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Protein

60 kDa heat shock protein, mitochondrial

Gene

hspA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • asexual reproduction Source: dictyBase
  • positive phototaxis Source: dictyBase
  • protein refolding Source: InterPro
  • sorocarp morphogenesis Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa heat shock protein, mitochondrial
Alternative name(s):
60 kDa chaperonin
Chaperonin 60
Short name:
CPN60
Heat shock protein 60
Short name:
HSP-60
Short name:
Hsp60
Gene namesi
Name:hspA
ORF Names:DDB_G0288181
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288181. hspA.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000316526? – 55660 kDa heat shock protein, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ54J97.
PRIDEiQ54J97.

Expressioni

Inductioni

By heat shock.By similarity

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0219929.

Structurei

3D structure databases

ProteinModelPortaliQ54J97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
InParanoidiQ54J97.
KOiK04077.
OMAiFMNIGAK.
PhylomeDBiQ54J97.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54J97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRQIANKST KFGLRNYSTG KDIKFGAECR ALMLRGVEQL AAAVEVTLGP
60 70 80 90 100
KGRNVILDQP FGQPKITKDG VTVAKHIEFA DRHINLGAQL VKGVASSQND
110 120 130 140 150
QSGDGTTTAT ILTRAIFAEG CKAVAAGMNP MDLWRGINFA VEKVVGELKT
160 170 180 190 200
ISRPISSTEE ISQVATISAN GDKVIGNLIA NAMEKIGKEG VITVQDGKTL
210 220 230 240 250
KDELEIIEGM KFDQGFISRY FINDAKEQKC EFDDPVILVV DGKISNVQQL
260 270 280 290 300
VPILELVHSK HKKLVIIADN IEGDALSALI FNKMRGLQVC AVKAPGFGDL
310 320 330 340 350
KRVNLQDIAV ISGAQVISEE LGVRLEDVDI TMLGSAKKIT IDSDSTIILD
360 370 380 390 400
GAGDKAAIQE RVELIRESLT RTTSDYDKTQ LETRLAKIGG GVAVIRVGGA
410 420 430 440 450
SEVEVGEKKD RITDALNATK AAVEEGIVPG GGTALLYSTL ALKKIKMDNF
460 470 480 490 500
DQTIGVKIVR DALLIPCKTI ANNAGVEGSV VIGRLLSKRD FEYGYNAQKG
510 520 530 540 550
VYENMIQAGI IDPTKVVRTA LIDAASVASL MTTTEAMVVE IKKDTPMPQM

PPQMDY
Length:556
Mass (Da):59,846
Last modified:May 24, 2005 - v1
Checksum:iD4B0DD4D0EC89845
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139F → S in AAB17277 (Ref. 1) Curated1
Sequence conflicti139F → S in AAK49534 (PubMed:12952082).Curated1
Sequence conflicti309A → G in AAB17277 (Ref. 1) Curated1
Sequence conflicti309A → G in AAK49534 (PubMed:12952082).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72247 mRNA. Translation: AAB17277.1.
AF359268 Genomic DNA. Translation: AAK49534.1.
AAFI02000109 Genomic DNA. Translation: EAL63321.1.
RefSeqiXP_636839.1. XM_631747.1.

Genome annotation databases

EnsemblProtistsiEAL63321; EAL63321; DDB_G0288181.
GeneIDi8626508.
KEGGiddi:DDB_G0288181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72247 mRNA. Translation: AAB17277.1.
AF359268 Genomic DNA. Translation: AAK49534.1.
AAFI02000109 Genomic DNA. Translation: EAL63321.1.
RefSeqiXP_636839.1. XM_631747.1.

3D structure databases

ProteinModelPortaliQ54J97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0219929.

Proteomic databases

PaxDbiQ54J97.
PRIDEiQ54J97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL63321; EAL63321; DDB_G0288181.
GeneIDi8626508.
KEGGiddi:DDB_G0288181.

Organism-specific databases

dictyBaseiDDB_G0288181. hspA.

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
InParanoidiQ54J97.
KOiK04077.
OMAiFMNIGAK.
PhylomeDBiQ54J97.

Miscellaneous databases

PROiQ54J97.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_DICDI
AccessioniPrimary (citable) accession number: Q54J97
Secondary accession number(s): Q95025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.