Beta-hexosaminidase subunit B2 precursor - Dictyostelium discoideum (Slime mold)

Contribute

Read comments (?) or add your own

Q54K56 (HEXB2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Beta-hexosaminidase subunit B2
EC=3.2.1.52

Alternative name(s):
Beta-N-acetylhexosaminidase subunit B2
N-acetyl-beta-glucosaminidase subunit B2

Gene names

Name:	hexb2
ORF Names:	DDB_G0287659

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from direct assay PubMed 20422638. Source: dictyBase lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

19

Potential

Chain

545

Beta-hexosaminidase subunit B2

PRO_0000331238

Regions

Compositional bias

10

Poly-Ser

Sites

Active site

1

Proton donor By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q54K56 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 0C65D857428ABC9E
Show »

564

64,566

        10         20         30         40         50         60 
MKLKFIFLIL FFIIGNSIGI KISKEINKIK LNDISIDGEI LLNKSSDSSS SQSSKIINIW 

        70         80         90        100        110        120 
PMPKKVLNGD ITVYISPHFQ FTTNLTKSTT LKKAMDRYYK LIFTEDSKSH SGISILNEIK 

       130        140        150        160        170        180 
ILVKSEDETL QIGFDESYEI YIDDSGDDGG KIIAETVYGA IRGLETLYQM IGFDYQREYY 

       190        200        210        220        230        240 
QIKHCPWIIQ DSPRYPHRGV MLDTSRHFYS VDVLKEFIEA LAYNKFNVFH WHAVDSQSFP 

       250        260        270        280        290        300 
LTSTTFPKIT KGSWSSQEIY STRDIKEIIQ HAKEYGIRVE LEIDMPGHAY SWGIGYPSVL 

       310        320        330        340        350        360 
PANFSHSIQC QQPCPTECNI PLDVSSKESY VIAMGLLEEF NGASMFNESF FHIGGDEVAY 

       370        380        390        400        410        420 
SCWNNSLRIV DWMKRENISS FQDAAIFFEI KAIEQLIQLG KTPVMWEDAY LLFGSSGITE 

       430        440        450        460        470        480 
KLPEEVVVQI YHDPLLALNT TRDGYKTLQS PYWPYYLDNP SVDWEKVYEF EPSNGIHEKR 

       490        500        510        520        530        540 
LRLLLGGETC MWSELVDASN LFAKVFPRAF ATAERLWFSI ENSNSTTFAK PRLERFRCFL 

       550        560 
LERGIGAAPL NSTSPDDPNS CYSS

References

[1]

"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.

expand/collapse author list

Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000103 Genomic DNA. Translation: EAL63638.1.
RefSeq	XP_637108.1. XM_632016.1.
3D structure databases
HSSP	HSSP built from PDB template 1NOW based on UniProtKB P07686.
ProteinModelPortal	Q54K56.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDBDRAFT_0219249.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0304516; DDB0304516; DDB_G0287659.
GeneID	8626203.
KEGG	ddi:DDB_G0287659.
Organism-specific databases
dictyBase	DDB_G0287659. nagD.
Phylogenomic databases
eggNOG	COG3525.
KO	K12373.
OMA	PVNWEET.
ProtClustDB	CLSZ2429971.
Family and domain databases
Gene3D	3.20.20.80. 1 hit.
InterPro	IPR025705. Beta_hexosaminidase_sua/sub. IPR015883. Glyco_hydro_20_cat-core. IPR015882. Glyco_hydro_20b. IPR013781. Glyco_hydro_catalytic_dom. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF00728. Glyco_hydro_20. 1 hit. PF02838. Glyco_hydro_20b. 1 hit. [Graphical view]
PIRSF	PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTS	PR00738. GLHYDRLASE20.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEXB2_DICDI

Accession

Primary (citable) accession number: Q54K56

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents