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Protein

Beta-hexosaminidase subunit B1

Gene

hexb1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei359Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit B1 (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase subunit B1
N-acetyl-beta-glucosaminidase subunit B1
Gene namesi
Name:hexb1
ORF Names:DDB_G0287597
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287597. nagC.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000033123726 – 560Beta-hexosaminidase subunit B1Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ54K55.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0304520.

Structurei

3D structure databases

SMRiQ54K55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2499. Eukaryota.
COG3525. LUCA.
InParanoidiQ54K55.
OMAiGHDVVMC.
PhylomeDBiQ54K55.

Family and domain databases

Gene3Di3.30.379.10. 1 hit.
InterProiView protein in InterPro
IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex-like_dom2.
IPR015883. Glyco_hydro_20_cat.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
PfamiView protein in Pfam
PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54K55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILKRNIVF LLIIIIVLGI FIATSIEIKN YKLSLNQNKN EISKNPPIWP
60 70 80 90 100
APFYGQFGNN SILISKEFNF TIISDSTLLL NKTLSKYYNL IFTQDNLINS
110 120 130 140 150
SSNTLNKLNI NLKSKNEILK FGFDESYKLI IKNNENSKLE GNTVYGIMRG
160 170 180 190 200
LETFYQLIKY NFSDNSYFIE NCLPLIINDK PRFPHRGVML DTSRHFYSVD
210 220 230 240 250
TILKVIESLS YNKFNTLHWH IIDSQSFPLS SKSYPNLING AWSKSEIYSY
260 270 280 290 300
HDIKRIIKYG KENGIRIQLE IDMPGHAKSW SVGYPDLLPH GWNDSTTTIK
310 320 330 340 350
CPDYDVPLDP SSPLSLPISF GLLSEFSGTD YGYNPNYDDK SNNLFNLTVD
360 370 380 390 400
DLFHVGGDEI EYQCWNNSKR IKDWMNENNL KTFQDVAKQF QLKIIKQLLK
410 420 430 440 450
IGKIPVLWED TFQLFYKDLP KDVIVEIYHD QSTAINATNN GYKIISSIAR
460 470 480 490 500
YWYLEYSYSN WIRAYNFEPT LNISKSNIHL VLGGEGAIWS ESIDSSNLFQ
510 520 530 540 550
KLYPTSSAIA ERLWSPIYYT NLLNAKSRLQ SFRCSLLKRG INSAPLNNSS
560
PLSAFSCYNS
Length:560
Mass (Da):64,555
Last modified:May 24, 2005 - v1
Checksum:iDF3700F79651C682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000103 Genomic DNA. Translation: EAL63607.1.
RefSeqiXP_637109.1. XM_632017.1.

Genome annotation databases

EnsemblProtistsiEAL63607; EAL63607; DDB_G0287597.
GeneIDi8626204.
KEGGiddi:DDB_G0287597.

Entry informationi

Entry nameiHEXB1_DICDI
AccessioniPrimary (citable) accession number: Q54K55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families