Reviewed, UniProtKB/Swiss-Prot Q54IU8 (ARY2_DICDI)

Names and origin

Protein names

Recommended name:
    Probable arylamine N-acetyltransferase 2
    EC=2.3.1.5
Alternative name(s):
    Arylamide acetylase 2
    N-acetyltransferase type 2
      Short name=NAT-2

Gene names

ORF Names:

DDB_G0288507

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Probable arylamine N-acetyltransferase 2		PRO_0000327945
Sites
	Active site	75	1	Acyl-thioester intermediate By similarity
	Active site	115	1	By similarity
	Active site	130	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54IU8-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 9852A18C3D1F29EC	FASTA	299	34,522
	10 20 30 40 50 60 MEPNPIFSEF QLEFFKRIKM QPKSIETLND VSEVMSGCAQ IFSFENLDVV ANTTEPLNRE 70 80 90 100 110 120 VIIQQLVNNK QGGLCYKINS VFYYFIKSFG FNIYQVRCCV ENQETHDCWQ INGAHIINII 130 140 150 160 170 180 EYENKKYLAD VAFGCNLSYE PIPFSEEIIE SCTGLYRIRK VDNIIRDIKY TYLLEFKKPD 190 200 210 220 230 240 SFSPESARLW TNGYAFDPLV KAIDIDENDK IDSHATQIQQ LIIDDPTKEF SVKPLATKVV 250 260 270 280 290 NNESIATLTS NSFTLTNCKT GEKTKVTFDI NNEIKQLEQF NQHLISIFNL PPLKFLPKI

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000113 Genomic DNA. Translation: EAL63187.1.
RefSeq	XP_636690.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3388264.
KEGG	ddi:DDBDRAFT_0187966.
Organism-specific databases
dictyBase	DDB_G0288507.
Enzyme and pathway databases
BRENDA	2.3.1.5. 424.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProDom	PD002783. Acetyltransf2. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARY2_DICDI

Accession

Primary (citable) accession number: Q54IU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	March 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)