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Protein

ABC transporter C family member 3

Gene

abcC3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi474 – 481ATPPROSITE-ProRule annotation8
Nucleotide bindingi1096 – 1103ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: dictyBase
  • ATP binding Source: UniProtKB-KW
  • transporter activity Source: dictyBase

GO - Biological processi

  • culmination involved in sorocarp development Source: dictyBase
  • transport Source: dictyBase
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-2142850. Hyaluronan biosynthesis and export.
R-DDI-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter C family member 3
Alternative name(s):
ABC transporter ABCC.3
Gene namesi
Name:abcC3
ORF Names:DDB_G0287691
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287691. abcC3.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei115 – 135HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei161 – 181HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei236 – 256HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei261 – 281HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei346 – 366HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei379 – 399HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei724 – 744HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei787 – 807HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei854 – 874HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei875 – 895HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei967 – 987HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003638491 – 1412ABC transporter C family member 3Add BLAST1412

Proteomic databases

PaxDbiQ54JR2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0216251.

Structurei

3D structure databases

ProteinModelPortaliQ54JR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 405ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST287
Domaini439 – 662ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini735 – 1025ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST291
Domaini1062 – 1296ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1368 – 1406Poly-AsnAdd BLAST39

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ54JR2.
PhylomeDBiQ54JR2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54JR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELEEVGVEA NQPNNDQGSK KQNKNKDKKV KKEKKIGYGG KKSAEENSNF
60 70 80 90 100
ISWLTFSWAD RFVVHCFRHV LQLSHIWDLA SYDKSAYLAE KIAISWDVEI
110 120 130 140 150
KKPKPSYIRA AFRAFGLYFV LSWFFYAIYA ASQFVGPEIL KRMVTFVLKS
160 170 180 190 200
RSGISTEDPN MGYYYALIMF GSAMIGSVCL YQSNMISART GDRLRSVIVL
210 220 230 240 250
DVYRKAIKLS NSARANTSPG EIVNLMSNDA QRMVEVFQLV NNGVFALPQI
260 270 280 290 300
IVCLALLYRA IGWPTFVGLG LMLAAVPFNG IAAKKLTEIR RHLVGFTDKR
310 320 330 340 350
VKTTNEILQA IKIIKLYAWE DSFAKKVIER REAEIKLLFS FSRYRAMLIV
360 370 380 390 400
IVAALPTAVS VLVFSSYYGY YKKLDAGEIF AALSYLNILR LPLGFLPIIV
410 420 430 440 450
ALGIQMKIAA QRVTDFLLLP EMKEISKIED PSIENGIYIR DATLTWNQEK
460 470 480 490 500
KEESFTLKNI NFEAKGKTLT MIVGSVGSGK SSLIQAMLGE MDVLDGSVAM
510 520 530 540 550
KGNVAYVPQQ AWIINATLKD NILFGSPYDE AKYRKVLEVC ALERDIELFP
560 570 580 590 600
QGDLVEIGER GVNLSGGQKQ RVSIARAVYS DSDVYILDDP LSAVDAHVGK
610 620 630 640 650
HLFHRCFKGI LKSKTVILAA NQLNYLPFAH NTVVLKAGEI SERGSYQQLI
660 670 680 690 700
NAQKEFSGLL QAYGVDESAV NEDVEDDKEI EESDNIVVEE KTKPTEKPKL
710 720 730 740 750
QNKDGVLTSQ EEREEGAVAM WVYWKYITVG GGFLFLMAFI FFLMDTGTRT
760 770 780 790 800
FVDWWLSHWQ NESTKNALAV AQGLEPSGLT DTQYLGIYIG VGMTSILISA
810 820 830 840 850
GRNFLFFEYT VRASRALHHQ LFNALLRAPM SFFDTTPLGR IINRFTRDLD
860 870 880 890 900
GVDNLMATSI SQFLVFFTTV VATLIIISII TPFLLVPLAP ICIIFYFLQF
910 920 930 940 950
FYRYTSRELQ RLEAISRSPI FSHFSETLGG VVSIRAYRKK EENILTNQFR
960 970 980 990 1000
LDNNNKCYLT LQAMNQWLGL RLDLLANLVT FFACLFITID RDTISAANVG
1010 1020 1030 1040 1050
LSLSYALSLT GNLNRATLQA ADTETKMNSV ERITHYIKGP VEALQIVEDH
1060 1070 1080 1090 1100
RPAPDWPPHG AITFDNLVMR YREGLDPVLK GISCEIKAKE KIGIVGRTGA
1110 1120 1130 1140 1150
GKSSIVLALF RLIEASEGAI LIDGENIAKF GLKDLRRNLA IIPQDPVLFS
1160 1170 1180 1190 1200
GTLRENIDPF NEKTDDQLWS VLKDIQLHDV AKSLEGGLDS KVTENGDNWS
1210 1220 1230 1240 1250
VGQRQLLCLA RALLRDPKIL VLDEATASVD GHSDSLIQAT IREKFSNCTI
1260 1270 1280 1290 1300
LTIAHRLNTI MDSDRIIVLD AGKISEFDEP WTLLQNPAGL LNWLVEETGP
1310 1320 1330 1340 1350
QNAAYLRRLA QAKKDGVNID QITPPISPTP EQKPFKNADI DNINSPPQQS
1360 1370 1380 1390 1400
LKAEDNPNPK ALDNSGDNNN NNNNNNNNNN NNNNNNNNNN NNNNNNDNDN
1410
DNDNDNSEAG DN
Length:1,412
Mass (Da):158,111
Last modified:May 24, 2005 - v1
Checksum:i7742BD1171062F36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191 – 212Missing in AAL85706 (PubMed:12456012).CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF474335 Genomic DNA. Translation: AAL85706.1.
AAFI02000104 Genomic DNA. Translation: EAL63492.1.
RefSeqiXP_637090.1. XM_631998.1.

Genome annotation databases

EnsemblProtistsiEAL63492; EAL63492; DDB_G0287691.
GeneIDi8626345.
KEGGiddi:DDB_G0287691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF474335 Genomic DNA. Translation: AAL85706.1.
AAFI02000104 Genomic DNA. Translation: EAL63492.1.
RefSeqiXP_637090.1. XM_631998.1.

3D structure databases

ProteinModelPortaliQ54JR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0216251.

Proteomic databases

PaxDbiQ54JR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL63492; EAL63492; DDB_G0287691.
GeneIDi8626345.
KEGGiddi:DDB_G0287691.

Organism-specific databases

dictyBaseiDDB_G0287691. abcC3.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ54JR2.
PhylomeDBiQ54JR2.

Enzyme and pathway databases

ReactomeiR-DDI-2142850. Hyaluronan biosynthesis and export.
R-DDI-382556. ABC-family proteins mediated transport.

Miscellaneous databases

PROiQ54JR2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCC3_DICDI
AccessioniPrimary (citable) accession number: Q54JR2
Secondary accession number(s): Q8T6H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.