Q54K39 (GMPPB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase beta
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta

Gene names

Name:	gmppB
Synonyms:	mpgA
ORF Names:	DDB_G0287619

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	GDP-mannose biosynthetic process Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Mannose-1-phosphate guanyltransferase beta		PRO_0000328173

Sequences

	Sequence		Length	Mass (Da)
	Q54K39 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 9F5028021957969C	FASTA	359	39,354
	10 20 30 40 50 60 MKALILVGGF GTRLRPLTLS KPKPIVEFAN KAMILHQIEA LCKIGVNEVV LAVNYRPQLM 70 80 90 100 110 120 SQYLEPYEKK LGIKISYSHE TVPLGTAGPL ALARDLLNDG EPFFVLNSDI ICDFPFADLL 130 140 150 160 170 180 AFHKSHGGEG TIMVTKVEEP SKYGVVVYKE ENGQILKFVE KPQVYVGNKI NAGVYIFNPT 190 200 210 220 230 240 ILDRIQPKPT SIEKEIFPAM AADSQLYCMQ LEGFWMDVGQ PKDFLSGMGL YLNSLKSKQP 250 260 270 280 290 300 ELLATGNGII GPVLIDPSSV IEPGCLIGPN VTIGPNCVIQ EGTRLVNTTV LEGTTIGKNS 310 320 330 340 350 WIKSTIIGWN SSIGKWVRME NTSVLGEDVH VSDELYINGG KILPHKSITS SIPEPEIIM

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000103 Genomic DNA. Translation: EAL63618.1.
RefSeq	XP_637125.1. XM_632033.1.
3D structure databases
ProteinModelPortal	Q54K39.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54K39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231665; DDB0231665; DDB_G0287619.
GeneID	8626220.
GenomeReviews	Gene locus gmppB in contig CM000154_GR.
KEGG	ddi:DDB_G0287619.
Organism-specific databases
dictyBase	DDB_G0287619. gmppB.
Phylogenomic databases
eggNOG	KOG1322.
GeneTree	EPrGT00050000003299.
HOGENOM	HBG688195.
OMA	DGVCIKR.
PhylomeDB	Q54K39.
ProtClustDB	CLSZ2497141.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPB_DICDI

Accession

Primary (citable) accession number: Q54K39

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)