Reviewed, UniProtKB/Swiss-Prot Q54IU9 (ARY1_DICDI)

Names and origin

Protein names

Recommended name:
    Probable arylamine N-acetyltransferase 1
    EC=2.3.1.5
Alternative name(s):
    Arylamide acetylase 1
    N-acetyltransferase type 1
      Short name=NAT-1

Gene names

ORF Names:

DDB_G0288503

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Probable arylamine N-acetyltransferase 1		PRO_0000327944
Sites
	Active site	72	1	Acyl-thioester intermediate By similarity
	Active site	112	1	By similarity
	Active site	127	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54IU9-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: C79C23FFE8B92210	FASTA	325	37,294
	10 20 30 40 50 60 MNPFTDYQVQ FFERIKLKPR IIESLDDISE VLVACSKVFT FENLDIISNT QEALTRKVLI 70 80 90 100 110 120 KQVLINKQGG LCYKANTLLY YFLLDFGLNV HQTRATCENQ ESHSRWNIGH GHMINILNFE 130 140 150 160 170 180 NKLYVMDVAF GCNLSLRPVP ITDDGSEVIE SCIGLYRVIK RENIVAGVYH YTHILEHRKP 190 200 210 220 230 240 DTYLIESAKN WVIGYAFDPL LICKNDGDDD DDDNNNNNNT HQTQIQQLVI DDPNKDFCVK 250 260 270 280 290 300 PLATKLINNT DNNNNNNSIA TLTLNSFTLT NCKTGEKIKT NFDNDNLFEQ FNQHLISIFN 310 320 LPPLKIIPQI FLNQTSNFPI NNLNS

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000112 Genomic DNA. Translation: EAL63200.1.
RefSeq	XP_636704.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3388277.
KEGG	ddi:DDBDRAFT_0219352.
Organism-specific databases
dictyBase	DDB_G0288503.
Enzyme and pathway databases
BRENDA	2.3.1.5. 424.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
ProDom	PD002783. Acetyltransf2. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARY1_DICDI

Accession

Primary (citable) accession number: Q54IU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	March 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)