Reviewed, UniProtKB/Swiss-Prot Q54IF7 (VPS29_DICDI)

Names and origin

Protein names

Recommended name:
    Vacuolar protein sorting-associated protein 29
    EC=3.1.3.3

Gene names

Name:	vps29
ORF Names:	DDB_G0288787

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays a role in vesicular protein sorting By similarity. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport By similarity. The vps29-vps26-vps35 subcomplex may be involved in cargo selection By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Component of a retromer subcomplex consisting of vps29, vps26 and vps35 By similarity.
Subcellular location	Membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Endosome membrane; Peripheral membrane protein; Cytoplasmic side Potential.
Sequence similarities	Belongs to the VPS29 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endosome Membrane
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-KW internal side of plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Vacuolar protein sorting-associated protein 29		PRO_0000328097
Sites
	Metal binding	8	1	Zinc 1 By similarity
	Metal binding	10	1	Zinc 1 By similarity
	Metal binding	39	1	Zinc 1 By similarity
	Metal binding	39	1	Zinc 2 By similarity
	Metal binding	62	1	Zinc 2 By similarity
	Metal binding	86	1	Zinc 2 By similarity
	Metal binding	115	1	Zinc 2 By similarity
	Metal binding	117	1	Zinc 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54IF7-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: FB8A3619B45FCCE0	FASTA	183	20,414
	10 20 30 40 50 60 MFIIAIGDVH VPHRSYGIPP EFKKLLVPEK IQHILCTGNL VSKEIHDYFK VLTSDVHIVR 70 80 90 100 110 120 GDLDENTSYP DTKIVSIGQF KFGLCHGHQI VPWGDRASLA ALQRQLDVDV LISGHTHVLE 130 140 150 160 170 180 VFESNGKLFV NPGSATGAFS NISNDVIPSF VLMDVQSNNI TVYIYKLIDG QVKVEKIDHV KQQ

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000125 Genomic DNA. Translation: EAL63015.1.
RefSeq	XP_636520.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54IF7.
Genome annotation databases
GeneID	3388092.
GenomeReviews	Gene locus vps29 in contig CM000154_GR.
KEGG	ddi:DDB_0234192.
Organism-specific databases
dictyBase	DDB_G0288787. vps29.
Phylogenomic databases
OMA	KFEAYEH.
Enzyme and pathway databases
BRENDA	3.1.3.3. 424.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR000979. UPF0025. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
TIGRFAMs	TIGR00040. yfcE. 1 hit.
PROSITE	PS01269. UPF0025. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VPS29_DICDI

Accession

Primary (citable) accession number: Q54IF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)