FIWNSSCEGL IWMNGIAIQG LIGGTWQDLR EEYKLIENSK GGEHFEFYIE
160 170 180 190 200
ISCNGMFGVG KDGLINPCDP DRTFELTKAE IRVKNKEANE LYMYLQMLYD
210 220 230 240 250
VGKNFPKESL RKKQAIWVAN DIINQCNVND SRTFSKCIEL AKKEFFSQHN
260 270 280 290 300
SESQTRVWAV GHCHIDLCWL WSFEKTKEKC ARSFSTQILY MDYYPQFKFT
310 320 330 340 350
QSQAQAYQWT KENYPELYER IKEKVVTGQF IPTGGTWVEM DGNLPSGESF
360 370 380 390 400
IRQFLYGQRF FEKEFGKKCT EFFLPDTFGY SAQLPQVIRH MGIENFITQK
410 420 430 440 450
LSWNNLNKFP HSTFIWEGID GSSVLTHFPP ADTYNSQADV KEIVMSSSNN
460 470 480 490 500
KDIDRCNESM LLYGNGDGGG GPTIPMIERL TILKDTAGIP KIEFSTPAQF
510 520 530 540 550
FKQLEPHRSK LNKWVGELYF ELHRGTYTSQ ATTKRGNRLC EIELHATEML
560 570 580 590 600
TSYCELFVEG FKSPNLSKLW QQVLLCQFHD ALPGSSIQVC YEDILKIHQQ
610 620 630 640 650
VLVECKNIIT QSMNHITGTL LKIDNLPTTS TTTSTTTTST TECTKNSEFV
660 670 680 690 700
LAFNANDFEI SRVIEIPKSN KDIQAQYINA IQTSYNGLPL GTVSLPPNGF
710 720 730 740 750
SAINISTSGD NRTINRKPGY PCTAIEKNDA SGDILIDNQF ISIVIGSNGR
760 770 780 790 800
IKSLIEKSAN REVIKQDGSL GNRLIIFDDT CLFWDAWDQE IFSLEKPLSI
810 820 830 840 850
LEGTCKIIEN GPLRCVVQVH YDSKGLPSGN GSVNQTIIVH FNSARVDFET
860 870 880 890 900
NVNWNEAHKL LRVDFDTNIR AKNANYEIQF GHIERPTHYN TSWDFARFEV
910 920 930 940 950
VGHKWADLSE YDFGMALLND CKYGYSTLGG RIGLSLLRSP KSPDDTCDMG
960 970 980 990 1000
SHKFTYSIYP HRGSLQSASV IKEGYSLNNN FYISETPFSL ASTTHIDKTF
1010 1020 1030 1040 1050
ISTNKEAIIV DTIKKAEDGT SFVVRVYESF GGATTFNFTS SILPIPFKSI
1060 1070 1080
IECNGLEEVN QSSKSYKFND TIKINPFEIK TFRFISN
Length:1,087
Mass (Da):123,691
Last modified:May 24, 2005 - v1
Checksum:i32E15E3EA33F6CAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63688.1.
RefSeqiXP_637188.1. XM_632096.1.

Genome annotation databases

EnsemblProtistsiDDB0231611; DDB0231611; DDB_G0287577.
GeneIDi8626190.
KEGGiddi:DDB_G0287577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63688.1 .
RefSeqi XP_637188.1. XM_632096.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231611.

Proteomic databases

PRIDEi Q54K67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231611 ; DDB0231611 ; DDB_G0287577 .
GeneIDi 8626190.
KEGGi ddi:DDB_G0287577.

Organism-specific databases

dictyBasei DDB_G0287577. manG.

Phylogenomic databases

eggNOGi COG0383.
InParanoidi Q54K67.
KOi K01191.
OMAi KSANPRN.
PhylomeDBi Q54K67.

Miscellaneous databases

PROi Q54K67.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. Bienvenut W.V., Ura S., Insall R.H.
    Submitted (JUL-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 863-870 AND 932-938, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: AX2.

Entry informationi

Entry nameiMANG_DICDI
AccessioniPrimary (citable) accession number: Q54K67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3