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Q54JE4

- ODO1_DICDI

UniProt

Q54JE4 - ODO1_DICDI

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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene
ogdh, DDB_G0288127
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

Enzyme regulationi

Catabolite repressed By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:ogdh
ORF Names:DDB_G0288127
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288127. ogdh.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial oxoglutarate dehydrogenase complex Source: dictyBase
  2. mitochondrion Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion Reviewed predictionAdd
BLAST
Chaini40 – 10139742-oxoglutarate dehydrogenase, mitochondrialPRO_0000328590Add
BLAST

Proteomic databases

PRIDEiQ54JE4.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0219311.

Structurei

3D structure databases

ProteinModelPortaliQ54JE4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiDIAFIRI.
PhylomeDBiQ54JE4.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54JE4-1 [UniParc]FASTAAdd to Basket

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MFTLKQVINK SIQTSMKNGV MSSAVKRSFS TVGGINQPKS RKELSESFLD     50
GTSSTYVEDM FANWVKDPKS VHPSWASFFE SSERGVPAGE AFMSPPTLGS 100
SVATKATPST YTSSGSPKQV SDSMRLLLLV RAYQVRGHAL ANLDPLGLEV 150
KEEPAEFNPA KYGFTEADMD RPIFVGEGFI SGFLTNKQPE TTLRQVLKRL 200
KETYCGDIGI EYMHIQDREM CDWIRDKFET SQPVEIPDKE KIKILERLSW 250
ADQFEGFLGL KYRATRRFGL DGCESLIPGM KAMIDTATED GVESIVLGMP 300
HRGRLNVLAN VVRKPLPAIF NEFNGGVISI EGEYSATGDV KYHLGTSYDR 350
VTSSGKKVHL SLVANPSHLE AVNPLVEGKV RAKQHYSKDT EQKKSMAVQL 400
HGDASVAGQG VVYETLHLSN LDNYSTGGTV HIVVNNQIGF TTNPKYSRSS 450
KYCTDVAKTI DIPVFHVNGD NVEAVVKVCK IAAEWRQKFK RDVFVDIVCY 500
RKHGHNETDQ PKFTQPIMYD KIGKQQPIIE KYSNKLIAEK VITQEQYLQM 550
KNIIHESYEK GYQDGMKHVP NAEDWLESRW EGFKSPIELG NPGRTGIDQD 600
LLQKIGKVLY TEPSGFEVHS TIKRLLKEKK DMFDKGTGFD WATAEALAFG 650
SLLLDGNHVR LSGQDVERGT FSHRHAVWHD QKTDQTYAPL TKLATALGKK 700
DAAEFVASNS SLSEFAVLGF ELGYSLENPD ALILWEAQFG DFSNGAQVII 750
DQFISSGEQK WMRQSGLTML LPHGYDGAGP EHSSCRIERY LQLCDSDPNK 800
IPPKEEAERK QSQHCNMQVL NCSTPVNYFH ALRRQVHRDF RKPLVIATPK 850
YLLRYEKSFS TAKEFSNDSF TRLYPEAFPD QINKPEKINR IVFCTGQVYY 900
NLIASRESNN IKDVAIIRVE QLHPFPFDLV AEQLQHYPNA KAIWCQEEPM 950
NMGYWNYIYP YFISTFKHIN RPADITYTGR PSSASPAVAS HTLHKLQLEN 1000
FLSNALTGQV GSK 1013
Length:1,013
Mass (Da):114,068
Last modified:May 24, 2005 - v1
Checksum:iCE908E70E8394632
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000109 Genomic DNA. Translation: EAL63408.1.
RefSeqiXP_636906.1. XM_631814.1.

Genome annotation databases

EnsemblProtistsiDDB0234117; DDB0234117; DDB_G0288127.
GeneIDi8626461.
KEGGiddi:DDB_G0288127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000109 Genomic DNA. Translation: EAL63408.1 .
RefSeqi XP_636906.1. XM_631814.1.

3D structure databases

ProteinModelPortali Q54JE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0219311.

Proteomic databases

PRIDEi Q54JE4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0234117 ; DDB0234117 ; DDB_G0288127 .
GeneIDi 8626461.
KEGGi ddi:DDB_G0288127.

Organism-specific databases

dictyBasei DDB_G0288127. ogdh.

Phylogenomic databases

eggNOGi COG0567.
KOi K00164.
OMAi DIAFIRI.
PhylomeDBi Q54JE4.

Miscellaneous databases

PROi Q54JE4.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiODO1_DICDI
AccessioniPrimary (citable) accession number: Q54JE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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