Q54JE4 (ODO1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial
EC=1.2.4.2

Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	ogdh
ORF Names:	DDB_G0288127

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1013 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Enzyme regulation	Catabolite repressed By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial oxoglutarate dehydrogenase complex Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 39	39	Mitochondrion Potential
	Chain	40 – 1013	974	2-oxoglutarate dehydrogenase, mitochondrial		PRO_0000328590

Sequences

	Sequence		Length	Mass (Da)
	Q54JE4 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: CE908E70E8394632	FASTA	1,013	114,068
	10 20 30 40 50 60 MFTLKQVINK SIQTSMKNGV MSSAVKRSFS TVGGINQPKS RKELSESFLD GTSSTYVEDM 70 80 90 100 110 120 FANWVKDPKS VHPSWASFFE SSERGVPAGE AFMSPPTLGS SVATKATPST YTSSGSPKQV 130 140 150 160 170 180 SDSMRLLLLV RAYQVRGHAL ANLDPLGLEV KEEPAEFNPA KYGFTEADMD RPIFVGEGFI 190 200 210 220 230 240 SGFLTNKQPE TTLRQVLKRL KETYCGDIGI EYMHIQDREM CDWIRDKFET SQPVEIPDKE 250 260 270 280 290 300 KIKILERLSW ADQFEGFLGL KYRATRRFGL DGCESLIPGM KAMIDTATED GVESIVLGMP 310 320 330 340 350 360 HRGRLNVLAN VVRKPLPAIF NEFNGGVISI EGEYSATGDV KYHLGTSYDR VTSSGKKVHL 370 380 390 400 410 420 SLVANPSHLE AVNPLVEGKV RAKQHYSKDT EQKKSMAVQL HGDASVAGQG VVYETLHLSN 430 440 450 460 470 480 LDNYSTGGTV HIVVNNQIGF TTNPKYSRSS KYCTDVAKTI DIPVFHVNGD NVEAVVKVCK 490 500 510 520 530 540 IAAEWRQKFK RDVFVDIVCY RKHGHNETDQ PKFTQPIMYD KIGKQQPIIE KYSNKLIAEK 550 560 570 580 590 600 VITQEQYLQM KNIIHESYEK GYQDGMKHVP NAEDWLESRW EGFKSPIELG NPGRTGIDQD 610 620 630 640 650 660 LLQKIGKVLY TEPSGFEVHS TIKRLLKEKK DMFDKGTGFD WATAEALAFG SLLLDGNHVR 670 680 690 700 710 720 LSGQDVERGT FSHRHAVWHD QKTDQTYAPL TKLATALGKK DAAEFVASNS SLSEFAVLGF 730 740 750 760 770 780 ELGYSLENPD ALILWEAQFG DFSNGAQVII DQFISSGEQK WMRQSGLTML LPHGYDGAGP 790 800 810 820 830 840 EHSSCRIERY LQLCDSDPNK IPPKEEAERK QSQHCNMQVL NCSTPVNYFH ALRRQVHRDF 850 860 870 880 890 900 RKPLVIATPK YLLRYEKSFS TAKEFSNDSF TRLYPEAFPD QINKPEKINR IVFCTGQVYY 910 920 930 940 950 960 NLIASRESNN IKDVAIIRVE QLHPFPFDLV AEQLQHYPNA KAIWCQEEPM NMGYWNYIYP 970 980 990 1000 1010 YFISTFKHIN RPADITYTGR PSSASPAVAS HTLHKLQLEN FLSNALTGQV GSK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000109 Genomic DNA. Translation: EAL63408.1.
RefSeq	XP_636906.1. XM_631814.1.
3D structure databases
ProteinModelPortal	Q54JE4.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDBDRAFT_0219311.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0234117; DDB0234117; DDB_G0288127.
GeneID	8626461.
KEGG	ddi:DDB_G0288127.
Organism-specific databases
dictyBase	DDB_G0288127. ogdh.
Phylogenomic databases
eggNOG	COG0567.
KO	K00164.
OMA	RSEAGYP.
ProtClustDB	CLSZ2728844.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_DICDI

Accession

Primary (citable) accession number: Q54JE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)