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Protein

Probable flavin-containing monoamine oxidase A

Gene

maoA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-DDI-141333. Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.
R-DDI-181430. Norepinephrine Neurotransmitter Release Cycle.
R-DDI-379397. Enzymatic degradation of dopamine by COMT.
R-DDI-379398. Enzymatic degradation of Dopamine by monoamine oxidase.
R-DDI-380612. Metabolism of serotonin.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable flavin-containing monoamine oxidase A (EC:1.4.3.4)
Gene namesi
Name:maoA
ORF Names:DDB_G0288541
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288541. maoA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Probable flavin-containing monoamine oxidase APRO_0000328628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei394 – 3941S-8alpha-FAD cysteineBy similarity

Proteomic databases

PaxDbiQ54IT3.
PRIDEiQ54IT3.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231707.

Structurei

3D structure databases

ProteinModelPortaliQ54IT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
InParanoidiQ54IT3.
KOiK00274.
OMAiWKEEEYS.
PhylomeDBiQ54IT3.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q54IT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLYDVVIV GGGLTGLNAA YQFKKAGLNV MVLKPKDRFG GRTESIKVED
60 70 80 90 100
YWFDLGGQWM GGTHKYLKEL CDELGVKSFP QYDEGKHVLE INGKKVYYQG
110 120 130 140 150
NISNLNKSYN LEGLFESISK IDELSAELNP DKPYAHSKSK EYDQLTVAQW
160 170 180 190 200
VEKNVKGNDA RSIIDWFCRV CVAAEPTEVS FLFFLHFIRT AGNYGLLADI
210 220 230 240 250
HGGAQQDRLI GGSQQISEGL AKKIGEKHYT LNAPVRSIIQ DANQCTIKTD
260 270 280 290 300
NGSTYRSKYI VVAIPPTLAG RIHYSPSMPP RRDELTQRMP MGSVIKTITI
310 320 330 340 350
YDEPFWRKEG YSAEAISDKG PIFICYDDSS HDDKKTAIVG FIAASAAKDW
360 370 380 390 400
AEKSPEERKR AVLDCYARWW GPKALSPRIF LEKSWKEEEY SRGCYLGYTS
410 420 430 440 450
PGTLYQCGEH LRAPVGRIHW AGTETASVWI GYMEGALESG FRVSKEIKDK

LLNSKL
Length:456
Mass (Da):51,259
Last modified:May 24, 2005 - v1
Checksum:iE97522D45FFE9F43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000115 Genomic DNA. Translation: EAL63176.1.
RefSeqiXP_636677.1. XM_631585.1.

Genome annotation databases

EnsemblProtistsiDDB0231707; DDB0231707; DDB_G0288541.
GeneIDi8626677.
KEGGiddi:DDB_G0288541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000115 Genomic DNA. Translation: EAL63176.1.
RefSeqiXP_636677.1. XM_631585.1.

3D structure databases

ProteinModelPortaliQ54IT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231707.

Proteomic databases

PaxDbiQ54IT3.
PRIDEiQ54IT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231707; DDB0231707; DDB_G0288541.
GeneIDi8626677.
KEGGiddi:DDB_G0288541.

Organism-specific databases

dictyBaseiDDB_G0288541. maoA.

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
InParanoidiQ54IT3.
KOiK00274.
OMAiWKEEEYS.
PhylomeDBiQ54IT3.

Enzyme and pathway databases

ReactomeiR-DDI-141333. Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.
R-DDI-181430. Norepinephrine Neurotransmitter Release Cycle.
R-DDI-379397. Enzymatic degradation of dopamine by COMT.
R-DDI-379398. Enzymatic degradation of Dopamine by monoamine oxidase.
R-DDI-380612. Metabolism of serotonin.

Miscellaneous databases

PROiQ54IT3.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAOFA_DICDI
AccessioniPrimary (citable) accession number: Q54IT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: December 9, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.