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Q54K67 (MANG_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-mannosidase G

EC=3.2.1.24
Gene names
Name:manG
ORF Names:DDB_G0287577
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1087 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 38 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10871087Alpha-mannosidase G
PRO_0000327486

Regions

Compositional bias628 – 64114Poly-Thr

Sites

Active site3761Nucleophile By similarity
Metal binding2641Zinc By similarity
Metal binding2661Zinc By similarity
Metal binding3761Zinc By similarity
Metal binding5791Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54K67 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 32E15E3EA33F6CAA

FASTA1,087123,691
        10         20         30         40         50         60 
MTSGNVMLKH QDVTIERIEK FLSDTYFVRE NLYGKLISLK SSEAVKVKVS PKVEGISYKD 

        70         80         90        100        110        120 
AIQLEYKDTK IGESFGPSWT NYWFKVTIDV PTDWKDKTIH FIWNSSCEGL IWMNGIAIQG 

       130        140        150        160        170        180 
LIGGTWQDLR EEYKLIENSK GGEHFEFYIE ISCNGMFGVG KDGLINPCDP DRTFELTKAE 

       190        200        210        220        230        240 
IRVKNKEANE LYMYLQMLYD VGKNFPKESL RKKQAIWVAN DIINQCNVND SRTFSKCIEL 

       250        260        270        280        290        300 
AKKEFFSQHN SESQTRVWAV GHCHIDLCWL WSFEKTKEKC ARSFSTQILY MDYYPQFKFT 

       310        320        330        340        350        360 
QSQAQAYQWT KENYPELYER IKEKVVTGQF IPTGGTWVEM DGNLPSGESF IRQFLYGQRF 

       370        380        390        400        410        420 
FEKEFGKKCT EFFLPDTFGY SAQLPQVIRH MGIENFITQK LSWNNLNKFP HSTFIWEGID 

       430        440        450        460        470        480 
GSSVLTHFPP ADTYNSQADV KEIVMSSSNN KDIDRCNESM LLYGNGDGGG GPTIPMIERL 

       490        500        510        520        530        540 
TILKDTAGIP KIEFSTPAQF FKQLEPHRSK LNKWVGELYF ELHRGTYTSQ ATTKRGNRLC 

       550        560        570        580        590        600 
EIELHATEML TSYCELFVEG FKSPNLSKLW QQVLLCQFHD ALPGSSIQVC YEDILKIHQQ 

       610        620        630        640        650        660 
VLVECKNIIT QSMNHITGTL LKIDNLPTTS TTTSTTTTST TECTKNSEFV LAFNANDFEI 

       670        680        690        700        710        720 
SRVIEIPKSN KDIQAQYINA IQTSYNGLPL GTVSLPPNGF SAINISTSGD NRTINRKPGY 

       730        740        750        760        770        780 
PCTAIEKNDA SGDILIDNQF ISIVIGSNGR IKSLIEKSAN REVIKQDGSL GNRLIIFDDT 

       790        800        810        820        830        840 
CLFWDAWDQE IFSLEKPLSI LEGTCKIIEN GPLRCVVQVH YDSKGLPSGN GSVNQTIIVH 

       850        860        870        880        890        900 
FNSARVDFET NVNWNEAHKL LRVDFDTNIR AKNANYEIQF GHIERPTHYN TSWDFARFEV 

       910        920        930        940        950        960 
VGHKWADLSE YDFGMALLND CKYGYSTLGG RIGLSLLRSP KSPDDTCDMG SHKFTYSIYP 

       970        980        990       1000       1010       1020 
HRGSLQSASV IKEGYSLNNN FYISETPFSL ASTTHIDKTF ISTNKEAIIV DTIKKAEDGT 

      1030       1040       1050       1060       1070       1080 
SFVVRVYESF GGATTFNFTS SILPIPFKSI IECNGLEEVN QSSKSYKFND TIKINPFEIK 


TFRFISN 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]Bienvenut W.V., Ura S., Insall R.H.
Submitted (JUL-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 863-870 AND 932-938, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: AX2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000102 Genomic DNA. Translation: EAL63688.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231611.

Proteomic databases

PRIDEQ54K67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231611; DDB0231611; DDB_G0287577.
KEGGddi:DDB_G0287577.

Organism-specific databases

dictyBaseDDB_G0287577. manG.

Phylogenomic databases

eggNOGCOG0383.
KOK01191.
OMAYSQRNFL.
PhylomeDBQ54K67.
ProtClustDBCLSZ2728867.

Family and domain databases

Gene3D1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
[Graphical view]
PfamPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMSSF74650. SSF74650. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetSearch...

Other

PROQ54K67.

Entry information

Entry nameMANG_DICDI
AccessionPrimary (citable) accession number: Q54K67
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase