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Q54J08

- ACAC_DICDI

UniProt

Q54J08 - ACAC_DICDI

Protein

Acetyl-CoA carboxylase

Gene

accA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase By similarity.By similarity

    Catalytic activityi

    ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
    ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

    Cofactori

    Biotin.By similarity
    Binds 2 manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi319 – 3191Manganese 1By similarity
    Metal bindingi331 – 3311Manganese 1By similarity
    Metal bindingi331 – 3311Manganese 2By similarity
    Metal bindingi333 – 3331Manganese 2By similarity
    Active sitei335 – 3351By similarity
    Binding sitei1761 – 17611Coenzyme ABy similarity
    Binding sitei2068 – 20681Coenzyme ABy similarity
    Binding sitei2070 – 20701Coenzyme ABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi196 – 25358ATPPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. acetyl-CoA carboxylase activity Source: dictyBase
    2. ATP binding Source: UniProtKB-KW
    3. biotin carboxylase activity Source: dictyBase
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fatty acid biosynthetic process Source: dictyBase
    2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    3. nuclear envelope organization Source: dictyBase
    4. protein import into nucleus Source: dictyBase

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Biotin, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00655; UER00711.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA carboxylase (EC:6.4.1.2)
    Alternative name(s):
    ACC-alpha
    Including the following 1 domains:
    Biotin carboxylase (EC:6.3.4.14)
    Gene namesi
    Name:accA
    ORF Names:DDB_G0288387
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0288387. accA.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: dictyBase
    2. endoplasmic reticulum membrane Source: dictyBase
    3. mitochondrion Source: dictyBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22822282Acetyl-CoA carboxylasePRO_0000328220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei687 – 6871N6-biotinyllysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0230067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54J08.
    SMRiQ54J08. Positions 4-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 515500Biotin carboxylationAdd
    BLAST
    Domaini170 – 360191ATP-graspPROSITE-ProRule annotationAdd
    BLAST
    Domaini647 – 71973Biotinyl-bindingAdd
    BLAST
    Domaini1639 – 2138500CarboxyltransferaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi82 – 854Poly-Asn
    Compositional biasi210 – 2156Poly-Gly
    Compositional biasi825 – 8317Poly-Asp
    Compositional biasi943 – 9464Poly-Leu
    Compositional biasi1012 – 10154Poly-Gln

    Sequence similaritiesi

    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
    Contains 1 biotin carboxylation domain.Curated
    Contains 1 biotinyl-binding domain.Curated
    Contains 1 carboxyltransferase domain.Curated

    Phylogenomic databases

    eggNOGiCOG0511.
    KOiK11262.
    OMAiCERIEEN.
    PhylomeDBiQ54J08.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProiIPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR001882. Biotin_BS.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view]
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00188. BIOTIN. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54J08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEINEYIKK LGGDKNIEKI LIANNGIAAV KAIRSVRKWA YTNFGNERAI     50
    KFVVMATPED MKANAEYIRM ADQILQVPGG SNNNNYANVD IIVDFAERAG 100
    VQAVWAGWGH ASENPRLPDL LSKTETGIVF IGPPAKAMAD LGDKIASTIV 150
    AQSARVACVP WSGSGLKVDY SECNGVPSEI YGRACINSVE EARECAQRVG 200
    FPAMIKASEG GGGKGIRKVT SMEDLESSFR QVQNEVPGSP IFFMKLVSNA 250
    RHLEVQIVAD RHGEAISLNG RDCSVQRRHQ KIIEEGPAIA PTPQVWEEME 300
    RAAVRLVKEV GYVGAGTVEY LFAEGEYYFL ELNPRLQVEH PVTEQITGVN 350
    LPATQLQIAM GIPLHRIPDI RKLYGRTGDD LYGDSMIDLH DFTKRNPPAG 400
    HCIAVRITGE NPDEGFKPTS GQIHELTFRS TPNIWGYFSV GAKGGLHEYA 450
    DSQFGHIFAN GATREEARKT IILGLKEISI RGDIRTPVEY IIHLLESKDF 500
    KENHIHTGWL DQLISEKIQT KKPETMIVVL CGAIYKASTI FSTKIQEFSN 550
    QLSNGQLPSL ELLNNSLPIE LIYNNVKYQF EVSRTGINNY SVCLKNDKSA 600
    VSIDSSVIML SDSGLLILLN GSTHVCYGRE DVIGLSLMID SKTCVFSQEY 650
    DPSILRTSSP GKLVRYLVDD GSLVVKGTPF AEIEVMKMYM PLLVPEKGII 700
    KFVLTEGSVM APGAIIANLE LSDQSSIQKS TVFTGSLTKM SPPTLIGNKP 750
    HQLLNYTLGK ISNVLCGYES NDLNQLLNDT IKQLSNQKLP LFEFKEQLSI 800
    VQSRIPQSLF KLINDELNKF EFNNDDDDED DSELFNSKNL QLSISLYLNK 850
    LLLENEQLSI AIQLLIKPII LLAEKYNDGV SFAAINIFKN YLEEFIQIET 900
    NLQNKNIQTV LKSIRPTYKD NISKVVDIAQ SLHPQSKKYK FILLLLNKIQ 950
    EQGLVCDFVE QFKKLSSLGG NCMEISLKAK HIMVHSQLPS NKQRSNDLIN 1000
    SLKSILNVNN EQQQQVDEKV QDNKDEKISK LSKQTNEISD ILIPMFFNES 1050
    NNDDDIRKLA MEVYVRHSYR SYYVEDTKVT LSNDEGSSGF SFIEWHFYIN 1100
    LPQQSNLGGS NSGSPTYGSP LIRSISSSGG SSGGSGFQIS PRPSMSIFNG 1150
    LSMLRTDSTD SLTAMEDQTK LRYGMMVFFE NEKKFEEKLP LILTRYNEEN 1200
    NKKSQLSLSP NESTDILSVI ISIYPESISQ ENQAISSFQS ILKGYIKELS 1250
    IARIRRITFI CCGGDEGKPL KYFTFRERHM YMEDPIFRHI EPAMAYHLEV 1300
    RKLSNFDITH VPTTSQRIHL YYAQEKGKKE TDPDADRSFF VRSVIRYSDL 1350
    YGHSNEIKVD ILLSQIETLL SESIESLEIA MSNKKYEKAQ NHSIFLNVMP 1400
    EVMFDEKMIG YVVQEIGDRL GKRLWKLRVG RVEVRGRIRK GDGLIPVRFF 1450
    VQNPTGYAFQ VQCYYEQQNS IGQMVFAVVP GSSKGSWEGL PVDTPYPIMD 1500
    AVQRNRFKAQ RLDTTYCYDY PDLFREAMQN IWMEFMESNK TNPVKVYPSS 1550
    RGVLESVELI LPSTINTDFP PSIPLDQLPE ESKPKLEETY RPIGYNDIGM 1600
    VAWRMTFYTP EYPLGRQAIV IANDITHQIG SFGPQEDMLF KLASELARKE 1650
    KIPRIYLSSN SGARIGLADE IKSKFKVTWN VPSDPTKGIK NLYLTNNDYQ 1700
    ALKDSVIAYQ DTTDKDKWII HDIIGQKNGI GVENLSWSGL IAGETSQAYN 1750
    EIFTITLVSG RSVGIGAYLV RLGQRTIQND APIILTGASA LNKVLGKEVY 1800
    ESNQQLGGSQ IMYPNGVSHI IVNDELRGIT NVLQWLSFVP KSGGEMVPII 1850
    SPIDSPHRDI EFDPSNSING KCDTRHLIAG LQSELDPNYW ISGMFDKDSF 1900
    METLAGWANT VITGRARLGG IPVGIIAVET KSVEKIIPAD PANPLSYEQV 1950
    NTQAGQVWYP DSSFKTAQAI ADFNNGEELP LMILANWRGF SGGMRDMFDE 2000
    ILKFGSMIVD NLRNYKQPVM VYIPPFAELR GGAWVVLDST INLDMMEMYC 2050
    SEEGRGGVLE PNGIAEIKYR DPELIKTMHR LDPKLIEWDK SIPIGVSVNG 2100
    LDQSQKTIKS QIQQREKELL GIYQQIAIKF ADLHDTPGRM KAKGVIKQMV 2150
    PWKSARSFFY DRIKRRLFEE DKLKLIDKSH PGLNRQSKLN LLETWIKQIL 2200
    GNNQSVDYHQ NDKLISSTIE SNSHIINDKI IDLSKQYAIN QILNFVQSDS 2250
    ESIVDGFQNL LPFISTQQKE FLFESLKKDL NK 2282
    Length:2,282
    Mass (Da):256,735
    Last modified:May 24, 2005 - v1
    Checksum:iBDBEA99629EE1B2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000111 Genomic DNA. Translation: EAL63219.1.
    RefSeqiXP_636722.1. XM_631630.1.

    Genome annotation databases

    EnsemblProtistsiDDB0230067; DDB0230067; DDB_G0288387.
    GeneIDi8626599.
    KEGGiddi:DDB_G0288387.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000111 Genomic DNA. Translation: EAL63219.1 .
    RefSeqi XP_636722.1. XM_631630.1.

    3D structure databases

    ProteinModelPortali Q54J08.
    SMRi Q54J08. Positions 4-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0230067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0230067 ; DDB0230067 ; DDB_G0288387 .
    GeneIDi 8626599.
    KEGGi ddi:DDB_G0288387.

    Organism-specific databases

    dictyBasei DDB_G0288387. accA.

    Phylogenomic databases

    eggNOGi COG0511.
    KOi K11262.
    OMAi CERIEEN.
    PhylomeDBi Q54J08.

    Enzyme and pathway databases

    UniPathwayi UPA00655 ; UER00711 .

    Miscellaneous databases

    PROi Q54J08.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProi IPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR001882. Biotin_BS.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view ]
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00188. BIOTIN. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiACAC_DICDI
    AccessioniPrimary (citable) accession number: Q54J08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3