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Protein

Glutamate decarboxylase B

Gene

gadB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Generates GABA from glutamate. Likely to be responsible for the metabolism of glutamate via the GABA shunt to succinate during growth.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateBy similarity1
Binding sitei81SubstrateBy similarity1
Binding sitei208Pyridoxal phosphateBy similarity1
Binding sitei271Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • aggregation involved in sorocarp development Source: dictyBase
  • glutamate catabolic process Source: dictyBase

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase B (EC:4.1.1.15)
Gene namesi
Name:gadB
ORF Names:DDB_G0288715
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288715 gadB

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003913301 – 463Glutamate decarboxylase BAdd BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ54IJ3
PRIDEiQ54IJ3

Expressioni

Developmental stagei

Expressed in growing cells, its mRNA continuously decreases during development. Highly expressed during phagocytosis of non-pathogenic bacteria.2 Publications

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231439

Structurei

3D structure databases

ProteinModelPortaliQ54IJ3
SMRiQ54IJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 123Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1383 Eukaryota
COG0076 LUCA
InParanoidiQ54IJ3
KOiK01580
OMAiFTTSVYG
PhylomeDBiQ54IJ3

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR010107 Glutamate_decarboxylase
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43321 PTHR43321, 1 hit
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01788 Glu-decarb-GAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q54IJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHIVDKHK SLYDNYVQSA TTEEIAKFKL ADDPNEPETI KKLIMDELLL
60 70 80 90 100
DGNSKQNLAT FCQTDLDKNI HSIMDKCIDK NMIDKDEYPQ SAEIENRCLH
110 120 130 140 150
ILADLWNAPD SSDTIGCSTT GSSEAAMLGG LALKWNWREN RKKLGLPYDK
160 170 180 190 200
PNIVTGPVQI CWHKFALYFD IEIREIPMEN GRYVMNSEEV LKRVDENTIG
210 220 230 240 250
VIPTLGVTFT LQYEDVFSIS NALDKFEKES GINIPIHVDA ASGGFVAPFI
260 270 280 290 300
QQEIIWDFRL PRVKSINASG HKFGLSPLGV GWVVWREKKD LHKDLVFNVN
310 320 330 340 350
YLGGNMSTFS LNFSRPGGQI IAQYYNFLRH GRNGYTLIQD ACAQQGIFIG
360 370 380 390 400
KELKKMGIFD LIYDGTGALP GVCWTISKNL PSEPLFNLYD LSEKLRSRGW
410 420 430 440 450
QVASYSLPSS MNDVVVSRVV IRHGFSRDLS SLFVKDVQNA IEYFQKHPIL
460
RSLEKDEGEN FHH
Length:463
Mass (Da):52,506
Last modified:May 24, 2005 - v1
Checksum:i8803CBD7A216B4E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000120 Genomic DNA Translation: EAL63089.1
RefSeqiXP_636593.1, XM_631501.1

Genome annotation databases

EnsemblProtistsiEAL63089; EAL63089; DDB_G0288715
GeneIDi8626767
KEGGiddi:DDB_G0288715

Similar proteinsi

Entry informationi

Entry nameiGADB_DICDI
AccessioniPrimary (citable) accession number: Q54IJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health