Reviewed, UniProtKB/Swiss-Prot Q54JR2 (ABCC3_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter C family member 3
Alternative name(s):
    ABC transporter ABCC.3

Gene names

Name:	abcC3
ORF Names:	DDB_G0287691

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1412	1412	ABC transporter C family member 3		PRO_0000363849
Regions
	Transmembrane	115 – 135	21	Potential
	Transmembrane	161 – 181	21	Potential
	Transmembrane	236 – 256	21	Potential
	Transmembrane	261 – 281	21	Potential
	Transmembrane	346 – 366	21	Potential
	Transmembrane	379 – 399	21	Potential
	Transmembrane	724 – 744	21	Potential
	Transmembrane	787 – 807	21	Potential
	Transmembrane	854 – 874	21	Potential
	Transmembrane	875 – 895	21	Potential
	Transmembrane	967 – 987	21	Potential
	Domain	119 – 405	287	ABC transmembrane type-1 1
	Domain	439 – 662	224	ABC transporter 1
	Domain	735 – 1025	291	ABC transmembrane type-1 2
	Domain	1062 – 1296	235	ABC transporter 2
	Nucleotide binding	474 – 481	8	ATP Potential
	Nucleotide binding	1096 – 1103	8	ATP Potential
	Compositional bias	1368 – 1406	39	Poly-Asn
Experimental info
	Sequence conflict	191 – 212	22	Missing in AAL85706. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q54JR2-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 7742BD1171062F36	FASTA	1,412	158,111
	10 20 30 40 50 60 MELEEVGVEA NQPNNDQGSK KQNKNKDKKV KKEKKIGYGG KKSAEENSNF ISWLTFSWAD 70 80 90 100 110 120 RFVVHCFRHV LQLSHIWDLA SYDKSAYLAE KIAISWDVEI KKPKPSYIRA AFRAFGLYFV 130 140 150 160 170 180 LSWFFYAIYA ASQFVGPEIL KRMVTFVLKS RSGISTEDPN MGYYYALIMF GSAMIGSVCL 190 200 210 220 230 240 YQSNMISART GDRLRSVIVL DVYRKAIKLS NSARANTSPG EIVNLMSNDA QRMVEVFQLV 250 260 270 280 290 300 NNGVFALPQI IVCLALLYRA IGWPTFVGLG LMLAAVPFNG IAAKKLTEIR RHLVGFTDKR 310 320 330 340 350 360 VKTTNEILQA IKIIKLYAWE DSFAKKVIER REAEIKLLFS FSRYRAMLIV IVAALPTAVS 370 380 390 400 410 420 VLVFSSYYGY YKKLDAGEIF AALSYLNILR LPLGFLPIIV ALGIQMKIAA QRVTDFLLLP 430 440 450 460 470 480 EMKEISKIED PSIENGIYIR DATLTWNQEK KEESFTLKNI NFEAKGKTLT MIVGSVGSGK 490 500 510 520 530 540 SSLIQAMLGE MDVLDGSVAM KGNVAYVPQQ AWIINATLKD NILFGSPYDE AKYRKVLEVC 550 560 570 580 590 600 ALERDIELFP QGDLVEIGER GVNLSGGQKQ RVSIARAVYS DSDVYILDDP LSAVDAHVGK 610 620 630 640 650 660 HLFHRCFKGI LKSKTVILAA NQLNYLPFAH NTVVLKAGEI SERGSYQQLI NAQKEFSGLL 670 680 690 700 710 720 QAYGVDESAV NEDVEDDKEI EESDNIVVEE KTKPTEKPKL QNKDGVLTSQ EEREEGAVAM 730 740 750 760 770 780 WVYWKYITVG GGFLFLMAFI FFLMDTGTRT FVDWWLSHWQ NESTKNALAV AQGLEPSGLT 790 800 810 820 830 840 DTQYLGIYIG VGMTSILISA GRNFLFFEYT VRASRALHHQ LFNALLRAPM SFFDTTPLGR 850 860 870 880 890 900 IINRFTRDLD GVDNLMATSI SQFLVFFTTV VATLIIISII TPFLLVPLAP ICIIFYFLQF 910 920 930 940 950 960 FYRYTSRELQ RLEAISRSPI FSHFSETLGG VVSIRAYRKK EENILTNQFR LDNNNKCYLT 970 980 990 1000 1010 1020 LQAMNQWLGL RLDLLANLVT FFACLFITID RDTISAANVG LSLSYALSLT GNLNRATLQA 1030 1040 1050 1060 1070 1080 ADTETKMNSV ERITHYIKGP VEALQIVEDH RPAPDWPPHG AITFDNLVMR YREGLDPVLK 1090 1100 1110 1120 1130 1140 GISCEIKAKE KIGIVGRTGA GKSSIVLALF RLIEASEGAI LIDGENIAKF GLKDLRRNLA 1150 1160 1170 1180 1190 1200 IIPQDPVLFS GTLRENIDPF NEKTDDQLWS VLKDIQLHDV AKSLEGGLDS KVTENGDNWS 1210 1220 1230 1240 1250 1260 VGQRQLLCLA RALLRDPKIL VLDEATASVD GHSDSLIQAT IREKFSNCTI LTIAHRLNTI 1270 1280 1290 1300 1310 1320 MDSDRIIVLD AGKISEFDEP WTLLQNPAGL LNWLVEETGP QNAAYLRRLA QAKKDGVNID 1330 1340 1350 1360 1370 1380 QITPPISPTP EQKPFKNADI DNINSPPQQS LKAEDNPNPK ALDNSGDNNN NNNNNNNNNN 1390 1400 1410 NNNNNNNNNN NNNNNNDNDN DNDNDNSEAG DN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF474335 Genomic DNA. Translation: AAL85706.1. AAFI02000104 Genomic DNA. Translation: EAL63492.1.
RefSeq	XP_637090.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ModBase	Search...
Genome annotation databases
GeneID	3388569.
GenomeReviews	Gene locus abcC3 in contig CM000154_GR.
KEGG	ddi:DDB_0216251.
Organism-specific databases
dictyBase	DDB_G0287691. abcC3.
Phylogenomic databases
OMA	NSARANT
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCC3_DICDI

Accession

Primary (citable) accession number: Q54JR2
Secondary accession number(s): Q8T6H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	November 24, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)