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Protein

Probable flavin-containing monoamine oxidase A

Gene

maoA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FADBy similarity

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-DDI-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
R-DDI-181430 Norepinephrine Neurotransmitter Release Cycle
R-DDI-379397 Enzymatic degradation of dopamine by COMT
R-DDI-379398 Enzymatic degradation of Dopamine by monoamine oxidase
R-DDI-380612 Metabolism of serotonin

Names & Taxonomyi

Protein namesi
Recommended name:
Probable flavin-containing monoamine oxidase A (EC:1.4.3.4)
Gene namesi
Name:maoA
ORF Names:DDB_G0288541
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288541 maoA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286281 – 456Probable flavin-containing monoamine oxidase AAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei394S-8alpha-FAD cysteineBy similarity1

Proteomic databases

PaxDbiQ54IT3

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231707

Structurei

3D structure databases

ProteinModelPortaliQ54IT3
SMRiQ54IT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
InParanoidiQ54IT3
KOiK00274
OMAiPWKAPLA
PhylomeDBiQ54IT3

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Q54IT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLYDVVIV GGGLTGLNAA YQFKKAGLNV MVLKPKDRFG GRTESIKVED
60 70 80 90 100
YWFDLGGQWM GGTHKYLKEL CDELGVKSFP QYDEGKHVLE INGKKVYYQG
110 120 130 140 150
NISNLNKSYN LEGLFESISK IDELSAELNP DKPYAHSKSK EYDQLTVAQW
160 170 180 190 200
VEKNVKGNDA RSIIDWFCRV CVAAEPTEVS FLFFLHFIRT AGNYGLLADI
210 220 230 240 250
HGGAQQDRLI GGSQQISEGL AKKIGEKHYT LNAPVRSIIQ DANQCTIKTD
260 270 280 290 300
NGSTYRSKYI VVAIPPTLAG RIHYSPSMPP RRDELTQRMP MGSVIKTITI
310 320 330 340 350
YDEPFWRKEG YSAEAISDKG PIFICYDDSS HDDKKTAIVG FIAASAAKDW
360 370 380 390 400
AEKSPEERKR AVLDCYARWW GPKALSPRIF LEKSWKEEEY SRGCYLGYTS
410 420 430 440 450
PGTLYQCGEH LRAPVGRIHW AGTETASVWI GYMEGALESG FRVSKEIKDK

LLNSKL
Length:456
Mass (Da):51,259
Last modified:May 24, 2005 - v1
Checksum:iE97522D45FFE9F43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000115 Genomic DNA Translation: EAL63176.1
RefSeqiXP_636677.1, XM_631585.1

Genome annotation databases

EnsemblProtistsiEAL63176; EAL63176; DDB_G0288541
GeneIDi8626677
KEGGiddi:DDB_G0288541

Similar proteinsi

Entry informationi

Entry nameiAOFA_DICDI
AccessioniPrimary (citable) accession number: Q54IT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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