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Q54JE4 (ODO1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase, mitochondrial

EC=1.2.4.2
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene names
Name:ogdh
ORF Names:DDB_G0288127
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1013 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Enzyme regulation

Catabolite repressed By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 10139742-oxoglutarate dehydrogenase, mitochondrial
PRO_0000328590

Sequences

Sequence LengthMass (Da)Tools
Q54JE4 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: CE908E70E8394632

FASTA1,013114,068
        10         20         30         40         50         60 
MFTLKQVINK SIQTSMKNGV MSSAVKRSFS TVGGINQPKS RKELSESFLD GTSSTYVEDM 

        70         80         90        100        110        120 
FANWVKDPKS VHPSWASFFE SSERGVPAGE AFMSPPTLGS SVATKATPST YTSSGSPKQV 

       130        140        150        160        170        180 
SDSMRLLLLV RAYQVRGHAL ANLDPLGLEV KEEPAEFNPA KYGFTEADMD RPIFVGEGFI 

       190        200        210        220        230        240 
SGFLTNKQPE TTLRQVLKRL KETYCGDIGI EYMHIQDREM CDWIRDKFET SQPVEIPDKE 

       250        260        270        280        290        300 
KIKILERLSW ADQFEGFLGL KYRATRRFGL DGCESLIPGM KAMIDTATED GVESIVLGMP 

       310        320        330        340        350        360 
HRGRLNVLAN VVRKPLPAIF NEFNGGVISI EGEYSATGDV KYHLGTSYDR VTSSGKKVHL 

       370        380        390        400        410        420 
SLVANPSHLE AVNPLVEGKV RAKQHYSKDT EQKKSMAVQL HGDASVAGQG VVYETLHLSN 

       430        440        450        460        470        480 
LDNYSTGGTV HIVVNNQIGF TTNPKYSRSS KYCTDVAKTI DIPVFHVNGD NVEAVVKVCK 

       490        500        510        520        530        540 
IAAEWRQKFK RDVFVDIVCY RKHGHNETDQ PKFTQPIMYD KIGKQQPIIE KYSNKLIAEK 

       550        560        570        580        590        600 
VITQEQYLQM KNIIHESYEK GYQDGMKHVP NAEDWLESRW EGFKSPIELG NPGRTGIDQD 

       610        620        630        640        650        660 
LLQKIGKVLY TEPSGFEVHS TIKRLLKEKK DMFDKGTGFD WATAEALAFG SLLLDGNHVR 

       670        680        690        700        710        720 
LSGQDVERGT FSHRHAVWHD QKTDQTYAPL TKLATALGKK DAAEFVASNS SLSEFAVLGF 

       730        740        750        760        770        780 
ELGYSLENPD ALILWEAQFG DFSNGAQVII DQFISSGEQK WMRQSGLTML LPHGYDGAGP 

       790        800        810        820        830        840 
EHSSCRIERY LQLCDSDPNK IPPKEEAERK QSQHCNMQVL NCSTPVNYFH ALRRQVHRDF 

       850        860        870        880        890        900 
RKPLVIATPK YLLRYEKSFS TAKEFSNDSF TRLYPEAFPD QINKPEKINR IVFCTGQVYY 

       910        920        930        940        950        960 
NLIASRESNN IKDVAIIRVE QLHPFPFDLV AEQLQHYPNA KAIWCQEEPM NMGYWNYIYP 

       970        980        990       1000       1010 
YFISTFKHIN RPADITYTGR PSSASPAVAS HTLHKLQLEN FLSNALTGQV GSK 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000109 Genomic DNA. Translation: EAL63408.1.

3D structure databases

ProteinModelPortalQ54JE4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0219311.

Proteomic databases

PRIDEQ54JE4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0234117; DDB0234117; DDB_G0288127.
KEGGddi:DDB_G0288127.

Organism-specific databases

dictyBaseDDB_G0288127. ogdh.

Phylogenomic databases

eggNOGCOG0567.
KOK00164.
OMARSEAGYP.
PhylomeDBQ54JE4.
ProtClustDBCLSZ2728844.

Family and domain databases

InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Other

PROQ54JE4.

Entry information

Entry nameODO1_DICDI
AccessionPrimary (citable) accession number: Q54JE4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase