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Q54IL7 (P5CR1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyrroline-5-carboxylate reductase 1

Short name=P5C reductase 1
Short name=P5CR 1
EC=1.5.1.2
Gene names
Name:pycr1
ORF Names:DDB_G0288671
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Subunit structure

Homodecamer; composed of 5 homodimers By similarity.

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-proline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyrroline-5-carboxylate reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Pyrroline-5-carboxylate reductase 1
PRO_0000328304

Regions

Compositional bias297 – 38892His-rich
Compositional bias319 – 3268Poly-Gln
Compositional bias448 – 4536Poly-Gln
Compositional bias456 – 47419Poly-Gln
Compositional bias487 – 49610Poly-Gln
Compositional bias504 – 53229Asn-rich

Sequences

Sequence LengthMass (Da)Tools
Q54IL7 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 6D15ED4680D6244D

FASTA55163,009
        10         20         30         40         50         60 
MKLYDNGVAV LGCGNLGNAI AKGLVASKQF KSNQIVLTKR NLSTIEPLKR EGYHVTTSNH 

        70         80         90        100        110        120 
DAVSRCKIVI VCVVPAQLDD LLDSIKQSVT ENHIIISVVS GASIEDIRSH LEKDVPIVRA 

       130        140        150        160        170        180 
MPNTAIQHCQ SMTCLAIRSS HQKSTNSPSD KAKDNALEVA KKIFNCLGMS IVLSEEQIVP 

       190        200        210        220        230        240 
ATALCACGIA FFCRAIRAAA QGGCEIGFHA EDAIRIAAQT AKGAATLLLE NNFHPEYEID 

       250        260        270        280        290        300 
KVTTPQGCTI AGLNQMEHAG FSSAMIKGIV TSSDKAASLY TQKQQNKKQQ QLKQQQHQQH 

       310        320        330        340        350        360 
QHQQHQQHQQ QVQQQEPHQY QQQQQQSHQQ SQYNQGHNYG HQNQHHHNHD DQHQNYYNQD 

       370        380        390        400        410        420 
QKRRNNRKHR SNENYDNHHH HNQQYQQHQQ PTQQESQEQT QQPEQTQSTN QSNQRRNSES 

       430        440        450        460        470        480 
RNGKSPQKQP QKQSQVQQPS STTENTDQQQ QQQPPQEQQQ QQEQPQQPQE QQQQPNVVDE 

       490        500        510        520        530        540 
AERPKEQQQQ PQQQQQTIDK KGYNNNRRGG RHYSYNNNYN SHHHRHNGIN KNSSSMYHDE 

       550 
KRHEVKTEQI N 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000119 Genomic DNA. Translation: EAL63112.1.

3D structure databases

ProteinModelPortalQ54IL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0232206.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0232206; DDB0232206; DDB_G0288671.
KEGGddi:DDB_G0288671.

Organism-specific databases

dictyBaseDDB_G0288671.

Phylogenomic databases

eggNOGCOG0345.
PhylomeDBQ54IL7.
ProtClustDBCLSZ2429861.

Enzyme and pathway databases

UniPathwayUPA00098; UER00361.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERPTHR11645. PTHR11645. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP5CR1_DICDI
AccessionPrimary (citable) accession number: Q54IL7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase