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Q54JE4

- ODO1_DICDI

UniProt

Q54JE4 - ODO1_DICDI

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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

Enzyme regulationi

Catabolite repressed.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:ogdh
ORF Names:DDB_G0288127
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288127. ogdh.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial oxoglutarate dehydrogenase complex Source: dictyBase
  2. mitochondrion Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 10139742-oxoglutarate dehydrogenase, mitochondrialPRO_0000328590Add
BLAST

Proteomic databases

PRIDEiQ54JE4.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0219311.

Structurei

3D structure databases

ProteinModelPortaliQ54JE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
InParanoidiQ54JE4.
KOiK00164.
OMAiDIAFIRI.
PhylomeDBiQ54JE4.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54JE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTLKQVINK SIQTSMKNGV MSSAVKRSFS TVGGINQPKS RKELSESFLD
60 70 80 90 100
GTSSTYVEDM FANWVKDPKS VHPSWASFFE SSERGVPAGE AFMSPPTLGS
110 120 130 140 150
SVATKATPST YTSSGSPKQV SDSMRLLLLV RAYQVRGHAL ANLDPLGLEV
160 170 180 190 200
KEEPAEFNPA KYGFTEADMD RPIFVGEGFI SGFLTNKQPE TTLRQVLKRL
210 220 230 240 250
KETYCGDIGI EYMHIQDREM CDWIRDKFET SQPVEIPDKE KIKILERLSW
260 270 280 290 300
ADQFEGFLGL KYRATRRFGL DGCESLIPGM KAMIDTATED GVESIVLGMP
310 320 330 340 350
HRGRLNVLAN VVRKPLPAIF NEFNGGVISI EGEYSATGDV KYHLGTSYDR
360 370 380 390 400
VTSSGKKVHL SLVANPSHLE AVNPLVEGKV RAKQHYSKDT EQKKSMAVQL
410 420 430 440 450
HGDASVAGQG VVYETLHLSN LDNYSTGGTV HIVVNNQIGF TTNPKYSRSS
460 470 480 490 500
KYCTDVAKTI DIPVFHVNGD NVEAVVKVCK IAAEWRQKFK RDVFVDIVCY
510 520 530 540 550
RKHGHNETDQ PKFTQPIMYD KIGKQQPIIE KYSNKLIAEK VITQEQYLQM
560 570 580 590 600
KNIIHESYEK GYQDGMKHVP NAEDWLESRW EGFKSPIELG NPGRTGIDQD
610 620 630 640 650
LLQKIGKVLY TEPSGFEVHS TIKRLLKEKK DMFDKGTGFD WATAEALAFG
660 670 680 690 700
SLLLDGNHVR LSGQDVERGT FSHRHAVWHD QKTDQTYAPL TKLATALGKK
710 720 730 740 750
DAAEFVASNS SLSEFAVLGF ELGYSLENPD ALILWEAQFG DFSNGAQVII
760 770 780 790 800
DQFISSGEQK WMRQSGLTML LPHGYDGAGP EHSSCRIERY LQLCDSDPNK
810 820 830 840 850
IPPKEEAERK QSQHCNMQVL NCSTPVNYFH ALRRQVHRDF RKPLVIATPK
860 870 880 890 900
YLLRYEKSFS TAKEFSNDSF TRLYPEAFPD QINKPEKINR IVFCTGQVYY
910 920 930 940 950
NLIASRESNN IKDVAIIRVE QLHPFPFDLV AEQLQHYPNA KAIWCQEEPM
960 970 980 990 1000
NMGYWNYIYP YFISTFKHIN RPADITYTGR PSSASPAVAS HTLHKLQLEN
1010
FLSNALTGQV GSK
Length:1,013
Mass (Da):114,068
Last modified:May 24, 2005 - v1
Checksum:iCE908E70E8394632
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000109 Genomic DNA. Translation: EAL63408.1.
RefSeqiXP_636906.1. XM_631814.1.

Genome annotation databases

EnsemblProtistsiDDB0234117; DDB0234117; DDB_G0288127.
GeneIDi8626461.
KEGGiddi:DDB_G0288127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000109 Genomic DNA. Translation: EAL63408.1 .
RefSeqi XP_636906.1. XM_631814.1.

3D structure databases

ProteinModelPortali Q54JE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0219311.

Proteomic databases

PRIDEi Q54JE4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0234117 ; DDB0234117 ; DDB_G0288127 .
GeneIDi 8626461.
KEGGi ddi:DDB_G0288127.

Organism-specific databases

dictyBasei DDB_G0288127. ogdh.

Phylogenomic databases

eggNOGi COG0567.
InParanoidi Q54JE4.
KOi K00164.
OMAi DIAFIRI.
PhylomeDBi Q54JE4.

Miscellaneous databases

PROi Q54JE4.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiODO1_DICDI
AccessioniPrimary (citable) accession number: Q54JE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3