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Q54K67

- MANG_DICDI

UniProt

Q54K67 - MANG_DICDI

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Protein

Alpha-mannosidase G

Gene
manG, DDB_G0287577
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641Zinc By similarity
Metal bindingi266 – 2661Zinc By similarity
Active sitei376 – 3761Nucleophile By similarity
Metal bindingi376 – 3761Zinc By similarity
Metal bindingi579 – 5791Zinc By similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase G (EC:3.2.1.24)
Gene namesi
Name:manG
ORF Names:DDB_G0287577
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287577. manG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10871087Alpha-mannosidase GPRO_0000327486Add
BLAST

Proteomic databases

PRIDEiQ54K67.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231611.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi628 – 64114Poly-ThrAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0383.
KOiK01191.
OMAiKSANPRN.
PhylomeDBiQ54K67.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54K67-1 [UniParc]FASTAAdd to Basket

« Hide

MTSGNVMLKH QDVTIERIEK FLSDTYFVRE NLYGKLISLK SSEAVKVKVS     50
PKVEGISYKD AIQLEYKDTK IGESFGPSWT NYWFKVTIDV PTDWKDKTIH 100
FIWNSSCEGL IWMNGIAIQG LIGGTWQDLR EEYKLIENSK GGEHFEFYIE 150
ISCNGMFGVG KDGLINPCDP DRTFELTKAE IRVKNKEANE LYMYLQMLYD 200
VGKNFPKESL RKKQAIWVAN DIINQCNVND SRTFSKCIEL AKKEFFSQHN 250
SESQTRVWAV GHCHIDLCWL WSFEKTKEKC ARSFSTQILY MDYYPQFKFT 300
QSQAQAYQWT KENYPELYER IKEKVVTGQF IPTGGTWVEM DGNLPSGESF 350
IRQFLYGQRF FEKEFGKKCT EFFLPDTFGY SAQLPQVIRH MGIENFITQK 400
LSWNNLNKFP HSTFIWEGID GSSVLTHFPP ADTYNSQADV KEIVMSSSNN 450
KDIDRCNESM LLYGNGDGGG GPTIPMIERL TILKDTAGIP KIEFSTPAQF 500
FKQLEPHRSK LNKWVGELYF ELHRGTYTSQ ATTKRGNRLC EIELHATEML 550
TSYCELFVEG FKSPNLSKLW QQVLLCQFHD ALPGSSIQVC YEDILKIHQQ 600
VLVECKNIIT QSMNHITGTL LKIDNLPTTS TTTSTTTTST TECTKNSEFV 650
LAFNANDFEI SRVIEIPKSN KDIQAQYINA IQTSYNGLPL GTVSLPPNGF 700
SAINISTSGD NRTINRKPGY PCTAIEKNDA SGDILIDNQF ISIVIGSNGR 750
IKSLIEKSAN REVIKQDGSL GNRLIIFDDT CLFWDAWDQE IFSLEKPLSI 800
LEGTCKIIEN GPLRCVVQVH YDSKGLPSGN GSVNQTIIVH FNSARVDFET 850
NVNWNEAHKL LRVDFDTNIR AKNANYEIQF GHIERPTHYN TSWDFARFEV 900
VGHKWADLSE YDFGMALLND CKYGYSTLGG RIGLSLLRSP KSPDDTCDMG 950
SHKFTYSIYP HRGSLQSASV IKEGYSLNNN FYISETPFSL ASTTHIDKTF 1000
ISTNKEAIIV DTIKKAEDGT SFVVRVYESF GGATTFNFTS SILPIPFKSI 1050
IECNGLEEVN QSSKSYKFND TIKINPFEIK TFRFISN 1087
Length:1,087
Mass (Da):123,691
Last modified:May 24, 2005 - v1
Checksum:i32E15E3EA33F6CAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63688.1.
RefSeqiXP_637188.1. XM_632096.1.

Genome annotation databases

EnsemblProtistsiDDB0231611; DDB0231611; DDB_G0287577.
GeneIDi8626190.
KEGGiddi:DDB_G0287577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000102 Genomic DNA. Translation: EAL63688.1 .
RefSeqi XP_637188.1. XM_632096.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231611.

Proteomic databases

PRIDEi Q54K67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231611 ; DDB0231611 ; DDB_G0287577 .
GeneIDi 8626190.
KEGGi ddi:DDB_G0287577.

Organism-specific databases

dictyBasei DDB_G0287577. manG.

Phylogenomic databases

eggNOGi COG0383.
KOi K01191.
OMAi KSANPRN.
PhylomeDBi Q54K67.

Miscellaneous databases

PROi Q54K67.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. Bienvenut W.V., Ura S., Insall R.H.
    Submitted (JUL-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 863-870 AND 932-938, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: AX2.

Entry informationi

Entry nameiMANG_DICDI
AccessioniPrimary (citable) accession number: Q54K67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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