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Q54K55 (HEXB1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase subunit B1

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase subunit B1
N-acetyl-beta-glucosaminidase subunit B1
Gene names
Name:hexb1
ORF Names:DDB_G0287597
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 560535Beta-hexosaminidase subunit B1
PRO_0000331237

Sites

Active site3591Proton donor By similarity

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation3461N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation4721N-linked (GlcNAc...) Potential
Glycosylation5471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q54K55 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: DF3700F79651C682

FASTA56064,555
        10         20         30         40         50         60 
MIILKRNIVF LLIIIIVLGI FIATSIEIKN YKLSLNQNKN EISKNPPIWP APFYGQFGNN 

        70         80         90        100        110        120 
SILISKEFNF TIISDSTLLL NKTLSKYYNL IFTQDNLINS SSNTLNKLNI NLKSKNEILK 

       130        140        150        160        170        180 
FGFDESYKLI IKNNENSKLE GNTVYGIMRG LETFYQLIKY NFSDNSYFIE NCLPLIINDK 

       190        200        210        220        230        240 
PRFPHRGVML DTSRHFYSVD TILKVIESLS YNKFNTLHWH IIDSQSFPLS SKSYPNLING 

       250        260        270        280        290        300 
AWSKSEIYSY HDIKRIIKYG KENGIRIQLE IDMPGHAKSW SVGYPDLLPH GWNDSTTTIK 

       310        320        330        340        350        360 
CPDYDVPLDP SSPLSLPISF GLLSEFSGTD YGYNPNYDDK SNNLFNLTVD DLFHVGGDEI 

       370        380        390        400        410        420 
EYQCWNNSKR IKDWMNENNL KTFQDVAKQF QLKIIKQLLK IGKIPVLWED TFQLFYKDLP 

       430        440        450        460        470        480 
KDVIVEIYHD QSTAINATNN GYKIISSIAR YWYLEYSYSN WIRAYNFEPT LNISKSNIHL 

       490        500        510        520        530        540 
VLGGEGAIWS ESIDSSNLFQ KLYPTSSAIA ERLWSPIYYT NLLNAKSRLQ SFRCSLLKRG 

       550        560 
INSAPLNNSS PLSAFSCYNS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000103 Genomic DNA. Translation: EAL63607.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0187537.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0304520; DDB0304520; DDB_G0287597.
KEGGddi:DDB_G0287597.

Organism-specific databases

dictyBaseDDB_G0287597. nagC.

Phylogenomic databases

eggNOGCOG3525.
OMASATCKEP.
PhylomeDBQ54K55.
ProtClustDBCLSZ2429971.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
PIRSFPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSPR00738. GLHYDRLASE20.
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEXB1_DICDI
AccessionPrimary (citable) accession number: Q54K55
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase