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Q54IJ0

- PRPD_DICDI

UniProt

Q54IJ0 - PRPD_DICDI

Protein

Probable 2-methylcitrate dehydratase

Gene

prpD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate.By similarity

    Catalytic activityi

    (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 2-methylcitrate dehydratase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-methylcitrate dehydratase (EC:4.2.1.79)
    Gene namesi
    Name:prpD
    ORF Names:DDB_G0288681
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0288681. prpD.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Probable 2-methylcitrate dehydratasePRO_0000328266Add
    BLAST

    Proteomic databases

    PRIDEiQ54IJ0.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0191366.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54IJ0.
    SMRiQ54IJ0. Positions 8-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PrpD family.Curated

    Phylogenomic databases

    eggNOGiCOG2079.
    KOiK01720.
    OMAiFRREEGI.
    PhylomeDBiQ54IJ0.

    Family and domain databases

    InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
    IPR005656. MmgE_PrpD.
    [Graphical view]
    PANTHERiPTHR16943. PTHR16943. 1 hit.
    PfamiPF03972. MmgE_PrpD. 1 hit.
    [Graphical view]
    SUPFAMiSSF103378. SSF103378. 1 hit.
    TIGRFAMsiTIGR02330. prpD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54IJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNNIEQKWD KVLEDIVDYV IGFDVEGNSK EAMETAFLAL FDTIGCGFLG    50
    LKSTGCTKLM GPTIPDTRIP GGCRVPGTDY QLNPIEAAFN IGCMNRWLDF 100
    NDCWLANEWG HPSDNISAII AAAEYISNDN ISKSKKPLLM KDILCAMVKC 150
    YEIQGVLALD NSFNKIGLDH VILVKIASTA VTCHLLGGSR IQILNALSNA 200
    FIDGHPLRTY RHSPNTGSRK GWAAGDAASR AVQLSLMAMA GEMGYPTCLS 250
    APKWGFYHVY MSDKPFQFNQ RSNYSTYVME NILFKVLYPA EFHGQTAIEC 300
    AIQLHPIFQD KGGLNSVESI TIETTEPAIR IIDKRGILRN PSDRDHCLQF 350
    IVSVALIFGE LKSSHYEDQV AIKDTRIDLL REKITCIENL QFSLDYLNPD 400
    KRSIANSITI LFKDGETHKH QIDYPIGHRN RRSEAIPLLQ QKFLNSLNST 450
    LFTSSSIDQI KNLYENPSKF NNLSILDFMS IFSLSIASTP IS 492
    Length:492
    Mass (Da):54,984
    Last modified:May 24, 2005 - v1
    Checksum:iCE1B4F05C0C9821A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000120 Genomic DNA. Translation: EAL63072.1.
    U83088 mRNA. Translation: AAB40931.1.
    RefSeqiXP_636596.1. XM_631504.1.

    Genome annotation databases

    EnsemblProtistsiDDB0191366; DDB0191366; DDB_G0288681.
    GeneIDi8626771.
    KEGGiddi:DDB_G0288681.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000120 Genomic DNA. Translation: EAL63072.1 .
    U83088 mRNA. Translation: AAB40931.1 .
    RefSeqi XP_636596.1. XM_631504.1.

    3D structure databases

    ProteinModelPortali Q54IJ0.
    SMRi Q54IJ0. Positions 8-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0191366.

    Proteomic databases

    PRIDEi Q54IJ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0191366 ; DDB0191366 ; DDB_G0288681 .
    GeneIDi 8626771.
    KEGGi ddi:DDB_G0288681.

    Organism-specific databases

    dictyBasei DDB_G0288681. prpD.

    Phylogenomic databases

    eggNOGi COG2079.
    KOi K01720.
    OMAi FRREEGI.
    PhylomeDBi Q54IJ0.

    Enzyme and pathway databases

    UniPathwayi UPA00946 .

    Miscellaneous databases

    PROi Q54IJ0.

    Family and domain databases

    InterProi IPR012705. 2Me_IsoCit_deHydtase_PrpD.
    IPR005656. MmgE_PrpD.
    [Graphical view ]
    PANTHERi PTHR16943. PTHR16943. 1 hit.
    Pfami PF03972. MmgE_PrpD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103378. SSF103378. 1 hit.
    TIGRFAMsi TIGR02330. prpD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. Iranfar N., Loomis W.F.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 163-492.
      Strain: AX4.

    Entry informationi

    Entry nameiPRPD_DICDI
    AccessioniPrimary (citable) accession number: Q54IJ0
    Secondary accession number(s): P90535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3