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Q54IJ0 (PRPD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 2-methylcitrate dehydratase

EC=4.2.1.79
Gene names
Name:prpD
ORF Names:DDB_G0288681
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate By similarity.

Catalytic activity

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Pathway

Organic acid metabolism; propanoate degradation.

Sequence similarities

Belongs to the PrpD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Probable 2-methylcitrate dehydratase
PRO_0000328266

Sequences

Sequence LengthMass (Da)Tools
Q54IJ0 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: CE1B4F05C0C9821A

FASTA49254,984
        10         20         30         40         50         60 
MNNNIEQKWD KVLEDIVDYV IGFDVEGNSK EAMETAFLAL FDTIGCGFLG LKSTGCTKLM 

        70         80         90        100        110        120 
GPTIPDTRIP GGCRVPGTDY QLNPIEAAFN IGCMNRWLDF NDCWLANEWG HPSDNISAII 

       130        140        150        160        170        180 
AAAEYISNDN ISKSKKPLLM KDILCAMVKC YEIQGVLALD NSFNKIGLDH VILVKIASTA 

       190        200        210        220        230        240 
VTCHLLGGSR IQILNALSNA FIDGHPLRTY RHSPNTGSRK GWAAGDAASR AVQLSLMAMA 

       250        260        270        280        290        300 
GEMGYPTCLS APKWGFYHVY MSDKPFQFNQ RSNYSTYVME NILFKVLYPA EFHGQTAIEC 

       310        320        330        340        350        360 
AIQLHPIFQD KGGLNSVESI TIETTEPAIR IIDKRGILRN PSDRDHCLQF IVSVALIFGE 

       370        380        390        400        410        420 
LKSSHYEDQV AIKDTRIDLL REKITCIENL QFSLDYLNPD KRSIANSITI LFKDGETHKH 

       430        440        450        460        470        480 
QIDYPIGHRN RRSEAIPLLQ QKFLNSLNST LFTSSSIDQI KNLYENPSKF NNLSILDFMS 

       490 
IFSLSIASTP IS 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]Iranfar N., Loomis W.F.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 163-492.
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000120 Genomic DNA. Translation: EAL63072.1.
U83088 mRNA. Translation: AAB40931.1.
RefSeqXP_636596.1. XM_631504.1.

3D structure databases

ProteinModelPortalQ54IJ0.
SMRQ54IJ0. Positions 8-483.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0191366.

Proteomic databases

PRIDEQ54IJ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0191366; DDB0191366; DDB_G0288681.
GeneID8626771.
KEGGddi:DDB_G0288681.

Organism-specific databases

dictyBaseDDB_G0288681. prpD.

Phylogenomic databases

eggNOGCOG2079.
OMAFRREEGI.
PhylomeDBQ54IJ0.

Enzyme and pathway databases

UniPathwayUPA00946.

Family and domain databases

InterProIPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view]
PANTHERPTHR16943. PTHR16943. 1 hit.
PfamPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMSSF103378. SSF103378. 1 hit.
TIGRFAMsTIGR02330. prpD. 1 hit.
ProtoNetSearch...

Other

PROQ54IJ0.

Entry information

Entry namePRPD_DICDI
AccessionPrimary (citable) accession number: Q54IJ0
Secondary accession number(s): P90535
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase