Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable polyketide synthase 26

Gene

pks26

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable polyketide synthase.By similarity

Miscellaneous

Encoded by one of the numerous copies of polyketide synthase genes localized in chromosome 5.

Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei174For beta-ketoacyl synthase activityBy similarity1
Active sitei630For acyl/malonyl transferase activityBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-DDI-163765 ChREBP activates metabolic gene expression
R-DDI-199220 Vitamin B5 (pantothenate) metabolism
R-DDI-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable polyketide synthase 26 (EC:2.3.1.-)
Short name:
dipks26
Gene namesi
Name:pks26
ORF Names:DDB_G0288457
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288457 pks26

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003713881 – 2531Probable polyketide synthase 26Add BLAST2531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2468O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiQ54IX3
PRIDEiQ54IX3

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235218

Structurei

3D structure databases

ProteinModelPortaliQ54IX3
SMRiQ54IX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2431 – 2509CarrierPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 208Beta-ketoacyl synthaseAdd BLAST54
Regioni620 – 653Acyl/malonyl transferaseAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi436 – 442Poly-Asn7

Domaini

Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity

Phylogenomic databases

eggNOGiKOG1202 Eukaryota
ENOG410XNPJ LUCA
InParanoidiQ54IX3
PhylomeDBiQ54IX3

Family and domain databases

Gene3Di3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 2 hits
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit

Sequencei

Sequence statusi: Complete.

Q54IX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNNNKNIQ EDIAIIGFRI PGCQDNTPSE LWNNLMNKFS GVGKTTERWS
60 70 80 90 100
DNYHLSGDIN NGNSGLLPLK EWKKFDPAFF GINPTMVSTI DPQQRILLKC
110 120 130 140 150
TWEALEDAGI DPIKLRGSNT SIFIGCSTGD YLDMVKSNNE IQTNLFGSVN
160 170 180 190 200
HSLSNRISYC FDFHGASMTI DSACSSSLNT VLLGCQSINQ GKSNLCIAGG
210 220 230 240 250
VNFILDTTIP TAFSFLNILS KNGKCMTYDE GADGFVRGEG AGLVVLKSLK
260 270 280 290 300
DAIKDGNNIY CIIKGGNTNV DGNGNADKAN FFQPSKQSQS DNIKLALESI
310 320 330 340 350
KKKSMLDIDI DYVETHGTGT PTGDPIEVEG ISKVFKENHS PENPLLIGSL
360 370 380 390 400
KSNIGHMEAA SGVTSLIKCC LMFKNKSFAP NVNFQKINPK IKLDEWNIKV
410 420 430 440 450
VTEAIPFKKN KITSMVVNSF GVTGSNCCLV LTESINNNNN SNVDKITKNE
460 470 480 490 500
KEYLIPFSAN SNQSLKNYIE EVSKIDESLQ FEDFVYKQLS NKSTSLFQRF
510 520 530 540 550
VVTSKDWKEL KYKLSQPLPL KEISSSISVK KPNPITVFVF CGQGSQFNKM
560 570 580 590 600
GLELYNNDKN FRNYIDRFDK KLLEYYGYSV ISKLRSIDDN DLITIHDPII
610 620 630 640 650
AQPATAILQI SLFELYKHWG INPSFIVGHS LGELPMAFCS GMIDFDTVCY
660 670 680 690 700
LLYHRSLAQS KTNGCGKMLS CNISSEEFVK NYSPRYPFLE IACYNSPNSI
710 720 730 740 750
VVAGKESILL ELSKEFKNSG IFCAMLGSLS SFHTSSQLEV KDHIYSLKFE
760 770 780 790 800
SKEPVIPTFS TVTTHLFNSN KLYDNDYIFQ NIMKPVLFNE TISNLYKHVE
810 820 830 840 850
NNQLGSEMIF IELAPHQTLS FYLKQLIPKD SNYFSNSNSI TILSPLHKKK
860 870 880 890 900
NDYLEIQQTI STCYCKGYDV NFKSQILIES KTNISNKSLP LYQWDDKEFW
910 920 930 940 950
KDLEKQKRIL QGPPMDTLGF SNEKSPILKS FETKIDIKKK PFQYLKGHIV
960 970 980 990 1000
KGKIYFPGVG YIENLLKMYP SQDIDIDSME FEAPLILIEG IVTCLQSNVY
1010 1020 1030 1040 1050
KIGKNEFKVQ FHFQDQKTKQ WIQSSFANYH LSHRDDFDPT TNKLNIQNLI
1060 1070 1080 1090 1100
SNNCNLTKLS KNQFYNFIKA KAGLSYNGEF QGVEKCYLGD NCSLVEIPFD
1110 1120 1130 1140 1150
TSNQDVETNI NMIPILDSCL HGVHILYVEQ CQMVLEKIEG LKYYSSTLIL
1160 1170 1180 1190 1200
SKQKEQQKLY VFTRIENKDL INNSISASII VMISDGTVFF EIESVSLKSL
1210 1220 1230 1240 1250
IPLKDPISIE NPTDELFSSY LQSIDSLISE PSSYKSIYKR NEFISSGMSD
1260 1270 1280 1290 1300
LSRSDYQQFI STLLYTNLIK RNQSIESDLR NQIEFEEIKA KYCKNSKFER
1310 1320 1330 1340 1350
LFTFVIETIK QYDGINGNLN SWNEGNIDIY KILIKSTRII SKLLFPLQGE
1360 1370 1380 1390 1400
DTTIDTPQSL FENNLLDDFY NINGNTVIQN QLVGEIITQS IKPLINEKMV
1410 1420 1430 1440 1450
FRILEFGGGV GSLSIVTLNK INQLLEQHPN FQIDIEYTWT DISPSFIPDA
1460 1470 1480 1490 1500
KKLLSNIKGV TIIYRSLDLE ESLIEKQLLK PSYYDFVIMS NVLHVIKEIK
1510 1520 1530 1540 1550
FGIDEIYKVL SPNGQLLFIE TPYRMLICDS IFGVFDQWWG FTDTGIRVDR
1560 1570 1580 1590 1600
CCMKQKTWFK LLSESNYQDI IMSDDIKDCC FVIQAKKPSI SSLEYKLKID
1610 1620 1630 1640 1650
SQENDKIIVF GENDTFMKYL ENKSTKQIIK IKTCQQFSDL ITSNSKEINN
1660 1670 1680 1690 1700
QSIIYFIKTL NQLLIENFKE ITLEYIQINQ LLLSSGLSCK HILLLNQSTS
1710 1720 1730 1740 1750
ENYLGSSISG AARYFDEFPP LKLYSFDFDK YSLNNESINI IDDIIEPIIK
1760 1770 1780 1790 1800
SMNNSNIRKE LLVRNNKIFF ERYKQEKRIK ENYKSTSFEN DKSLFVHLNA
1810 1820 1830 1840 1850
NLEYELKSKQ VKLKQNEIEV NVKATGINYK DYLVYTAMTP SELINHKGES
1860 1870 1880 1890 1900
NPEFGHDFSG IITRIGDDDG DNDNEFKVGD QVYGIWFNTT ASHIIVDKEF
1910 1920 1930 1940 1950
LCHKPSKLSH TIASSIPVVY ITSLYSLYNI GNIQNDESIL IHSASGGIGL
1960 1970 1980 1990 2000
SALNILKWKN HKSHIFVTVG SKEKEKYIHD TYGDFITGIY SSRNKDYLKL
2010 2020 2030 2040 2050
IKRKLTELGS NKKGVDIILN TLSSSEHMVS NFKCLNHRGR IIDLSITHLN
2060 2070 2080 2090 2100
HNEYTCNNNF KYNYGYHNVE VLFVKGDIIS KLLKNITSAI ENGSLSTGIP
2110 2120 2130 2140 2150
IIEFNDSDCF NAIEFINKRQ HIGKIVVNHN KENLIQELIK KTNLPIIKSN
2160 2170 2180 2190 2200
YQINSDHLGK NILVTGQSGI ILEILKWIVK YSTNVENIII LSRSSLKWEL
2210 2220 2230 2240 2250
ELLVNKNKNK LNFIYKSVDV GNSLEIEKVI DEILMENPQI NNVDSIFHYA
2260 2270 2280 2290 2300
FTQISCKEHE IDQVHLNVSH QAKTMGAINL HNQSIKRNWK LINFIMASSA
2310 2320 2330 2340 2350
AGLIGSTDQC SYVCSSNVLD TFSKYRKHVL GLPSICINYG LIESTGFVSR
2360 2370 2380 2390 2400
NQSVAVMLDG QGIRPMQTNQ ILGSLDLFIQ NPSKSTNIIL TSFNFNEFAT
2410 2420 2430 2440 2450
GNLQQSNVHK FDFQFNCCLS QKSKLMANNQ ASENPVKDLL INNICELLSI
2460 2470 2480 2490 2500
DESKLNIDIR LIDYGSDSLT IVQIKNLIDK NLLIPNLISI QMLQNNSISD
2510 2520 2530
NIKILTDSYN KKKQNEQNEL KNIKVGSFTK K
Length:2,531
Mass (Da):287,781
Last modified:May 24, 2005 - v1
Checksum:i017B776B3C5E8124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000111 Genomic DNA Translation: EAL63254.1
RefSeqiXP_636757.1, XM_631665.1

Genome annotation databases

EnsemblProtistsiEAL63254; EAL63254; DDB_G0288457
GeneIDi8626635
KEGGiddi:DDB_G0288457

Similar proteinsi

Entry informationi

Entry nameiPKS26_DICDI
AccessioniPrimary (citable) accession number: Q54IX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health