Q54JP5 (OAT_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ornithine aminotransferase
EC=2.6.1.13

Alternative name(s):
Ornithine--oxo-acid aminotransferase

Gene names

Name:	oatA
ORF Names:	DDB_G0287913

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway arginine catabolic process Inferred from sequence or structural similarity. Source: dictyBase ornithine metabolic process Inferred by curator. Source: dictyBase
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ornithine-oxo-acid transaminase activity Inferred from sequence or structural similarity. Source: dictyBase pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Probable ornithine aminotransferase		PRO_0000327775
Amino acid modifications
	Modified residue	267	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54JP5 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 3C7765B82E5073D3	FASTA	416	45,752
	10 20 30 40 50 60 MDPISSQIQE CTSKELIEME SEFAAHTYHP IPVVFKKASG VHVWDVEEKQ YFDFLSAYSA 70 80 90 100 110 120 VNQGHSHPKI VSALITQAQK CALSSRAFYN EVFPQYAKYI TEYFGYEMVL PMNTGAEAVE 130 140 150 160 170 180 TSIKLARRWG YVKKGIAEDQ AIVISCKGCF HGRTIGVISM SDDPSSYNKY GPLMNGIIKI 190 200 210 220 230 240 DYNSTQQLEE VLSQHADRVC GFIVEPIQGE AGVVVPDEGY LKKCYELCKK YNVLLVADEI 250 260 270 280 290 300 QTGLCRTGRM LCSDWDGIKP DLVLLGKAIS GGLLPISAVL GGKDVMLTIK PGEHGSTYGG 310 320 330 340 350 360 SPLASAVAMA ALDVLRDENL AENAQKLGEH FRAQISNINH PAIQLVRGKG LLNAIVIDPN 370 380 390 400 410 FTVSAWDICI KFAENGLLAK PTHDNIIRLA PPLTITLEQI DQCVSIIKKV FDSFKN

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000104 Genomic DNA. Translation: EAL63485.1.
RefSeq	XP_636989.1. XM_631897.1.
3D structure databases
HSSP	HSSP built from PDB template 2OAT based on UniProtKB P04181.
ProteinModelPortal	Q54JP5.
SMR	Q54JP5. Positions 12-414.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0231478.
Proteomic databases
PRIDE	Q54JP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231478; DDB0231478; DDB_G0287913.
GeneID	8626361.
KEGG	ddi:DDB_G0287913.
Organism-specific databases
dictyBase	DDB_G0287913. oatA.
Phylogenomic databases
eggNOG	COG4992.
KO	K00819.
OMA	VIPYNDL.
ProtClustDB	PTZ00125.
Enzyme and pathway databases
UniPathway	UPA00098; UER00358.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR005814. Aminotrans_3. IPR010164. Orn_aminotrans. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF18. PTHR11986:SF18. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01885. Orn_aminotrans. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OAT_DICDI

Accession

Primary (citable) accession number: Q54JP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)