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Q54IL7

- P5CR1_DICDI

UniProt

Q54IL7 - P5CR1_DICDI

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Protein
Pyrroline-5-carboxylate reductase 1
Gene
pycr1, DDB_G0288671
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathwayi

GO - Molecular functioni

  1. pyrroline-5-carboxylate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00361.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroline-5-carboxylate reductase 1 (EC:1.5.1.2)
Short name:
P5C reductase 1
Short name:
P5CR 1
Gene namesi
Name:pycr1
ORF Names:DDB_G0288671
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Pyrroline-5-carboxylate reductase 1
PRO_0000328304Add
BLAST

Interactioni

Subunit structurei

Homodecamer; composed of 5 homodimers By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0232206.

Structurei

3D structure databases

ProteinModelPortaliQ54IL7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi297 – 38892His-rich
Add
BLAST
Compositional biasi319 – 3268Poly-Gln
Compositional biasi448 – 4536Poly-Gln
Compositional biasi456 – 47419Poly-Gln
Add
BLAST
Compositional biasi487 – 49610Poly-Gln
Compositional biasi504 – 53229Asn-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0345.
OMAiKRYERIN.
PhylomeDBiQ54IL7.

Family and domain databases

Gene3Di1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01925. P5C_reductase.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54IL7-1 [UniParc]FASTAAdd to Basket

« Hide

MKLYDNGVAV LGCGNLGNAI AKGLVASKQF KSNQIVLTKR NLSTIEPLKR    50
EGYHVTTSNH DAVSRCKIVI VCVVPAQLDD LLDSIKQSVT ENHIIISVVS 100
GASIEDIRSH LEKDVPIVRA MPNTAIQHCQ SMTCLAIRSS HQKSTNSPSD 150
KAKDNALEVA KKIFNCLGMS IVLSEEQIVP ATALCACGIA FFCRAIRAAA 200
QGGCEIGFHA EDAIRIAAQT AKGAATLLLE NNFHPEYEID KVTTPQGCTI 250
AGLNQMEHAG FSSAMIKGIV TSSDKAASLY TQKQQNKKQQ QLKQQQHQQH 300
QHQQHQQHQQ QVQQQEPHQY QQQQQQSHQQ SQYNQGHNYG HQNQHHHNHD 350
DQHQNYYNQD QKRRNNRKHR SNENYDNHHH HNQQYQQHQQ PTQQESQEQT 400
QQPEQTQSTN QSNQRRNSES RNGKSPQKQP QKQSQVQQPS STTENTDQQQ 450
QQQPPQEQQQ QQEQPQQPQE QQQQPNVVDE AERPKEQQQQ PQQQQQTIDK 500
KGYNNNRRGG RHYSYNNNYN SHHHRHNGIN KNSSSMYHDE KRHEVKTEQI 550
N 551
Length:551
Mass (Da):63,009
Last modified:May 24, 2005 - v1
Checksum:i6D15ED4680D6244D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000119 Genomic DNA. Translation: EAL63112.1.
RefSeqiXP_636614.1. XM_631522.1.

Genome annotation databases

EnsemblProtistsiDDB0232206; DDB0232206; DDB_G0288671.
GeneIDi8626742.
KEGGiddi:DDB_G0288671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000119 Genomic DNA. Translation: EAL63112.1 .
RefSeqi XP_636614.1. XM_631522.1.

3D structure databases

ProteinModelPortali Q54IL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0232206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0232206 ; DDB0232206 ; DDB_G0288671 .
GeneIDi 8626742.
KEGGi ddi:DDB_G0288671.

Organism-specific databases

dictyBasei DDB_G0288671.

Phylogenomic databases

eggNOGi COG0345.
OMAi KRYERIN.
PhylomeDBi Q54IL7.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00361 .

Family and domain databases

Gene3Di 1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_01925. P5C_reductase.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view ]
PANTHERi PTHR11645. PTHR11645. 1 hit.
Pfami PF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiP5CR1_DICDI
AccessioniPrimary (citable) accession number: Q54IL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3