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Protein

Frizzled and smoothened-like protein F

Gene

fslF

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled and smoothened-like protein F
Gene namesi
Name:fslF
ORF Names:DDB_0231315
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288253. fslF.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 244ExtracellularSequence analysisAdd BLAST227
Transmembranei245 – 265Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini266 – 275CytoplasmicSequence analysis10
Transmembranei276 – 296Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini297 – 321ExtracellularSequence analysisAdd BLAST25
Transmembranei322 – 342Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini343 – 353CytoplasmicSequence analysisAdd BLAST11
Transmembranei354 – 374Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini375 – 397ExtracellularSequence analysisAdd BLAST23
Transmembranei398 – 418Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini419 – 442CytoplasmicSequence analysisAdd BLAST24
Transmembranei443 – 463Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini464 – 495ExtracellularSequence analysisAdd BLAST32
Transmembranei496 – 516Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini517 – 591CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000037136818 – 591Frizzled and smoothened-like protein FAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 105By similarity
Disulfide bondi48 ↔ 98By similarity
Disulfide bondi123 ↔ 174By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ54J77.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 177FZAdd BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi563 – 566Poly-Asn4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000112660.
InParanoidiQ54J77.
PhylomeDBiQ54J77.

Family and domain databases

InterProiView protein in InterPro
IPR000832. GPCR_2_secretin-like.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54J77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILIIFIIF IISYISGFEI PKGFGIGLVI PDAECLNYIG DPIDQQLCNS
60 70 80 90 100
KLQNNGDRIY TTTNSQIDSQ TNIKKSFEAI TFLQDQCKDL LFAQFGICDI
110 120 130 140 150
YLAPCIEVTL TPLKSISLPQ RFCKSVCDRM VSNCPRLEEQ MDCSNSFLFP
160 170 180 190 200
EIGTFYDLSP YGYTIDNGTF AVPCSDPTIF FNQVSSNSSF IEICPSPLLL
210 220 230 240 250
KNSSDPEYAA NKGYSYLSPS NCVLPCPVPN YSNQKWDQLL TMSKILSTIS
260 270 280 290 300
FILSLYNVLT FGIINKKVSD PHKCTCFFSG SIALVNLCDI ITYGIGYEEL
310 320 330 340 350
LCPEPGRSAK QQLDPVCGLT GAFFHLGITY CVLWSMTMGL VLYCSVKRQK
360 370 380 390 400
WFKFNYFLIG NTTFTITTVV IAAATSKFEA GLGSIECWIR DRWYAISLFW
410 420 430 440 450
IPCGIALLIG SFCIIAVIHE VYKTSKKSIS NRNDLLQREL KPLLIVIFIS
460 470 480 490 500
GSFLYLFIFF FDIERKFGGY RSAVEDYVLC LLNGSQEECF TTGPSYVPYF
510 520 530 540 550
LFYLVIRWFG IIFFLFYGTS NIARKIWVQN KIWKSISSSI SPKSTPKSSP
560 570 580 590
KNSDSKINSN STNNNNMILN DNNDKNLNEK KAVELESIKI N
Length:591
Mass (Da):66,711
Last modified:May 24, 2005 - v1
Checksum:iDA4ABBAA2B2CD988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000109 Genomic DNA. Translation: EAL63308.1.
RefSeqiXP_636810.1. XM_631718.1.

Genome annotation databases

EnsemblProtistsiEAL63308; EAL63308; DDB_G0288253.
GeneIDi8626527.
KEGGiddi:DDB_G0288253.

Similar proteinsi

Entry informationi

Entry nameiFSLF_DICDI
AccessioniPrimary (citable) accession number: Q54J77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: May 10, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families