Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q54K56 (HEXB2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase subunit B2

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase subunit B2
N-acetyl-beta-glucosaminidase subunit B2
Gene names
Name:hexb2
ORF Names:DDB_G0287659
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 564545Beta-hexosaminidase subunit B2
PRO_0000331238

Regions

Compositional bias45 – 5410Poly-Ser

Sites

Active site3571Proton donor By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential
Glycosylation5511N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q54K56 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 0C65D857428ABC9E

FASTA56464,566
        10         20         30         40         50         60 
MKLKFIFLIL FFIIGNSIGI KISKEINKIK LNDISIDGEI LLNKSSDSSS SQSSKIINIW 

        70         80         90        100        110        120 
PMPKKVLNGD ITVYISPHFQ FTTNLTKSTT LKKAMDRYYK LIFTEDSKSH SGISILNEIK 

       130        140        150        160        170        180 
ILVKSEDETL QIGFDESYEI YIDDSGDDGG KIIAETVYGA IRGLETLYQM IGFDYQREYY 

       190        200        210        220        230        240 
QIKHCPWIIQ DSPRYPHRGV MLDTSRHFYS VDVLKEFIEA LAYNKFNVFH WHAVDSQSFP 

       250        260        270        280        290        300 
LTSTTFPKIT KGSWSSQEIY STRDIKEIIQ HAKEYGIRVE LEIDMPGHAY SWGIGYPSVL 

       310        320        330        340        350        360 
PANFSHSIQC QQPCPTECNI PLDVSSKESY VIAMGLLEEF NGASMFNESF FHIGGDEVAY 

       370        380        390        400        410        420 
SCWNNSLRIV DWMKRENISS FQDAAIFFEI KAIEQLIQLG KTPVMWEDAY LLFGSSGITE 

       430        440        450        460        470        480 
KLPEEVVVQI YHDPLLALNT TRDGYKTLQS PYWPYYLDNP SVDWEKVYEF EPSNGIHEKR 

       490        500        510        520        530        540 
LRLLLGGETC MWSELVDASN LFAKVFPRAF ATAERLWFSI ENSNSTTFAK PRLERFRCFL 

       550        560 
LERGIGAAPL NSTSPDDPNS CYSS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000103 Genomic DNA. Translation: EAL63638.1.

3D structure databases

ProteinModelPortalQ54K56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0219249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0304516; DDB0304516; DDB_G0287659.
KEGGddi:DDB_G0287659.

Organism-specific databases

dictyBaseDDB_G0287659. nagD.

Phylogenomic databases

eggNOGCOG3525.
KOK12373.
OMAHIDAMAY.
PhylomeDBQ54K56.
ProtClustDBCLSZ2429971.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
PIRSFPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSPR00738. GLHYDRLASE20.
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEXB2_DICDI
AccessionPrimary (citable) accession number: Q54K56
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase