Reviewed, UniProtKB/Swiss-Prot Q54IH6 (ABKA_DICDI)

Names and origin

Protein names

Recommended name:
    Probable serine/threonine-protein kinase abkA
    EC=2.7.11.-

Gene names

Name:	abkA
Synonyms:	adckA
ORF Names:	DDB_G0288749

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 565	565	Probable serine/threonine-protein kinase abkA		PRO_0000367576
Regions
	Domain	231 – 565	335	Protein kinase
	Nucleotide binding	237 – 245	9	ATP By similarity
	Coiled coil	44 – 77	34	Potential
	Compositional bias	42 – 47	6	Poly-Asn
	Compositional bias	72 – 79	8	Poly-Asp
	Compositional bias	141 – 153	13	Poly-Ser
Sites
	Active site	401	1	Proton acceptor By similarity
	Binding site	259	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54IH6-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 2AB2DD3CDF5EA3F4	FASTA	565	64,525
	10 20 30 40 50 60 MGGRLNDLIQ VAYGGKNVIL SMMKNKTRQT SSVFINNLNS LNNNNNNISL KDKFKDLKDL 70 80 90 100 110 120 KDNLNEKKIN NDNDDDDEDN LIFDEKKDFL NENKNPELNY IKSKGHKIPS SQTSRFWEFT 130 140 150 160 170 180 KLAVGVGAGF LGEKTKRTID SSSSSSSPSS SYSAIFTDTN AERMAESFSR MRGAALKIGQ 190 200 210 220 230 240 VLSIQDESFL PPKFVEILDR VRKNANPIPL EQLYNTMSNE LGENWRSKFQ LFQDDPIAAA 250 260 270 280 290 300 SIGQVHRAIT LDGKEVAVKV QYPGVADSIT SDIKNLSSLL KMIVPETAYI EKSLESARSE 310 320 330 340 350 360 LLLETDYLNE ASNQLKFKSL LESSINSGTN GSFKYLKDLY VPNVIMELTT KRILTTEFVH 370 380 390 400 410 420 GTSIDKITIE NHNQETRDWI SKNILSLCLA ELFEFNFMQV DPNWTNFVVD FENKRINLLD 430 440 450 460 470 480 FGACRNYKSE FLFNYLKSIE GGVNRDINQI LEYSLKLGYL TGDENKQMND AQAKSILILS 490 500 510 520 530 540 EPFSKLYYKE NNLKTYPFNE KQIAKRISQL IPTMLKNRLK PPPEETYSLH RKLSGCYLVC 550 560 SKLKSNINST LIFNHFKNIF YKNYK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The dictyostelium kinome -- analysis of the protein kinases from a simple model organism." Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L. PLoS Genet. 2:E38-E38(2006) [PubMed: 16596165] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000122 Genomic DNA. Translation: EAL63067.1.
RefSeq	XP_636572.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54IH6.
Genome annotation databases
GeneID	3388144.
GenomeReviews	Gene locus abkA in contig CM000154_GR.
KEGG	ddi:DDB_0216427.
Organism-specific databases
dictyBase	DDB_G0288749. abkA.
Phylogenomic databases
OMA	VLAMELV
Family and domain databases
InterPro	IPR004147. ABC_1. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABKA_DICDI

Accession

Primary (citable) accession number: Q54IH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 24, 2005
Last modified:	November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)