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Q54IL7

- P5CR1_DICDI

UniProt

Q54IL7 - P5CR1_DICDI

Protein

Pyrroline-5-carboxylate reductase 1

Gene

pycr1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

    Pathwayi

    GO - Molecular functioni

    1. pyrroline-5-carboxylate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00098; UER00361.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrroline-5-carboxylate reductase 1 (EC:1.5.1.2)
    Short name:
    P5C reductase 1
    Short name:
    P5CR 1
    Gene namesi
    Name:pycr1
    ORF Names:DDB_G0288671
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0288671.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Pyrroline-5-carboxylate reductase 1PRO_0000328304Add
    BLAST

    Interactioni

    Subunit structurei

    Homodecamer; composed of 5 homodimers.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0232206.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54IL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi297 – 38892His-richAdd
    BLAST
    Compositional biasi319 – 3268Poly-Gln
    Compositional biasi448 – 4536Poly-Gln
    Compositional biasi456 – 47419Poly-GlnAdd
    BLAST
    Compositional biasi487 – 49610Poly-Gln
    Compositional biasi504 – 53229Asn-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0345.
    OMAiKRYERIN.
    PhylomeDBiQ54IL7.

    Family and domain databases

    Gene3Di1.10.3730.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_01925. P5C_reductase.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR029036. P5CR_dimer.
    IPR028939. ProC_N.
    IPR000304. Pyrroline-COOH_reductase.
    [Graphical view]
    PANTHERiPTHR11645. PTHR11645. 1 hit.
    PfamiPF03807. F420_oxidored. 1 hit.
    PF14748. P5CR_dimer. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54IL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLYDNGVAV LGCGNLGNAI AKGLVASKQF KSNQIVLTKR NLSTIEPLKR    50
    EGYHVTTSNH DAVSRCKIVI VCVVPAQLDD LLDSIKQSVT ENHIIISVVS 100
    GASIEDIRSH LEKDVPIVRA MPNTAIQHCQ SMTCLAIRSS HQKSTNSPSD 150
    KAKDNALEVA KKIFNCLGMS IVLSEEQIVP ATALCACGIA FFCRAIRAAA 200
    QGGCEIGFHA EDAIRIAAQT AKGAATLLLE NNFHPEYEID KVTTPQGCTI 250
    AGLNQMEHAG FSSAMIKGIV TSSDKAASLY TQKQQNKKQQ QLKQQQHQQH 300
    QHQQHQQHQQ QVQQQEPHQY QQQQQQSHQQ SQYNQGHNYG HQNQHHHNHD 350
    DQHQNYYNQD QKRRNNRKHR SNENYDNHHH HNQQYQQHQQ PTQQESQEQT 400
    QQPEQTQSTN QSNQRRNSES RNGKSPQKQP QKQSQVQQPS STTENTDQQQ 450
    QQQPPQEQQQ QQEQPQQPQE QQQQPNVVDE AERPKEQQQQ PQQQQQTIDK 500
    KGYNNNRRGG RHYSYNNNYN SHHHRHNGIN KNSSSMYHDE KRHEVKTEQI 550
    N 551
    Length:551
    Mass (Da):63,009
    Last modified:May 24, 2005 - v1
    Checksum:i6D15ED4680D6244D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000119 Genomic DNA. Translation: EAL63112.1.
    RefSeqiXP_636614.1. XM_631522.1.

    Genome annotation databases

    EnsemblProtistsiDDB0232206; DDB0232206; DDB_G0288671.
    GeneIDi8626742.
    KEGGiddi:DDB_G0288671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000119 Genomic DNA. Translation: EAL63112.1 .
    RefSeqi XP_636614.1. XM_631522.1.

    3D structure databases

    ProteinModelPortali Q54IL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0232206.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0232206 ; DDB0232206 ; DDB_G0288671 .
    GeneIDi 8626742.
    KEGGi ddi:DDB_G0288671.

    Organism-specific databases

    dictyBasei DDB_G0288671.

    Phylogenomic databases

    eggNOGi COG0345.
    OMAi KRYERIN.
    PhylomeDBi Q54IL7.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00361 .

    Family and domain databases

    Gene3Di 1.10.3730.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_01925. P5C_reductase.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR029036. P5CR_dimer.
    IPR028939. ProC_N.
    IPR000304. Pyrroline-COOH_reductase.
    [Graphical view ]
    PANTHERi PTHR11645. PTHR11645. 1 hit.
    Pfami PF03807. F420_oxidored. 1 hit.
    PF14748. P5CR_dimer. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiP5CR1_DICDI
    AccessioniPrimary (citable) accession number: Q54IL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3