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Q54JE4

- ODO1_DICDI

UniProt

Q54JE4 - ODO1_DICDI

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Enzyme regulationi

    Catabolite repressed.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1
    Short name:
    OGDC-E1
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:ogdh
    ORF Names:DDB_G0288127
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0288127. ogdh.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial oxoglutarate dehydrogenase complex Source: dictyBase
    2. mitochondrion Source: dictyBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 10139742-oxoglutarate dehydrogenase, mitochondrialPRO_0000328590Add
    BLAST

    Proteomic databases

    PRIDEiQ54JE4.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0219311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54JE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    KOiK00164.
    OMAiDIAFIRI.
    PhylomeDBiQ54JE4.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54JE4-1 [UniParc]FASTAAdd to Basket

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    MFTLKQVINK SIQTSMKNGV MSSAVKRSFS TVGGINQPKS RKELSESFLD     50
    GTSSTYVEDM FANWVKDPKS VHPSWASFFE SSERGVPAGE AFMSPPTLGS 100
    SVATKATPST YTSSGSPKQV SDSMRLLLLV RAYQVRGHAL ANLDPLGLEV 150
    KEEPAEFNPA KYGFTEADMD RPIFVGEGFI SGFLTNKQPE TTLRQVLKRL 200
    KETYCGDIGI EYMHIQDREM CDWIRDKFET SQPVEIPDKE KIKILERLSW 250
    ADQFEGFLGL KYRATRRFGL DGCESLIPGM KAMIDTATED GVESIVLGMP 300
    HRGRLNVLAN VVRKPLPAIF NEFNGGVISI EGEYSATGDV KYHLGTSYDR 350
    VTSSGKKVHL SLVANPSHLE AVNPLVEGKV RAKQHYSKDT EQKKSMAVQL 400
    HGDASVAGQG VVYETLHLSN LDNYSTGGTV HIVVNNQIGF TTNPKYSRSS 450
    KYCTDVAKTI DIPVFHVNGD NVEAVVKVCK IAAEWRQKFK RDVFVDIVCY 500
    RKHGHNETDQ PKFTQPIMYD KIGKQQPIIE KYSNKLIAEK VITQEQYLQM 550
    KNIIHESYEK GYQDGMKHVP NAEDWLESRW EGFKSPIELG NPGRTGIDQD 600
    LLQKIGKVLY TEPSGFEVHS TIKRLLKEKK DMFDKGTGFD WATAEALAFG 650
    SLLLDGNHVR LSGQDVERGT FSHRHAVWHD QKTDQTYAPL TKLATALGKK 700
    DAAEFVASNS SLSEFAVLGF ELGYSLENPD ALILWEAQFG DFSNGAQVII 750
    DQFISSGEQK WMRQSGLTML LPHGYDGAGP EHSSCRIERY LQLCDSDPNK 800
    IPPKEEAERK QSQHCNMQVL NCSTPVNYFH ALRRQVHRDF RKPLVIATPK 850
    YLLRYEKSFS TAKEFSNDSF TRLYPEAFPD QINKPEKINR IVFCTGQVYY 900
    NLIASRESNN IKDVAIIRVE QLHPFPFDLV AEQLQHYPNA KAIWCQEEPM 950
    NMGYWNYIYP YFISTFKHIN RPADITYTGR PSSASPAVAS HTLHKLQLEN 1000
    FLSNALTGQV GSK 1013
    Length:1,013
    Mass (Da):114,068
    Last modified:May 24, 2005 - v1
    Checksum:iCE908E70E8394632
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000109 Genomic DNA. Translation: EAL63408.1.
    RefSeqiXP_636906.1. XM_631814.1.

    Genome annotation databases

    EnsemblProtistsiDDB0234117; DDB0234117; DDB_G0288127.
    GeneIDi8626461.
    KEGGiddi:DDB_G0288127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000109 Genomic DNA. Translation: EAL63408.1 .
    RefSeqi XP_636906.1. XM_631814.1.

    3D structure databases

    ProteinModelPortali Q54JE4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0219311.

    Proteomic databases

    PRIDEi Q54JE4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0234117 ; DDB0234117 ; DDB_G0288127 .
    GeneIDi 8626461.
    KEGGi ddi:DDB_G0288127.

    Organism-specific databases

    dictyBasei DDB_G0288127. ogdh.

    Phylogenomic databases

    eggNOGi COG0567.
    KOi K00164.
    OMAi DIAFIRI.
    PhylomeDBi Q54JE4.

    Miscellaneous databases

    PROi Q54JE4.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiODO1_DICDI
    AccessioniPrimary (citable) accession number: Q54JE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3