SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q54IJ0

- PRPD_DICDI

UniProt

Q54IJ0 - PRPD_DICDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable 2-methylcitrate dehydratase
Gene
prpD, DDB_G0288681
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate By similarity.

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

Cofactori

Binds 1 2Fe-2S cluster By similarity.

Pathwayi

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 2-methylcitrate dehydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-methylcitrate dehydratase (EC:4.2.1.79)
Gene namesi
Name:prpD
ORF Names:DDB_G0288681
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288681. prpD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Probable 2-methylcitrate dehydratase
PRO_0000328266Add
BLAST

Proteomic databases

PRIDEiQ54IJ0.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0191366.

Structurei

3D structure databases

ProteinModelPortaliQ54IJ0.
SMRiQ54IJ0. Positions 8-483.

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.

Phylogenomic databases

eggNOGiCOG2079.
KOiK01720.
OMAiFRREEGI.
PhylomeDBiQ54IJ0.

Family and domain databases

InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.
TIGRFAMsiTIGR02330. prpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54IJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MNNNIEQKWD KVLEDIVDYV IGFDVEGNSK EAMETAFLAL FDTIGCGFLG    50
LKSTGCTKLM GPTIPDTRIP GGCRVPGTDY QLNPIEAAFN IGCMNRWLDF 100
NDCWLANEWG HPSDNISAII AAAEYISNDN ISKSKKPLLM KDILCAMVKC 150
YEIQGVLALD NSFNKIGLDH VILVKIASTA VTCHLLGGSR IQILNALSNA 200
FIDGHPLRTY RHSPNTGSRK GWAAGDAASR AVQLSLMAMA GEMGYPTCLS 250
APKWGFYHVY MSDKPFQFNQ RSNYSTYVME NILFKVLYPA EFHGQTAIEC 300
AIQLHPIFQD KGGLNSVESI TIETTEPAIR IIDKRGILRN PSDRDHCLQF 350
IVSVALIFGE LKSSHYEDQV AIKDTRIDLL REKITCIENL QFSLDYLNPD 400
KRSIANSITI LFKDGETHKH QIDYPIGHRN RRSEAIPLLQ QKFLNSLNST 450
LFTSSSIDQI KNLYENPSKF NNLSILDFMS IFSLSIASTP IS 492
Length:492
Mass (Da):54,984
Last modified:May 24, 2005 - v1
Checksum:iCE1B4F05C0C9821A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000120 Genomic DNA. Translation: EAL63072.1.
U83088 mRNA. Translation: AAB40931.1.
RefSeqiXP_636596.1. XM_631504.1.

Genome annotation databases

EnsemblProtistsiDDB0191366; DDB0191366; DDB_G0288681.
GeneIDi8626771.
KEGGiddi:DDB_G0288681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000120 Genomic DNA. Translation: EAL63072.1 .
U83088 mRNA. Translation: AAB40931.1 .
RefSeqi XP_636596.1. XM_631504.1.

3D structure databases

ProteinModelPortali Q54IJ0.
SMRi Q54IJ0. Positions 8-483.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191366.

Proteomic databases

PRIDEi Q54IJ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191366 ; DDB0191366 ; DDB_G0288681 .
GeneIDi 8626771.
KEGGi ddi:DDB_G0288681.

Organism-specific databases

dictyBasei DDB_G0288681. prpD.

Phylogenomic databases

eggNOGi COG2079.
KOi K01720.
OMAi FRREEGI.
PhylomeDBi Q54IJ0.

Enzyme and pathway databases

UniPathwayi UPA00946 .

Miscellaneous databases

PROi Q54IJ0.

Family and domain databases

InterProi IPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view ]
PANTHERi PTHR16943. PTHR16943. 1 hit.
Pfami PF03972. MmgE_PrpD. 1 hit.
[Graphical view ]
SUPFAMi SSF103378. SSF103378. 1 hit.
TIGRFAMsi TIGR02330. prpD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. Iranfar N., Loomis W.F.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 163-492.
    Strain: AX4.

Entry informationi

Entry nameiPRPD_DICDI
AccessioniPrimary (citable) accession number: Q54IJ0
Secondary accession number(s): P90535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi