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Q54J66 (SYTC1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable threonine--tRNA ligase 1, cytoplasmic
EC=6.1.1.3
Alternative name(s):
Threonyl-tRNA synthetase
Short name=ThrRS
Gene names
Name:thrS1
ORF Names:DDB_G0288267
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length710 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processthreonyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentphagocytic vesicle

Inferred from direct assay. Source: dictyBase

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

threonine-tRNA ligase activity

Inferred from sequence or structural similarity. Source: dictyBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 710710Probable threonine--tRNA ligase 1, cytoplasmic
PRO_0000333831

Sequences

Sequence LengthMass (Da)Tools
Q54J66 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 1D6E143FE62908A2

FASTA71081,187
        10         20         30         40         50         60 
MSDSQENKPV ETPTEVKPVA EKKPAAEKKE KKPAVKKVGV METLQTPDYV KERIEIWESL 

        70         80         90        100        110        120 
KAKHLESLKD MKEEPINVTL PDGKVVAGIK NKTTPYDIAK GISRGLADSI VSSKVNGEQI 

       130        140        150        160        170        180 
WDISRPLEAD CNLQLCKFDS EEGKKTFWHS SAHILGQAME RIYGGQLCIG PATSEGFYYD 

       190        200        210        220        230        240 
MAMGDKIVSA EDYKLINEVA QKIVQEKQPF ERLAVPRDIA LTMFKFNKYK TEIISKIPQE 

       250        260        270        280        290        300 
DTVSLYRCGT LVDLCRGPHV PNTSYIKSFA VTKNSSAYWL GKAENDDLQR VYGISFPDKK 

       310        320        330        340        350        360 
QMEEYENFMR EAALRDHRNV GKAQELFFFH PYSPGSAFFL PHGTRIYNKL VEFIREEYHR 

       370        380        390        400        410        420 
RGFTEVISPS IFSQKLWEQS GHWQKYSENM FVLPVDKDNF SLKPMNCPGH CLMFGSRQRS 

       430        440        450        460        470        480 
YRELPLRFAD FGVLHRNELA GALTGLTRVR KFQQDDAHIF CTTEMIEDEI NSCLGFMQYV 

       490        500        510        520        530        540 
YGIFGFEFGL ELSTRPDNFL GEIAQWDIAE ASLEKALNKF GKPWKLNPKD GAFYGPKIDI 

       550        560        570        580        590        600 
HITDCLKRSH QCATIQLDFQ LPIRFDLEYQ SDDAAELKKR PVIIHRAILG SVERMMAILI 

       610        620        630        640        650        660 
EHTGGKWPLW VSPRQAIVVT VNKTHNEYGQ KVCKEISDAG FYCDIDDSDK TISKKVREAQ 

       670        680        690        700        710 
LAQYNYILVV GQEEINGNTV NVRTRDNVVR GSLTVNDLIS EFKQLVKEFK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFI02000109 Genomic DNA. Translation: EAL63315.1.
RefSeqXP_636821.1. XM_631729.1.

3D structure databases

HSSPHSSP built from PDB template 1WWT based on UniProtKB P26639.
ProteinModelPortalQ54J66.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ54J66.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231248; DDB0231248; DDB_G0288267.
GeneID8626539.
GenomeReviewsGene locus thrS1 in contig CM000154_GR.
KEGGddi:DDB_G0288267.

Organism-specific databases

dictyBaseDDB_G0288267. thrS1.

Phylogenomic databases

eggNOGKOG1637.
GeneTreeEPrGT00050000002539.
HOGENOMHBG352811.
OMAHYAENMF.
PhylomeDBQ54J66.
ProtClustDBCLSZ2728842.

Family and domain databases

InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_ferredoxin-type.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-synth_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
KOK01868.
PfamPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSPR01047. TRNASYNTHTHR.
SMARTSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMSSF52954. Anticodon_bd. 1 hit.
SSF81271. TGS-like. 1 hit.
SSF55186. Thr/Ala-tRNA-synth_IIc_edit. 1 hit.
TIGRFAMsTIGR00418. ThrS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYTC1_DICDI
AccessionPrimary (citable) accession number: Q54J66
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 24, 2005
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

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