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Protein

Beta-hexosaminidase subunit B2

Gene

hexb2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei357Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit B2 (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase subunit B2
N-acetyl-beta-glucosaminidase subunit B2
Gene namesi
Name:hexb2
ORF Names:DDB_G0287659
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287659. nagD.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000033123820 – 564Beta-hexosaminidase subunit B2Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi524N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ54K56.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0304516.

Structurei

3D structure databases

ProteinModelPortaliQ54K56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 54Poly-Ser10

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2499. Eukaryota.
COG3525. LUCA.
InParanoidiQ54K56.
KOiK12373.
OMAiKVKVRPD.
PhylomeDBiQ54K56.

Family and domain databases

Gene3Di3.30.379.10. 1 hit.
InterProiView protein in InterPro
IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex-like_dom2.
IPR015883. Glyco_hydro_20_cat.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
PfamiView protein in Pfam
PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54K56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKFIFLIL FFIIGNSIGI KISKEINKIK LNDISIDGEI LLNKSSDSSS
60 70 80 90 100
SQSSKIINIW PMPKKVLNGD ITVYISPHFQ FTTNLTKSTT LKKAMDRYYK
110 120 130 140 150
LIFTEDSKSH SGISILNEIK ILVKSEDETL QIGFDESYEI YIDDSGDDGG
160 170 180 190 200
KIIAETVYGA IRGLETLYQM IGFDYQREYY QIKHCPWIIQ DSPRYPHRGV
210 220 230 240 250
MLDTSRHFYS VDVLKEFIEA LAYNKFNVFH WHAVDSQSFP LTSTTFPKIT
260 270 280 290 300
KGSWSSQEIY STRDIKEIIQ HAKEYGIRVE LEIDMPGHAY SWGIGYPSVL
310 320 330 340 350
PANFSHSIQC QQPCPTECNI PLDVSSKESY VIAMGLLEEF NGASMFNESF
360 370 380 390 400
FHIGGDEVAY SCWNNSLRIV DWMKRENISS FQDAAIFFEI KAIEQLIQLG
410 420 430 440 450
KTPVMWEDAY LLFGSSGITE KLPEEVVVQI YHDPLLALNT TRDGYKTLQS
460 470 480 490 500
PYWPYYLDNP SVDWEKVYEF EPSNGIHEKR LRLLLGGETC MWSELVDASN
510 520 530 540 550
LFAKVFPRAF ATAERLWFSI ENSNSTTFAK PRLERFRCFL LERGIGAAPL
560
NSTSPDDPNS CYSS
Length:564
Mass (Da):64,566
Last modified:May 24, 2005 - v1
Checksum:i0C65D857428ABC9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000103 Genomic DNA. Translation: EAL63638.1.
RefSeqiXP_637108.1. XM_632016.1.

Genome annotation databases

EnsemblProtistsiEAL63638; EAL63638; DDB_G0287659.
GeneIDi8626203.
KEGGiddi:DDB_G0287659.

Entry informationi

Entry nameiHEXB2_DICDI
AccessioniPrimary (citable) accession number: Q54K56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families