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Protein

Probable 2-methylcitrate dehydratase

Gene

prpD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate.By similarity

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.By similarity

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-methylcitrate dehydrataseBy similarity (EC:4.2.1.79By similarity)
Short name:
2-MC dehydrataseBy similarity
Alternative name(s):
(2S,3S)-2-methylcitrate dehydrataseBy similarity
Gene namesi
Name:prpD
ORF Names:DDB_G0288681
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288681. prpD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Probable 2-methylcitrate dehydratasePRO_0000328266Add
BLAST

Proteomic databases

PRIDEiQ54IJ0.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0191366.

Structurei

3D structure databases

ProteinModelPortaliQ54IJ0.
SMRiQ54IJ0. Positions 8-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.Curated

Phylogenomic databases

eggNOGiCOG2079.
InParanoidiQ54IJ0.
KOiK01720.
OMAiCLMDTLG.
PhylomeDBiQ54IJ0.

Family and domain databases

InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.
TIGRFAMsiTIGR02330. prpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54IJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNIEQKWD KVLEDIVDYV IGFDVEGNSK EAMETAFLAL FDTIGCGFLG
60 70 80 90 100
LKSTGCTKLM GPTIPDTRIP GGCRVPGTDY QLNPIEAAFN IGCMNRWLDF
110 120 130 140 150
NDCWLANEWG HPSDNISAII AAAEYISNDN ISKSKKPLLM KDILCAMVKC
160 170 180 190 200
YEIQGVLALD NSFNKIGLDH VILVKIASTA VTCHLLGGSR IQILNALSNA
210 220 230 240 250
FIDGHPLRTY RHSPNTGSRK GWAAGDAASR AVQLSLMAMA GEMGYPTCLS
260 270 280 290 300
APKWGFYHVY MSDKPFQFNQ RSNYSTYVME NILFKVLYPA EFHGQTAIEC
310 320 330 340 350
AIQLHPIFQD KGGLNSVESI TIETTEPAIR IIDKRGILRN PSDRDHCLQF
360 370 380 390 400
IVSVALIFGE LKSSHYEDQV AIKDTRIDLL REKITCIENL QFSLDYLNPD
410 420 430 440 450
KRSIANSITI LFKDGETHKH QIDYPIGHRN RRSEAIPLLQ QKFLNSLNST
460 470 480 490
LFTSSSIDQI KNLYENPSKF NNLSILDFMS IFSLSIASTP IS
Length:492
Mass (Da):54,984
Last modified:May 24, 2005 - v1
Checksum:iCE1B4F05C0C9821A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000120 Genomic DNA. Translation: EAL63072.1.
U83088 mRNA. Translation: AAB40931.1.
RefSeqiXP_636596.1. XM_631504.1.

Genome annotation databases

EnsemblProtistsiDDB0191366; DDB0191366; DDB_G0288681.
GeneIDi8626771.
KEGGiddi:DDB_G0288681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000120 Genomic DNA. Translation: EAL63072.1.
U83088 mRNA. Translation: AAB40931.1.
RefSeqiXP_636596.1. XM_631504.1.

3D structure databases

ProteinModelPortaliQ54IJ0.
SMRiQ54IJ0. Positions 8-483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0191366.

Proteomic databases

PRIDEiQ54IJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0191366; DDB0191366; DDB_G0288681.
GeneIDi8626771.
KEGGiddi:DDB_G0288681.

Organism-specific databases

dictyBaseiDDB_G0288681. prpD.

Phylogenomic databases

eggNOGiCOG2079.
InParanoidiQ54IJ0.
KOiK01720.
OMAiCLMDTLG.
PhylomeDBiQ54IJ0.

Enzyme and pathway databases

UniPathwayiUPA00946.

Miscellaneous databases

PROiQ54IJ0.

Family and domain databases

InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.
TIGRFAMsiTIGR02330. prpD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. Iranfar N., Loomis W.F.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 163-492.
    Strain: AX4.

Entry informationi

Entry nameiPRPD_DICDI
AccessioniPrimary (citable) accession number: Q54IJ0
Secondary accession number(s): P90535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 27, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.