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Protein

Pyrroline-5-carboxylate reductase 1

Gene

pycr1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway:iL-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Pyrroline-5-carboxylate reductase 1 (pycr1), Pyrroline-5-carboxylate reductase 2 (pycr2)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_313802. Amino acid synthesis and interconversion (transamination).
UniPathwayiUPA00098; UER00361.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroline-5-carboxylate reductase 1 (EC:1.5.1.2)
Short name:
P5C reductase 1
Short name:
P5CR 1
Gene namesi
Name:pycr1
ORF Names:DDB_G0288671
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Pyrroline-5-carboxylate reductase 1PRO_0000328304Add
BLAST

Interactioni

Subunit structurei

Homodecamer; composed of 5 homodimers.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232206.

Structurei

3D structure databases

ProteinModelPortaliQ54IL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi297 – 38892His-richAdd
BLAST
Compositional biasi319 – 3268Poly-Gln
Compositional biasi448 – 4536Poly-Gln
Compositional biasi456 – 47419Poly-GlnAdd
BLAST
Compositional biasi487 – 49610Poly-Gln
Compositional biasi504 – 53229Asn-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0345.
InParanoidiQ54IL7.
KOiK00286.
PhylomeDBiQ54IL7.

Family and domain databases

Gene3Di1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01925. P5C_reductase.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54IL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYDNGVAV LGCGNLGNAI AKGLVASKQF KSNQIVLTKR NLSTIEPLKR
60 70 80 90 100
EGYHVTTSNH DAVSRCKIVI VCVVPAQLDD LLDSIKQSVT ENHIIISVVS
110 120 130 140 150
GASIEDIRSH LEKDVPIVRA MPNTAIQHCQ SMTCLAIRSS HQKSTNSPSD
160 170 180 190 200
KAKDNALEVA KKIFNCLGMS IVLSEEQIVP ATALCACGIA FFCRAIRAAA
210 220 230 240 250
QGGCEIGFHA EDAIRIAAQT AKGAATLLLE NNFHPEYEID KVTTPQGCTI
260 270 280 290 300
AGLNQMEHAG FSSAMIKGIV TSSDKAASLY TQKQQNKKQQ QLKQQQHQQH
310 320 330 340 350
QHQQHQQHQQ QVQQQEPHQY QQQQQQSHQQ SQYNQGHNYG HQNQHHHNHD
360 370 380 390 400
DQHQNYYNQD QKRRNNRKHR SNENYDNHHH HNQQYQQHQQ PTQQESQEQT
410 420 430 440 450
QQPEQTQSTN QSNQRRNSES RNGKSPQKQP QKQSQVQQPS STTENTDQQQ
460 470 480 490 500
QQQPPQEQQQ QQEQPQQPQE QQQQPNVVDE AERPKEQQQQ PQQQQQTIDK
510 520 530 540 550
KGYNNNRRGG RHYSYNNNYN SHHHRHNGIN KNSSSMYHDE KRHEVKTEQI

N
Length:551
Mass (Da):63,009
Last modified:May 24, 2005 - v1
Checksum:i6D15ED4680D6244D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000119 Genomic DNA. Translation: EAL63112.1.
RefSeqiXP_636614.1. XM_631522.1.

Genome annotation databases

EnsemblProtistsiDDB0232206; DDB0232206; DDB_G0288671.
GeneIDi8626742.
KEGGiddi:DDB_G0288671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000119 Genomic DNA. Translation: EAL63112.1.
RefSeqiXP_636614.1. XM_631522.1.

3D structure databases

ProteinModelPortaliQ54IL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0232206; DDB0232206; DDB_G0288671.
GeneIDi8626742.
KEGGiddi:DDB_G0288671.

Organism-specific databases

dictyBaseiDDB_G0288671.

Phylogenomic databases

eggNOGiCOG0345.
InParanoidiQ54IL7.
KOiK00286.
PhylomeDBiQ54IL7.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00361.
ReactomeiREACT_313802. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

PROiQ54IL7.

Family and domain databases

Gene3Di1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01925. P5C_reductase.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiP5CR1_DICDI
AccessioniPrimary (citable) accession number: Q54IL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.