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Q54J08

- ACAC_DICDI

UniProt

Q54J08 - ACAC_DICDI

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Protein
Acetyl-CoA carboxylase
Gene
accA, DDB_G0288387
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase By similarity.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactori

Biotin By similarity.
Binds 2 manganese ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi319 – 3191Manganese 1 By similarity
Metal bindingi331 – 3311Manganese 1 By similarity
Metal bindingi331 – 3311Manganese 2 By similarity
Metal bindingi333 – 3331Manganese 2 By similarity
Active sitei335 – 3351 By similarity
Binding sitei1761 – 17611Coenzyme A By similarity
Binding sitei2068 – 20681Coenzyme A By similarity
Binding sitei2070 – 20701Coenzyme A By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 25358ATP By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acetyl-CoA carboxylase activity Source: dictyBase
  3. biotin carboxylase activity Source: dictyBase
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: dictyBase
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  3. nuclear envelope organization Source: dictyBase
  4. protein import into nucleus Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA carboxylase (EC:6.4.1.2)
Alternative name(s):
ACC-alpha
Including the following 1 domains:
Biotin carboxylase (EC:6.3.4.14)
Gene namesi
Name:accA
ORF Names:DDB_G0288387
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288387. accA.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: dictyBase
  2. endoplasmic reticulum membrane Source: dictyBase
  3. mitochondrion Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22822282Acetyl-CoA carboxylase
PRO_0000328220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei687 – 6871N6-biotinyllysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0230067.

Structurei

3D structure databases

ProteinModelPortaliQ54J08.
SMRiQ54J08. Positions 4-497.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 515500Biotin carboxylation
Add
BLAST
Domaini170 – 360191ATP-grasp
Add
BLAST
Domaini647 – 71973Biotinyl-binding
Add
BLAST
Domaini1639 – 2138500Carboxyltransferase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi82 – 854Poly-Asn
Compositional biasi210 – 2156Poly-Gly
Compositional biasi825 – 8317Poly-Asp
Compositional biasi943 – 9464Poly-Leu
Compositional biasi1012 – 10154Poly-Gln

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0511.
KOiK11262.
OMAiCERIEEN.
PhylomeDBiQ54J08.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProiIPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54J08-1 [UniParc]FASTAAdd to Basket

« Hide

MIEINEYIKK LGGDKNIEKI LIANNGIAAV KAIRSVRKWA YTNFGNERAI     50
KFVVMATPED MKANAEYIRM ADQILQVPGG SNNNNYANVD IIVDFAERAG 100
VQAVWAGWGH ASENPRLPDL LSKTETGIVF IGPPAKAMAD LGDKIASTIV 150
AQSARVACVP WSGSGLKVDY SECNGVPSEI YGRACINSVE EARECAQRVG 200
FPAMIKASEG GGGKGIRKVT SMEDLESSFR QVQNEVPGSP IFFMKLVSNA 250
RHLEVQIVAD RHGEAISLNG RDCSVQRRHQ KIIEEGPAIA PTPQVWEEME 300
RAAVRLVKEV GYVGAGTVEY LFAEGEYYFL ELNPRLQVEH PVTEQITGVN 350
LPATQLQIAM GIPLHRIPDI RKLYGRTGDD LYGDSMIDLH DFTKRNPPAG 400
HCIAVRITGE NPDEGFKPTS GQIHELTFRS TPNIWGYFSV GAKGGLHEYA 450
DSQFGHIFAN GATREEARKT IILGLKEISI RGDIRTPVEY IIHLLESKDF 500
KENHIHTGWL DQLISEKIQT KKPETMIVVL CGAIYKASTI FSTKIQEFSN 550
QLSNGQLPSL ELLNNSLPIE LIYNNVKYQF EVSRTGINNY SVCLKNDKSA 600
VSIDSSVIML SDSGLLILLN GSTHVCYGRE DVIGLSLMID SKTCVFSQEY 650
DPSILRTSSP GKLVRYLVDD GSLVVKGTPF AEIEVMKMYM PLLVPEKGII 700
KFVLTEGSVM APGAIIANLE LSDQSSIQKS TVFTGSLTKM SPPTLIGNKP 750
HQLLNYTLGK ISNVLCGYES NDLNQLLNDT IKQLSNQKLP LFEFKEQLSI 800
VQSRIPQSLF KLINDELNKF EFNNDDDDED DSELFNSKNL QLSISLYLNK 850
LLLENEQLSI AIQLLIKPII LLAEKYNDGV SFAAINIFKN YLEEFIQIET 900
NLQNKNIQTV LKSIRPTYKD NISKVVDIAQ SLHPQSKKYK FILLLLNKIQ 950
EQGLVCDFVE QFKKLSSLGG NCMEISLKAK HIMVHSQLPS NKQRSNDLIN 1000
SLKSILNVNN EQQQQVDEKV QDNKDEKISK LSKQTNEISD ILIPMFFNES 1050
NNDDDIRKLA MEVYVRHSYR SYYVEDTKVT LSNDEGSSGF SFIEWHFYIN 1100
LPQQSNLGGS NSGSPTYGSP LIRSISSSGG SSGGSGFQIS PRPSMSIFNG 1150
LSMLRTDSTD SLTAMEDQTK LRYGMMVFFE NEKKFEEKLP LILTRYNEEN 1200
NKKSQLSLSP NESTDILSVI ISIYPESISQ ENQAISSFQS ILKGYIKELS 1250
IARIRRITFI CCGGDEGKPL KYFTFRERHM YMEDPIFRHI EPAMAYHLEV 1300
RKLSNFDITH VPTTSQRIHL YYAQEKGKKE TDPDADRSFF VRSVIRYSDL 1350
YGHSNEIKVD ILLSQIETLL SESIESLEIA MSNKKYEKAQ NHSIFLNVMP 1400
EVMFDEKMIG YVVQEIGDRL GKRLWKLRVG RVEVRGRIRK GDGLIPVRFF 1450
VQNPTGYAFQ VQCYYEQQNS IGQMVFAVVP GSSKGSWEGL PVDTPYPIMD 1500
AVQRNRFKAQ RLDTTYCYDY PDLFREAMQN IWMEFMESNK TNPVKVYPSS 1550
RGVLESVELI LPSTINTDFP PSIPLDQLPE ESKPKLEETY RPIGYNDIGM 1600
VAWRMTFYTP EYPLGRQAIV IANDITHQIG SFGPQEDMLF KLASELARKE 1650
KIPRIYLSSN SGARIGLADE IKSKFKVTWN VPSDPTKGIK NLYLTNNDYQ 1700
ALKDSVIAYQ DTTDKDKWII HDIIGQKNGI GVENLSWSGL IAGETSQAYN 1750
EIFTITLVSG RSVGIGAYLV RLGQRTIQND APIILTGASA LNKVLGKEVY 1800
ESNQQLGGSQ IMYPNGVSHI IVNDELRGIT NVLQWLSFVP KSGGEMVPII 1850
SPIDSPHRDI EFDPSNSING KCDTRHLIAG LQSELDPNYW ISGMFDKDSF 1900
METLAGWANT VITGRARLGG IPVGIIAVET KSVEKIIPAD PANPLSYEQV 1950
NTQAGQVWYP DSSFKTAQAI ADFNNGEELP LMILANWRGF SGGMRDMFDE 2000
ILKFGSMIVD NLRNYKQPVM VYIPPFAELR GGAWVVLDST INLDMMEMYC 2050
SEEGRGGVLE PNGIAEIKYR DPELIKTMHR LDPKLIEWDK SIPIGVSVNG 2100
LDQSQKTIKS QIQQREKELL GIYQQIAIKF ADLHDTPGRM KAKGVIKQMV 2150
PWKSARSFFY DRIKRRLFEE DKLKLIDKSH PGLNRQSKLN LLETWIKQIL 2200
GNNQSVDYHQ NDKLISSTIE SNSHIINDKI IDLSKQYAIN QILNFVQSDS 2250
ESIVDGFQNL LPFISTQQKE FLFESLKKDL NK 2282
Length:2,282
Mass (Da):256,735
Last modified:May 24, 2005 - v1
Checksum:iBDBEA99629EE1B2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000111 Genomic DNA. Translation: EAL63219.1.
RefSeqiXP_636722.1. XM_631630.1.

Genome annotation databases

EnsemblProtistsiDDB0230067; DDB0230067; DDB_G0288387.
GeneIDi8626599.
KEGGiddi:DDB_G0288387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000111 Genomic DNA. Translation: EAL63219.1 .
RefSeqi XP_636722.1. XM_631630.1.

3D structure databases

ProteinModelPortali Q54J08.
SMRi Q54J08. Positions 4-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0230067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0230067 ; DDB0230067 ; DDB_G0288387 .
GeneIDi 8626599.
KEGGi ddi:DDB_G0288387.

Organism-specific databases

dictyBasei DDB_G0288387. accA.

Phylogenomic databases

eggNOGi COG0511.
KOi K11262.
OMAi CERIEEN.
PhylomeDBi Q54J08.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .

Miscellaneous databases

PROi Q54J08.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProi IPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiACAC_DICDI
AccessioniPrimary (citable) accession number: Q54J08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3