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Q54K67

- MANG_DICDI

UniProt

Q54K67 - MANG_DICDI

Protein

Alpha-mannosidase G

Gene

manG

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi264 – 2641ZincBy similarity
    Metal bindingi266 – 2661ZincBy similarity
    Active sitei376 – 3761NucleophileBy similarity
    Metal bindingi376 – 3761ZincBy similarity
    Metal bindingi579 – 5791ZincBy similarity

    GO - Molecular functioni

    1. alpha-mannosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. mannose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-mannosidase G (EC:3.2.1.24)
    Gene namesi
    Name:manG
    ORF Names:DDB_G0287577
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0287577. manG.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10871087Alpha-mannosidase GPRO_0000327486Add
    BLAST

    Proteomic databases

    PRIDEiQ54K67.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231611.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi628 – 64114Poly-ThrAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 38 family.Curated

    Phylogenomic databases

    eggNOGiCOG0383.
    KOiK01191.
    OMAiKSANPRN.
    PhylomeDBiQ54K67.

    Family and domain databases

    Gene3Di1.20.1270.50. 1 hit.
    3.20.110.10. 1 hit.
    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view]
    PfamiPF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view]
    SMARTiSM00872. Alpha-mann_mid. 1 hit.
    [Graphical view]
    SUPFAMiSSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54K67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSGNVMLKH QDVTIERIEK FLSDTYFVRE NLYGKLISLK SSEAVKVKVS     50
    PKVEGISYKD AIQLEYKDTK IGESFGPSWT NYWFKVTIDV PTDWKDKTIH 100
    FIWNSSCEGL IWMNGIAIQG LIGGTWQDLR EEYKLIENSK GGEHFEFYIE 150
    ISCNGMFGVG KDGLINPCDP DRTFELTKAE IRVKNKEANE LYMYLQMLYD 200
    VGKNFPKESL RKKQAIWVAN DIINQCNVND SRTFSKCIEL AKKEFFSQHN 250
    SESQTRVWAV GHCHIDLCWL WSFEKTKEKC ARSFSTQILY MDYYPQFKFT 300
    QSQAQAYQWT KENYPELYER IKEKVVTGQF IPTGGTWVEM DGNLPSGESF 350
    IRQFLYGQRF FEKEFGKKCT EFFLPDTFGY SAQLPQVIRH MGIENFITQK 400
    LSWNNLNKFP HSTFIWEGID GSSVLTHFPP ADTYNSQADV KEIVMSSSNN 450
    KDIDRCNESM LLYGNGDGGG GPTIPMIERL TILKDTAGIP KIEFSTPAQF 500
    FKQLEPHRSK LNKWVGELYF ELHRGTYTSQ ATTKRGNRLC EIELHATEML 550
    TSYCELFVEG FKSPNLSKLW QQVLLCQFHD ALPGSSIQVC YEDILKIHQQ 600
    VLVECKNIIT QSMNHITGTL LKIDNLPTTS TTTSTTTTST TECTKNSEFV 650
    LAFNANDFEI SRVIEIPKSN KDIQAQYINA IQTSYNGLPL GTVSLPPNGF 700
    SAINISTSGD NRTINRKPGY PCTAIEKNDA SGDILIDNQF ISIVIGSNGR 750
    IKSLIEKSAN REVIKQDGSL GNRLIIFDDT CLFWDAWDQE IFSLEKPLSI 800
    LEGTCKIIEN GPLRCVVQVH YDSKGLPSGN GSVNQTIIVH FNSARVDFET 850
    NVNWNEAHKL LRVDFDTNIR AKNANYEIQF GHIERPTHYN TSWDFARFEV 900
    VGHKWADLSE YDFGMALLND CKYGYSTLGG RIGLSLLRSP KSPDDTCDMG 950
    SHKFTYSIYP HRGSLQSASV IKEGYSLNNN FYISETPFSL ASTTHIDKTF 1000
    ISTNKEAIIV DTIKKAEDGT SFVVRVYESF GGATTFNFTS SILPIPFKSI 1050
    IECNGLEEVN QSSKSYKFND TIKINPFEIK TFRFISN 1087
    Length:1,087
    Mass (Da):123,691
    Last modified:May 24, 2005 - v1
    Checksum:i32E15E3EA33F6CAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000102 Genomic DNA. Translation: EAL63688.1.
    RefSeqiXP_637188.1. XM_632096.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231611; DDB0231611; DDB_G0287577.
    GeneIDi8626190.
    KEGGiddi:DDB_G0287577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000102 Genomic DNA. Translation: EAL63688.1 .
    RefSeqi XP_637188.1. XM_632096.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231611.

    Proteomic databases

    PRIDEi Q54K67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231611 ; DDB0231611 ; DDB_G0287577 .
    GeneIDi 8626190.
    KEGGi ddi:DDB_G0287577.

    Organism-specific databases

    dictyBasei DDB_G0287577. manG.

    Phylogenomic databases

    eggNOGi COG0383.
    KOi K01191.
    OMAi KSANPRN.
    PhylomeDBi Q54K67.

    Miscellaneous databases

    PROi Q54K67.

    Family and domain databases

    Gene3Di 1.20.1270.50. 1 hit.
    3.20.110.10. 1 hit.
    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view ]
    Pfami PF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view ]
    SMARTi SM00872. Alpha-mann_mid. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. Bienvenut W.V., Ura S., Insall R.H.
      Submitted (JUL-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 863-870 AND 932-938, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: AX2.

    Entry informationi

    Entry nameiMANG_DICDI
    AccessioniPrimary (citable) accession number: Q54K67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3