Reviewed, UniProtKB/Swiss-Prot Q54IT3 (AOFA_DICDI)

Names and origin

Protein names

Recommended name:
    Probable flavin-containing monoamine oxidase A
    EC=1.4.3.4

Gene names

Name:	maoA
ORF Names:	DDB_G0288541

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.
Cofactor	FAD By similarity.
Sequence similarities	Belongs to the flavin monoamine oxidase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amine oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Probable flavin-containing monoamine oxidase A		PRO_0000328628
Amino acid modifications
	Modified residue	394	1	S-8alpha-FAD cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54IT3-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: E97522D45FFE9F43	FASTA	456	51,259
	10 20 30 40 50 60 MSTLYDVVIV GGGLTGLNAA YQFKKAGLNV MVLKPKDRFG GRTESIKVED YWFDLGGQWM 70 80 90 100 110 120 GGTHKYLKEL CDELGVKSFP QYDEGKHVLE INGKKVYYQG NISNLNKSYN LEGLFESISK 130 140 150 160 170 180 IDELSAELNP DKPYAHSKSK EYDQLTVAQW VEKNVKGNDA RSIIDWFCRV CVAAEPTEVS 190 200 210 220 230 240 FLFFLHFIRT AGNYGLLADI HGGAQQDRLI GGSQQISEGL AKKIGEKHYT LNAPVRSIIQ 250 260 270 280 290 300 DANQCTIKTD NGSTYRSKYI VVAIPPTLAG RIHYSPSMPP RRDELTQRMP MGSVIKTITI 310 320 330 340 350 360 YDEPFWRKEG YSAEAISDKG PIFICYDDSS HDDKKTAIVG FIAASAAKDW AEKSPEERKR 370 380 390 400 410 420 AVLDCYARWW GPKALSPRIF LEKSWKEEEY SRGCYLGYTS PGTLYQCGEH LRAPVGRIHW 430 440 450 AGTETASVWI GYMEGALESG FRVSKEIKDK LLNSKL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000115 Genomic DNA. Translation: EAL63176.1.
RefSeq	XP_636677.1.
3D structure databases
HSSP	HSSP built from PDB template 2BXR based on UniProtKB P21397.
SMR	Q54IT3. Positions 5-451.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54IT3.
Genome annotation databases
GeneID	8626677.
KEGG	ddi:DDB_0231707.
Organism-specific databases
dictyBase	DDB_G0288541. maoA.
Phylogenomic databases
eggNOG	KOG0029.
HOGENOM	HBG556224.
OMA	DENHANH.
PhylomeDB	Q54IT3.
Enzyme and pathway databases
BRENDA	1.4.3.4. 424.
Family and domain databases
InterPro	IPR001613. Amineoxid_fl. IPR002937. Amino_oxidase. [Graphical view]
Pfam	PF01593. Amino_oxidase. 1 hit. [Graphical view]
PRINTS	PR00757. AMINEOXDASEF.
ProtoNet	Search...

Entry information

Entry name

AOFA_DICDI

Accession

Primary (citable) accession number: Q54IT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)